Mitigating effects of antioxidant properties of black berry juice on sodium fluoride induced hepatotoxicity and oxidative stress in rats

Hassan, Hanaa A.; Yousef, Mokhtar I.

doi:10.1016/j.fct.2009.06.023

Cited by 107 publications

(62 citation statements)

References 30 publications

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“…Recently, the relationship between fluoride toxicity and elevated oxidative stress has been reported in rats, suggesting that oxidative/nitrosative damage is the major mode of action of fluoride (Hassan & Yousef, 2009). Fluoride at millimolar concentrations inhibits several enzymes both in vivo and in vitro (Mendoza-Schulz et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Increased ROS and lipid peroxidation (LP) productions have been implicated in the pathogenesis of toxic action of a wide range of compounds (Bencini et al, 2010). Epidemiological investigations indicated that long-term high-level fluoride intake can lead to severe damage in the metabolism of many systems and organs in animals and humans (Hassan & Yousef, 2009). Recent studies suggest that increased generation of ROS and enhanced LP have been shown to play an important role in fluorosis (Narayanaswamy & Piler, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of lycopene against fluoride toxicity in rats

Mansour

Tawfik

2011

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of lycopene against fluoride toxicity in rats

Mansour

Tawfik

2011

Pharmaceutical Biology

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“…Therefore, the present results revealed that BBJ has a protective effect against NaF-induced hepatotoxicity by antagonizing the free radicals generation and enhancement of the antioxidant defence mechanisms. (Hassan and Yousef, 2009). …”

Section: Mitigating Effects Of Antioxidant Properties Of Black Berry mentioning

confidence: 99%

Lipid Peroxidation End-Products as a Key of Oxidative Stress: Effect of Antioxidant on Their Production and Transfer of Free Radicals

El-Aal¹

2012

Lipid Peroxidation

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“…They found as well that black berry decreased the hepatotoxicity and oxidative stress of sodium fluoride (NaF) [6]. Hepatotoxicity of NaF elevated liver thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO), while reduced superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity and glutathione (GPX).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of White (Morus alba L.) and Black (Morus nigra L.)Berries against CCl4 Hepatotoxic Agent

Mnaa¹,

Aniess²,

Olwy³

et al. 2015

Adv Tech Biol Med

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Background and Aim: Our research investigates black, white and mixture of fresh berries role in liver injury caused by CCl 4 through biochemical parameters and histopathological determinations.Methods: Using berry as preventing or caring agents in comparing with treating or relieving or might curing agents against CCl 4 hepatotoxicity. Injection with CCl 4 was in the second 10 days, while preventing showed that feeding with berry on the first 10 days and relieving was feeding with berry on the third 10 days.Results: Preventing infected rats with white berry increased weight (17%), food efficiency ratio FER (6%), decreased aspartate aminotransferase (AST) (81%), urea (25.5%) comparing to infected rat group. Risk factor in lipid profile showed improvement by preventing black, white followed by mixture berries (26-58%) compared with CCl 4 group. Preventing with black, white then mixture berry showed significant improvement for risk factor. Generally, optimistic data has been found for preventing black berry in malondialdehyde (MDA) and fucosidase values in the final stage. In the first stage, preventing white and mixture fresh berry showed significant increase for antioxidant and fucosidase activity, respectively. Histopathological profiles indicated that relieving black berry and protected mixture were much enhanced than protected black and relieving mixture, respectively. Conclusion:Carbon tetrachloride is showing infection and hepatotoxicity in liver diseases due to its reactive intermediates. White, black and their equal mixture in the diet of Sprague-Dawley rats showed protective and even relieving for CCl 4 toxicity.

show abstract

Mitigating effects of antioxidant properties of black berry juice on sodium fluoride induced hepatotoxicity and oxidative stress in rats

Cited by 107 publications

References 30 publications

Efficacy of lycopene against fluoride toxicity in rats

Efficacy of lycopene against fluoride toxicity in rats

Lipid Peroxidation End-Products as a Key of Oxidative Stress: Effect of Antioxidant on Their Production and Transfer of Free Radicals

Antioxidant Activity of White (Morus alba L.) and Black (Morus nigra L.)Berries against CCl4 Hepatotoxic Agent

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