Misoprostol enhances early fracture healing: A preliminary biochemical study on rats

Milcan, Abtullah; Çolak, Mergül; Eskandari, Gülçin

doi:10.1016/j.bone.2007.07.003

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…Another study indicated that oral isotretinoin therapy inhibits bone turnover and calcium homeostasis ( 19 ). Elevation of the alkaline phosphatase level in serum was observed in misoprostol-treated rats ( 20 ). Ettinger ( 21 ) reported a marked increase in uric acid caused by methotrexate treatment.…”

Section: Discussionmentioning

confidence: 99%

Oral toxicity of isotretinoin, misoprostol, methotrexate, mifepristone and levonorgestrel as pregnancy category X medications in female mice

Kim

Shin²,

Yoo

et al. 2015

Experimental and Therapeutic Medicine

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An oral toxicity study of several pregnancy category X drugs was performed in female ICR mice. The drugs were administered orally once daily for 3 days at doses of 1, 10 and 100 μg/kg for isotretinoin; 6.7, 67 and 670 μg/kg for misoprostol; 83, 830 and 8,300 μg/kg for methotrexate; 3.3, 33 and 330 μg/kg for mifepristone; and 25, 250 and 2,500 μg/kg for levonorgestrel. During the test period, clinical signs, mortality, body weight, hematology, serum biochemistry and necropsy findings were examined. Following administration of methotrexate at 8,300 μg/kg, a number of animals exhibited decreased spontaneous activity, and one animal died. In the hematological analysis, compared with those treated with the control, the animals treated with the drugs exhibited similar significant decreases in the number of granulocytes and granulocyte differentiation, and increases in lymphocyte differentiation. In the serum biochemical analysis, animals receiving high doses of the five drugs demonstrated significant changes in uric acid, glucose, alkaline phosphatase, total bilirubin, lipase, total cholesterol and calcium. At necropsy, intestinal redness was frequently observed in animals that received the high dose of methotrexate. Uterus enlargement and ovary dropsy were also detected in the groups receiving mifepristone and levonorgestrel. Despite the short-term exposure, these drugs exhibited significant side effects, including white blood cell toxicity, in the mouse model. Category X drugs can be traded illegally via the internet for the purpose of early pregnancy termination. Thus, illegal abuse of the drugs should be further discouraged to protect mothers.

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Section: Discussionmentioning

confidence: 99%

Oral toxicity of isotretinoin, misoprostol, methotrexate, mifepristone and levonorgestrel as pregnancy category X medications in female mice

Kim

Shin²,

Yoo

et al. 2015

Experimental and Therapeutic Medicine

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“…In recent years, many biochemical factors like misoprostol, [9] melatonin, [10] strontium ranelate, [11] leptin [12] and mesenchymal stem cells [13] are shown to improve fracture healing. Low-intensity pulsed ultrasound, [14] electromagnetic and electric fields [15] have been also shown to accelerate fracture healing as mechanical factors.…”

Section: Discussionmentioning

confidence: 99%

Effect of extracorporeal shock wave therapy on fracture healing in rat femural fractures with intact and excised periosteum

Oktaş¹

2014

Eklem Hastalik Cerrahisi

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“…In experimental studies, misoprostol treatment was associated with an increase in bone turnover, with a net anabolic effect [6]. Osteo-inductive effects of misoprostol in the early bone healing period were defined [7]. Misoprostol has also been determined as an alternative treatment for osteopenia and osteoporosis in women during the postmenopausal period [8].…”

Section: Introductionmentioning

confidence: 99%

Anti-osteoporotic effects of melatonin and misoprostol in glucocorticoid-induced osteoporosis: An experimental study

Kutlu¹,

Üzüm²,

Durmuşcan³

et al. 2019

Journal of Surgery and Medicine

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Aim: Although there are some treatment options for glucocorticoid induced osteoporosis (GIO), new drug alternatives are still needed. In this study, we aimed to determine the protective effects of misoprostol and melatonin in an experimental GIO model. Methods: The rats were grouped into four, with 10 rats in each group. The 1st group was chosen as the control group, which were not intervened with. Group 2 was the steroid group, group 3 the misoprostol group and group 4, the melatonin group. To the rats in groups 2, 3 and 4, 10 mg/kg subcutaneous methylprednisolone was administered for 28 days. To the rats of the 3rd group, 200 mg/day misoprostol was given per day by a cannula to the stomach. The rats in the 4th group received 5mg/kg intraperitoneal melatonin during this 28-days period. Lumbar vertebrae and femur bone mineral density (BMD) of all rats were measured by Dual-energy X-ray absorptiometry (DEXA) and assessed in pre-and post-treatment periods. Results: In the steroid group, when the pre-and post-treatment-BMD values of the rats were compared, statistically significant decreases were found in vertebrae, whole femur, femur proximal, femur diaphysis and distal femur bone regions (P=0.011, P=0.005, P=0.007, P=0.005 and P=0.013; respectively). In the misoprostol group, a statistically significant decrease was observed only in the whole femur region (P=0.012) when the pre-and post-treatment BMD values of the rats were compared, while no significant changes were observed in vertebrae, femur proximal, femur diaphysis and distal femur bone regions (P=0.093, P=0.401, P=0.161 and P=0.123; respectively). In the melatonin group, when the pre-and post-treatment BMD values of the rats were compared, a statistically significant decrease was observed only in the vertebrae region (P=0.009), no significant changes were observed in whole femur, femur proximal, femur diaphysis and distal femur bone regions (P=0.386, P=0.445, P=1.000 and P=0.483; respectively). Conclusion: Positive effects of misoprostol and melatonin on bone metabolism were determined in this experimental study. Misoprostol and melatonin seem to be potential agents that can be used in the prevention of GIO.

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Misoprostol enhances early fracture healing: A preliminary biochemical study on rats

Cited by 4 publications

References 23 publications

Oral toxicity of isotretinoin, misoprostol, methotrexate, mifepristone and levonorgestrel as pregnancy category X medications in female mice

Oral toxicity of isotretinoin, misoprostol, methotrexate, mifepristone and levonorgestrel as pregnancy category X medications in female mice

Effect of extracorporeal shock wave therapy on fracture healing in rat femural fractures with intact and excised periosteum

Anti-osteoporotic effects of melatonin and misoprostol in glucocorticoid-induced osteoporosis: An experimental study

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