Mitigation of streptozotocin‐induced alterations by natural agents via upregulation of
            <scp>PDX1</scp>
            and Ins1 genes in male rats

Shehata, Nagwa Ibrahim; Zeid, Seham Mohammed Abo; Aziz, Samy A. Abd El; Abdelgawad, Hanan Muhammad

doi:10.1111/jfbc.14086

Cited by 4 publications

(1 citation statement)

References 41 publications

(63 reference statements)

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“…Following pre-intervention of ALA, EPA and DHA, the expression levels of Ins1 and Ins2 were significantly ( p < 0.05) upregulated in comparison to those in the n-3 Def group. Shehata et al suggested that the upregulation of Ins genes could improve pancreatic function and ameliorate STZ-induced diabetes, which was in line with our findings [ 19 ]. These results suggested that pre-intervention of DHA could significantly improve pancreatic function and restore the structure of the pancreas among PUFA-treated groups.…”

Section: Resultssupporting

confidence: 92%

N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis

et al. 2023

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It has been reported that dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) exert therapeutic potential for the preservation of functional β-cell mass. However, the effect of dietary n-3 PUFA deficiency on pancreatic injury and whether the supplementation of n-3 PUFA could prevent the development of pancreatic injury are still not clear. In the present study, an n-3 PUFA deficiency mouse model was established by feeding them with n-3 PUFA deficiency diets for 30 days. Results showed that n-3 PUFA deficiency aggravated streptozotocin (STZ)-induced pancreas injury by reducing the insulin level by 18.21% and the HOMA β-cell indices by 31.13% and the area of islet by 52.58% compared with the STZ group. Moreover, pre-intervention with DHA and EPA for 15 days could alleviate STZ-induced pancreas damage by increasing the insulin level by 55.26% and 44.33%, the HOMA β-cell indices by 118.81% and 157.26% and reversed the area of islet by 196.75% and 205.57% compared to the n-3 Def group, and the effects were significant compared to γ-linolenic acid (GLA) and alpha-linolenic acid (ALA) treatment. The possible underlying mechanisms indicated that EPA and DHA significantly reduced the ration of n-6 PUFA to n-3 PUFA and then inhibited oxidative stress, inflammation and islet β-cell apoptosis levels in pancreas tissue. The results might provide insights into the prevention and alleviation of pancreas injury by dietary intervention with PUFAs and provide a theoretical basis for their application in functional foods.

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Section: Resultssupporting

confidence: 92%