Neural correlates of novelty detection in the primary auditory cortex of behaving monkeys

Gong, Yumei; Song, Peirun; Du, Xinyu; Zhai, Yuying; Xu, Haoxuan; Ye, Hangting; Bao, Xuehui; Huang, Qianyue; Tu, Zhiyi; Chen, Pei; Zhao, Xuan; Pérez-González, David; Malmierca, Manuel S.; Yu, Xiongjie

doi:10.1016/j.celrep.2024.113864

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2024

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Cited by 3 publications

References 87 publications

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Protocol for behavioral and neural recording in macaques during a novelty detection task

Du,

Song,

Gong

et al. 2024

STAR Protocols

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Protocol for behavioral and neural recording in macaques during a novelty detection task

Du,

Song,

Gong

et al. 2024

STAR Protocols

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A new function of offset response in the primate auditory cortex: marker of temporal integration

Song,

Xu,

et al. 2024

Commun Biol

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Beyond Auditory Relay: Dissecting the Inferior Colliculus’s Role in Sensory Prediction, Reward Prediction and Cognitive Decision-Making

Du,

Xu,

Song

et al. 2024

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The Inferior Colliculus (IC) has traditionally been regarded as an important relay in the auditory pathway, primarily involved in relaying auditory information from the brainstem to the thalamus. However, this study uncovers the multifaceted role of the IC in bridging auditory processing, sensory prediction, and reward prediction. Through extracellular recordings in monkeys engaged in a sound duration-based novelty detection task, we observed a "climbing effect" in neuronal firing rates, indicative of an enhanced response over sound sequences linked to sensory prediction rather than reward anticipation. Further exploration revealed a direct correlation between IC neuronal activity and behavioral choices, suggesting its involvement in decision-making processes. Additionally, our findings demonstrate reward prediction errors within the IC, highlighting its complex integration in auditory and reward processing. This research challenges conventional views of the IC, showcasing its integral role in cognitive and sensory processing and emphasizing its importance in integrated brain functions.

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Neural correlates of novelty detection in the primary auditory cortex of behaving monkeys

Cited by 3 publications

References 87 publications

Protocol for behavioral and neural recording in macaques during a novelty detection task

Protocol for behavioral and neural recording in macaques during a novelty detection task

A new function of offset response in the primate auditory cortex: marker of temporal integration

Beyond Auditory Relay: Dissecting the Inferior Colliculus’s Role in Sensory Prediction, Reward Prediction and Cognitive Decision-Making

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