Mismatch negativity is abnormal but not lateralizing in temporal lobe epilepsy

Zhao, Lili; An, Dongmei; Mao, Limei; Tang, Xiangdong; Zhou, Dong

doi:10.1016/j.yebeh.2016.11.007

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…The MMSE scale ranges from 0 to 30, with higher scores indicating better cognitive function. This task has also been used in previous studies of epilepsy . Social functioning was assessed using the socioeconomic status (SES) of the participants measured by the 5‐point Hollingshead–Redlich Scale, in which 1 = highest and 5 = lowest .…”

Section: Methodsmentioning

confidence: 99%

“…This task has also been used in previous studies of epilepsy. 30,31 Social functioning was assessed using the socioeconomic status (SES) of the participants measured by the 5-point Hollingshead-Redlich Scale, 32 in which 1 = highest and 5 = lowest. This scale was scored based on the occupational and educational levels that may be seriously affected in TLE.…”

Section: Participantsmentioning

confidence: 99%

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Altered upright face recognition and presence of face inversion effect in temporal lobe epilepsy: An event‐related potential study

Mogi

Tsunoda

Yoshino

2019

Psychiatry Clin Neurosci

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Aim Facial recognition can be assessed by examining an event‐related potential component, namely the N170. The amplitude of the N170 is larger in response to inverted faces than to upright faces. To examine facial processing in patients with temporal lobe epilepsy (TLE), we investigated the amplitude of the N170, the face inversion effect, and the association between social functioning and face‐specific configuration processing. Methods Sixteen patients with TLE and 17 normal controls (NC) participated in this study. Event‐related potentials in response to upright or inverted neutral faces and bicycles were recorded. Social functioning was assessed by the socioeconomic status of the participants using the 5‐point Hollingshead–Redlich Scale. Results Compared with NC, patients with TLE had decreased N170 amplitudes. The inversion effect was observed for face stimuli in both groups; however, no inversion effect was observed for bicycle stimuli. Additionally, in TLE patients, but not in NC, socioeconomic status was significantly correlated with the N170 amplitudes in response to upright faces. Conclusion In a social context, upright faces are processed as a whole. This process is impaired in TLE. Conversely, inverted faces are processed analytically. This function is normal in TLE. Abnormal face‐specific configuration processing may contribute to lower social functioning in TLE.

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Section: Methodsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Altered upright face recognition and presence of face inversion effect in temporal lobe epilepsy: An event‐related potential study

Mogi

Tsunoda

Yoshino

2019

Psychiatry Clin Neurosci

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“…The procedure of eliciting MMN is identical to our previous study [16]. The odd-ball paradigm was applied with brief pure tones as the stimuli.…”

Section: Methodsmentioning

confidence: 99%

Cognitive impairment in type 2 diabetes patients with and without diabetic peripheral neuropathy: a mismatch negativity study

Zhao¹,

Mao²,

Liu³

et al. 2021

NeuroReport

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ObjectivesTo assess the cognitive impairment in patients with type 2 diabetes mellitus (T2DM) using mismatch negativity (MMN) and to explore the relationship between cognitive impairment and diabetic peripheral neuropathy (DPN).Methods Sixty-six T2DM patients and 40 healthy controls were included. For each participant, mini-mental state examination (MMSE) was applied to assess the general cognitive function and MMN was elicited. T2DM patients were divided into two subgroups: subgroup DPN−, patients without DPN; subgroup DPN+, patients with DPN. The MMSE scores, MMN amplitudes and latencies were compared between the T2DM group and the control group using univariate analysis of variance procedures, and also among the controls, subgroup DPN− and subgroup DPN+. Pearson's correlation coefficients (r) were used to analyze potential confounding clinical factors associated with MMN. Results T2DM patients had significantly lower MMSE scores compared with controls (23.25 ± 2.86 vs. 27.15 ± 1.83; P < 0.01), whereas those of the two subgroups were not significantly different. Both subgroup DPN+ and DPN− had longer latencies and lower amplitudes of MMN than the controls. The latencies of MMN were significantly longer in subgroup DPN+ compared with subgroup DPN−. The latency of MMN was positively correlated with the duration of the disease. Conclusion Cognitive decline exists in patients with T2DM irrespective of the presence of DPN. Patients with DPN may have more severe cognitive dysfunction than those without DPN. MMN may be a promising tool for evaluating cognitive function.

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Mismatch negativity is abnormal but not lateralizing in temporal lobe epilepsy

Cited by 5 publications

References 35 publications

Altered upright face recognition and presence of face inversion effect in temporal lobe epilepsy: An event‐related potential study

Altered upright face recognition and presence of face inversion effect in temporal lobe epilepsy: An event‐related potential study

Cognitive impairment in type 2 diabetes patients with and without diabetic peripheral neuropathy: a mismatch negativity study

Neural correlates of novelty detection in the primary auditory cortex of behaving monkeys

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