Mitigative effects of zinc on cadmium-induced reproductive toxicity in the male freshwater crab Sinopotamon henanense

Liu, Jing; Wang, Ermeng; Jing, Weixin; Dahms‬, Hans-Uwe; Murugan, Kadarkarai; Wang, Lan

doi:10.1007/s11356-020-08074-y

Cited by 15 publications

(8 citation statements)

References 62 publications

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“…Another study found that 24 h of acute exposure to cadmium in Chinese mitten crabs ( Eriocheir japonica sinensis ) led to transcriptomic differences in the expression of genes relating to the immune and antioxidant defence functions of the crab [ 84 ]. These are not the only studies to investigate cadmium toxicity in crabs, as there is concern that cadmium may affect their reproductive capacity [ 85 ]. Likewise, a study in other crustaceans—crayfish ( Procambarus clarkii )—indicated that cadmium may alter their gut histology and the function of their gut microbiota [ 86 , 87 ].…”

Section: Cadmium Accumulation and Monitoring In Crabs And Crustaceansmentioning

confidence: 99%

Cadmium: A Focus on the Brown Crab (Cancer pagurus) Industry and Potential Human Health Risks

Lordan

Zabetakis

2022

Toxics

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Cadmium is a major health risk globally and is usually associated with pollution and anthropogenic activity. The presence of cadmium in food is monitored to ensure that the health and safety of consumers are maintained. Cadmium is ubiquitous in the Asian and Western diets, with the highest levels present in grains, leafy greens, and shellfish. As part of their natural lifecycle of moulting and shell renewal, all crustaceans—including the brown crab (Cancer pagurus)—bioaccumulate cadmium from their environment in their hepatopancreas. The brown crab is an important species to the crab-fishing industries of many European countries, including Ireland. However, the industry has come under scrutiny in Europe due to the presence of cadmium in the brown crab meat intended for live export to Asia. This review explores evidence regarding the effects of cadmium consumption on human health, with a focus on the brown crab. Differences in cadmium surveillance have given rise to issues in the crab industry, with economic consequences for multiple countries. Currently, evidence suggests that brown crab consumption is safe for humans in moderation, but individuals who consume diets characterised by high levels of cadmium from multiple food groups should be mindful of their dietary choices.

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Section: Cadmium Accumulation and Monitoring In Crabs And Crustaceansmentioning

confidence: 99%

Cadmium: A Focus on the Brown Crab (Cancer pagurus) Industry and Potential Human Health Risks

Lordan

Zabetakis

2022

Toxics

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“…Zn mitigating effects on Cd toxicity was also reported in male freshwater crab S . henenense (Liu et al, 2020). Although, the studies discussed so far buttress only the protective form of Zn metallic interaction excluding; the additive, synergistic and antagonistic forms.…”

Section: Introductionmentioning

confidence: 99%

Impacts of cadmium on male fertility: Lessons learnt so far

2022

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Cadmium (Cd) is one of the most dangerous heavy metals in the world. Globally, toxicities associated with cadmium and its attendant negative impact on humans and animals cannot be under-estimated. Cd is a heavy metal, and people are exposed to it through contaminated foods and smoking. Cd exerts its deleterious impacts on the testes (male reproductive system) by inducing oxidative stress, spermatogenic cells apoptosis, testicular inflammation, decreasing androgenic and sperm cell functions, disrupting ionic homeostasis, pathways and epigenetic gene regulation, damaging vascular endothelium and blood testes barrier. In association with other industrial byproducts, Cd has been incriminated for the recent decline of male fertility rate seen in both man and animals. Understanding the processes involved in Cd-induced testicular toxicity is vital for the innovation of techniques that will help ameliorate infertility in males. In this review, we summed up recent studies on the processes of testicular toxicity and male infertility due to Cd exposure. Also, the usage of different compounds including phytochemicals, and plant extracts to manage Cd reprotoxicity will be reviewed.

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“…Furthermore, they have been proven to dramatically improve the bioavailability and absorption of several medications ( Yuan et al, 2008 ; Refat et al, 2021 ; Isaac et al, 2017 ; Najafi et al, 2020 ). Several studies have used Zn or selenium to ameliorate oxidative damage and hormonal imbalance mediated by ABM ( Mansour et al, 2017 ) or cadmium ( Liu et al, 2020 ) in rats. These elements were utilized to mitigate pesticide-induced toxicity and oxidative stress in living organisms.…”

Section: Introductionmentioning

confidence: 99%

Ameliorating effect of the biological Zinc nanoparticles in abamectin induced hepato-renal injury in a rat model: Implication of oxidative stress, biochemical markers and COX-2 signaling pathways

et al. 2022

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Extensive use of abamectin (ABM) as an anthelmintic in veterinary systems adversely affects the health and welfare of animals and humans. Zinc nanoparticles (ZnNPs) have therapeutic benefits and ameliorate the effect of environmental pollutants. In this study, we assessed the ameliorative effect of ZnNPs against the sub-lethal toxicity of ABM in rats. Forty healthy rats were randomly selected into four groups (n = 10); the control received normal saline and test rats were treated orally twice weekly with ABM (1 mg/kg bwt), ZnNPs (10 mg/kg bwt) and ABM + ZnNPs for 28 days. Upon completion of the study period, blood and tissue samples were collected and prepared for hematological, biochemical, pathological, and immunohistochemical analysis. Our results showed that ABM treatment significantly decreased body weight gain (BWG), red blood cells (RBCs), hemoglobin (Hb), hematocrit (HC), and platelet (PLT); while it significantly increased white blood cells (WBCs) and lymphocytes. ABM also significantly decreased antioxidant enzyme activities: superoxide dismuthase (SOD), glutathione peroxidase (GPx), and catalase (CAT) and increased hydrogen peroxide and malondialdehyde levels compared with other groups. ABM significantly raised alanine aminotransferase (ALT), aspartate amino transaminase (AST), and alkaline phosphatase (ALP) levels, which was restored by co-administration of ZnNPs. Moreover, ZnNPs ameliorated ABM-mediated negative histopathological changes in the liver and kidney tissues, exhibiting a significant protective effect. Cyclooxygenase 2 (COX-2) + immuno-expression were reduced after pretreatment with ZnNPs. These findings suggested that co-administration of ZnNPs with ABM mitigated its toxicity by combating oxidative stress and boosting antioxidant capacity, indicating the efficacy of ZnNPs in attenuating ABM toxicity.

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Mitigative effects of zinc on cadmium-induced reproductive toxicity in the male freshwater crab Sinopotamon henanense

Cited by 15 publications

References 62 publications

Cadmium: A Focus on the Brown Crab (Cancer pagurus) Industry and Potential Human Health Risks

Cadmium: A Focus on the Brown Crab (Cancer pagurus) Industry and Potential Human Health Risks

Impacts of cadmium on male fertility: Lessons learnt so far

Ameliorating effect of the biological Zinc nanoparticles in abamectin induced hepato-renal injury in a rat model: Implication of oxidative stress, biochemical markers and COX-2 signaling pathways

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