Effect of extracorporeal shock wave therapy on fracture healing in rat femural fractures with intact and excised periosteum

Oktaş, Birhan

doi:10.5606/ehc.2014.33

Cited by 18 publications

(16 citation statements)

References 21 publications

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“…On the other hand, the effects of gabapentin were assessed via radiographic, histological, and mechanical analysis of the fracture healing process. The standardized experimental fracture healing model applied in this study has been widely used in the literature [5–7, 29]. Standard drug administration was achieved by oral gavage twice a day by the same administrator at the same time every day of the study period.…”

Section: Discussionmentioning

confidence: 99%

Should orthopedic surgeons consider the effects of gabapentin administration on bone healing while treating a long bone fracture: experimental study in a rat model

Sofu

Koçkara

Aydın

et al. 2016

SICOT-J

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Objective: The main purpose of the present study was to assess the radiographic, histological, and mechanical effects of gabapentin on fracture healing in a rat model of femur fracture. Materials and methods: A standard transverse fracture of the mid-diaphysis was created. A total of 60 female Wistar-Albino rats with the mean age of 13.5 ± 1.2 weeks were used for this experimental trial. The rats were randomized into four groups with 15 animals included in each group. Group A and B were the control groups whereas C and D were the treatment groups. Drugs were delivered by oral gavage twice a day with the daily dosage calculated according to body surface area conversion to the human equivalent dosing regimen of 1200 mg/day. Radiographic, histological, and biomechanical evaluation was performed. Results: We could not detect any statistically significant difference between the control and gabapentin treatment groups according to the comparative assessment of radiographic scores on the 15th and 30th days. Although no significant differences were found between the groups on the 15th day, histological scores were better in the control group on the 30th day. According to the results of biomechanical testing, the fractured femurs resected from the control group exhibited significantly more strength on the 30th day. Conclusions: According to the data we acquired during the present study, administration of gabapentin negatively affects the fracture healing process especially in the aspects of histological progression as well as the biomechanical strength of the callus in a rat model.

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Section: Discussionmentioning

confidence: 99%

Should orthopedic surgeons consider the effects of gabapentin administration on bone healing while treating a long bone fracture: experimental study in a rat model

Sofu

Koçkara

Aydın

et al. 2016

SICOT-J

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show abstract

“…[1,9,14] The dosage of drug administration was calculated according to body surface area conversion recommended as the standard way to approximate equivalent exposure of drugs among different kinds of animals. [6] Additionally, administration of 1% methylcellulose (2 mL/day) by oral gavage in control group standardized the stress factor for all rats.…”

Section: Discussionmentioning

confidence: 99%

Pregabalin does not affect fracture healing adversely

Koçkara

Sofu

Issın

et al. 2017

Eklem Hastalik Cerrahisi

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“…[1][2][3][4][5] Because bone is highly vascularized, angiogenesis plays an extremely important role in bone formation during both bone development and fracture healing. [6,7] Previous studies have demonstrated that the angiogenic and osteogenic factors associated with the proteins of vascular endothelial growth factor (VEGF) and cysteine-rich 61 (CYR61) are involved in the process of fracture healing, [6][7][8][9] and that reduced vascularity at the fracture site is one of the most significant risk factors for delayed fracture healing. [3] Sildenafil and tadalafil are inhibitors of the enzyme phosphodiesterase-5 (PDE5).…”

mentioning

confidence: 99%

Positive effect of tadalafil, a phosphodiesterase-5 inhibitor, on fracture healing in rat femur

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Korkusuz

et al. 2015

Eklem Hastalik Cerrahisi

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Effect of extracorporeal shock wave therapy on fracture healing in rat femural fractures with intact and excised periosteum

Cited by 18 publications

References 21 publications

Should orthopedic surgeons consider the effects of gabapentin administration on bone healing while treating a long bone fracture: experimental study in a rat model

Should orthopedic surgeons consider the effects of gabapentin administration on bone healing while treating a long bone fracture: experimental study in a rat model

Pregabalin does not affect fracture healing adversely

Positive effect of tadalafil, a phosphodiesterase-5 inhibitor, on fracture healing in rat femur

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