Mismatch negativity (MMN) as a tool for investigating auditory discrimination and sensory memory in infants and children

Cheour, Marie; Leppänen, Paavo H.T.; Kraus, Nina

doi:10.1016/s1388-2457(99)00191-1

Cited by 246 publications

(162 citation statements)

References 102 publications

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“…1B, shaded regions). These selections captured the peak of the response in the group average data and conformed to the classic time ranges for MMR documented in the infant literature (25,29,30). The MMRs in the target windows were then averaged for each participant.…”

Section: Resultsmentioning

confidence: 99%

“…Differences have been documented between infants and adults in the MMR with later peak latency, smaller magnitude, and a shift in polarity for infants from a positive to a negative MMR with age and experience. The MMR has been considered fairly stable and readily observed across development (25,26). MEG technology, with its excellent temporal resolution (millisecond) and good spatial resolution for measuring neural activities (27), allows examination of the MMR at the cortical level.…”

Section: Significancementioning

confidence: 99%

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Musical intervention enhances infants’ neural processing of temporal structure in music and speech

Zhao

Kuhl

2016

Proc. Natl. Acad. Sci. U.S.A.

133

104

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Individuals with music training in early childhood show enhanced processing of musical sounds, an effect that generalizes to speech processing. However, the conclusions drawn from previous studies are limited due to the possible confounds of predisposition and other factors affecting musicians and nonmusicians. We used a randomized design to test the effects of a laboratory-controlled music intervention on young infants' neural processing of music and speech. Nine-month-old infants were randomly assigned to music (intervention) or play (control) activities for 12 sessions. The intervention targeted temporal structure learning using triple meter in music (e.g., waltz), which is difficult for infants, and it incorporated key characteristics of typical infant music classes to maximize learning (e.g., multimodal, social, and repetitive experiences). Controls had similar multimodal, social, repetitive play, but without music. Upon completion, infants' neural processing of temporal structure was tested in both music (tones in triple meter) and speech (foreign syllable structure). Infants' neural processing was quantified by the mismatch response (MMR) measured with a traditional oddball paradigm using magnetoencephalography (MEG). The intervention group exhibited significantly larger MMRs in response to music temporal structure violations in both auditory and prefrontal cortical regions. Identical results were obtained for temporal structure changes in speech. The intervention thus enhanced temporal structure processing not only in music, but also in speech, at 9 mo of age. We argue that the intervention enhanced infants' ability to extract temporal structure information and to predict future events in time, a skill affecting both music and speech processing.M usic training in early childhood has received increased attention as a model for the study of functional neural plasticity (1). Previous studies investigating musically trained adults and children have demonstrated their enhanced processing of musical pitch and meter in comparison with nontrained groups (2-6). Moreover, prior evidence also suggests generalization effects from early musical training to speech processing. For example, musically trained adults and children can better process pitch information in lexical tones and temporal information in syllable structure, compared with nonmusicians (7-10). These cross-domain effects from early music training to speech perception raise theoretically interesting and important questions about different levels of processing (e.g., lower level acoustic processing vs. higher level cognitive skills) affected by early experience (11).However, there are several methodological issues preventing strong causal inferences about the effects of early music training in studies comparing musicians with nonmusicians. First, predispositions (e.g., higher auditory acuity) may lead individuals to self-select early music training, thus contributing to the observed differences between musicians and nonmusicians. Second, there exists gre...

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Section: Resultsmentioning

confidence: 99%

Section: Significancementioning

confidence: 99%

Musical intervention enhances infants’ neural processing of temporal structure in music and speech

Zhao

Kuhl

2016

Proc. Natl. Acad. Sci. U.S.A.

133

104

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“…Some limitations of this work can be pointed out, such as the methodological diversity of the articles, regarding the parameters used to perform the MMN and presentation of the results found, regarding the values of latency and amplitude, and there is no standardization for population. There is no consensus to date on the best protocol to be used and normality patterns in the child population still need to be specified (6,13) , due to the fact that there are several parameters used to investigate and evaluate the Potential MMN, depending on the characteristics of the study population and estimated objectives.…”

Section: Discussionmentioning

confidence: 99%

“…Latency informs the course time of processing activity, while wave amplitude demonstrates the extent of neural allocation involved in the cognitive processes of potentials (10) . MMN is a procedure that has a good correlation with the results found in subjective evaluations that, similarly, analyzed the ability of auditory discrimination (6,13) . Its main advantage, compared to other exams, is that the wave appears independently of the attention of the individual to the presented sound stimuli (1,4,6,7,10,14) , that is, it can be registered without the influence of the attention of the subject and without requiring tasks, making it particularly suitable for clinical studies in evaluating the child population (4,11) .…”

Section: Introductionmentioning

confidence: 99%

“…Its main advantage, compared to other exams, is that the wave appears independently of the attention of the individual to the presented sound stimuli (1,4,6,7,10,14) , that is, it can be registered without the influence of the attention of the subject and without requiring tasks, making it particularly suitable for clinical studies in evaluating the child population (4,11) . Studies have shown that MMN can be a very useful evaluative means for recognizing changes in language (4,9) in children due to the possibility of assessing auditory processing deficit at an early age (9,13,15) Capable of analyzing neurophysiological plasticity (13) . However, nowadays, it is observed that other aspects can also be investigated through the realization of MMN in this population.…”

Section: Introductionmentioning

confidence: 99%

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Aplicabilidade do Mismatch Negativity na população infantil: revisão sistemática de literatura

Ferreira

Bueno

Costa

et al. 2017

Audiol., Commun. Res.

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Introduction: Mismatch Negativity (MMN) is an electrophysiological potential that evaluates the brain's capacity to discriminate sounds, regardless of attentional and behavioral capacity. Because it is an objective and user-friendly measure, it becomes promising in the study of auditory processing research in children. Purpose: To verify the applicability of Mismatch Negativity (MMN) in children. Research strategy: A search was conducted in August and September 2016 using the descriptors Evoked Potentials, Auditory AND Children, Eventrelated Potential AND Children and Electrophysiology AND Children in bibliographic collection of the electronic databases Portal BVS (Medline, IBECS and LILACS) and SciELO. Selection criteria: The selection of articles was carried out in Portuguese, English and Spanish published up to September 2016 without initial date limitation and whose approach to Mismatch Negativity was with the child population. Results: The search strategy resulted in the selection of 23 articles classified as original articles. The studies evidenced several applications of MMN in children, including autism spectrum disorder, auditory processing disorders, cleft lip and palate, prematurity, and language-specific disorder, being the majority of them in dyslexia. Conclusion: Despite the great variability involved in the measures of MMN, there is a wide clinical applicability of this electrophysiological potential in the infant population.

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Auditory Discrimination

Wildmo¹

2008

Encyclopedia of Special Education

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Mismatch negativity (MMN) as a tool for investigating auditory discrimination and sensory memory in infants and children

Cited by 246 publications

References 102 publications

Musical intervention enhances infants’ neural processing of temporal structure in music and speech

Musical intervention enhances infants’ neural processing of temporal structure in music and speech

Aplicabilidade do Mismatch Negativity na população infantil: revisão sistemática de literatura

Auditory Discrimination

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