Mismatch negativity in treatment-resistant depression and borderline personality disorder

He, Wei; Chai, Herzl; Zheng, Leilei; Yu, Wenjun; Chen, Wanzhen; Li, Jianming; Chen, Wei; Wang, Wei

doi:10.1016/j.pnpbp.2009.12.021

Cited by 32 publications

(44 citation statements)

References 62 publications

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“…Lepistö 23,24 MMN was elicited by using high stimulus intensities (60 dB over the individual threshold, 23 or 80 dB 24 ). We will consider separately these 2 aspects of MMN behavior (reduced latency and increased amplitude) in depressed patients, because they could have different causes.…”

Section: Discussionmentioning

confidence: 99%

Abnormality of Auditory Mismatch Negativity in Depression and Its Dependence on Stimulus Intensity

et al. 2015

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Mismatch negativity (MMN) is thought to reveal several abnormalities of cognitive functioning. Although depression often affects cognitive functioning, previous studies concerning MMN in depressed patients provided conflicting results. In recent reports, it has been suggested that depressed patients may show abnormal auditory response to regular auditory stimuli presented with at a relatively high intensity. We thus recorded acoustic MMN in 16 drug-free patients suffering from moderate depression and in 10 healthy subjects at 2 different stimulus intensities. Differences in MMN latency and amplitude between depressed patients and healthy subjects reached the significance level only for high intensity stimulation, and they were consistent with a dysfunction of frontal MMN subcomponents in depressed patients. This finding suggests that consistent MMN abnormalities can be observed in depressed patients by using high-intensity stimulation; moreover, it supports the hypothesis of disturbances of frontal networks in depression even in early stages of disease.

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Section: Discussionmentioning

confidence: 99%

Abnormality of Auditory Mismatch Negativity in Depression and Its Dependence on Stimulus Intensity

et al. 2015

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“…For example, Kahkonen and colleagues [30] examined the auditory modality and proposed that the MMN amplitude in response to 10% frequency deviance was increased in patients with MDD. He et al [31] also reported enhanced frequency-MMN amplitudes in treatment-resistant depressed individuals compared with healthy volunteers. In contrast, a recent study conducted by Qiao et al [32] found that patients with MDD exhibited decreased duration-MMN amplitudes over the frontal–central area under the increment condition (150 ms MMN), although no significant difference between patients and healthy controls was found for temporal MMN regardless of whether the increment or decrement (50 ms MMN) condition was used.…”

Section: Introductionmentioning

confidence: 92%

Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder

Pang

Chang

et al. 2014

PLoS ONE

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BackgroundMajor depressive disorder (MDD) is an important and highly prevalent mental disorder characterized by anhedonia and a lack of interest in everyday activities. Additionally, patients with MDD appear to have deficits in various cognitive abilities. Although a number of studies investigating the central auditory processing of low-level sound features in patients with MDD have demonstrated that this population exhibits impairments in automatic processing, the influence of emotional voice processing has yet to be addressed. To explore the automatic processing of emotional prosodies in patients with MDD, we analyzed the ability to detect automatic changes using event-related potentials (ERPs).MethodThis study included 18 patients with MDD and 22 age- and sex-matched healthy controls. Subjects were instructed to watch a silent movie but to ignore the afferent acoustic emotional prosodies presented to both ears while continuous electroencephalographic activity was synchronously recorded. Prosodies included meaningless syllables, such as “dada” spoken with happy, angry, sad, or neutral tones. The mean amplitudes of the ERPs elicited by emotional stimuli and the peak latency of the emotional differential waveforms were analyzed.ResultsThe sad MMN was absent in patients with MDD, whereas the happy and angry MMN components were similar across groups. The abnormal sad emotional MMN component was not significantly correlated with the HRSD-17 and HAMA scores, respectively.ConclusionThe data indicate that patients with MDD are impaired in their ability to automatically process sad prosody, whereas their ability to process happy and angry prosodies remains normal. The dysfunctional sad emotion-related MMN in patients with MDD were not correlated with depression symptoms. The blunted MMN of sad prosodies could be considered a trait of MDD.

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“…Abnormal brain electrophysiological recordings have been suggested to result from dysfunctional neurotransmitters and could be a neurophysiological marker of TRD (He, et al, 2010a). Mismatch negativity, an early component of cortical event-related potentials (ERPs), is recorded during an oddball task (the presence of an odd stimulus amongst a sequence of stimuli)…”

Section: Neurophysiological Activitymentioning

confidence: 99%

“…and may indicate information processing impairments (He, et al, 2010a). Generated in the supratemporal area and frontal lobe, mismatch negativity is mediated by neurotransmitters associated with depression, such as dopamine, serotonin, glutamate and GABA (He, et al, 2010a).…”

Section: Neurophysiological Activitymentioning

confidence: 99%

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Chronic and treatment-resistant depression

Murphy¹

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Major Depression does not always remit even with appropriate treatment, and unremitting or difficult-to-treat depression is thought to contribute to the large disease burden caused by depression. Difficult-to-treat depression is an overarching term that can be used to describe depression which is chronic, unremitting or treatment-resistant. The concept of difficult-to-treat depression and the terms used to describe it have not been well validated or universally adopted for use in research and clinical practice. Accordingly, the overarching aim of this thesis was to investigate difficult-to-treat depression, including its conceptualisation and its correlates, with a particular focus on chronic and treatment-resistant depression (TRD). Three methodological approaches were employed to examine this complex phenomenon: 1) a systematic review of the literature; 2) analysis of epidemiological data; and 3) analysis of clinical data. found to have a lifetime prevalence of 4.6% (95% CI: 3.9 -5.3%) and was found to be present in 29.4% (95% CI: 25.6 -33.3%) of community-residing individuals with a lifetime depressive disorder. Higher rates of psychiatric co-morbidity (OR = 1.42; 95% CI = 1.26-1.61), older current age (OR = 1.04; 95% CI = 1.02-1.05), a younger age of onset (OR = .97; 95% CI = .95-.98) and more frequent episodes of depression (OR = 1.75; 95% CI = 1.07-2.86) were significant correlates of chronic depression. Differences in health service utilisation associated with chronic depression were assessed to determine whether chronic depression treated in the tertiary care sector was likely to represent TRD. Survey respondents with chronic depression who were treated in tertiary care settings had more complex presentations and many of the clinical features previously associated with TRD, including higher levels of medical and psychiatric co-morbidity, greater traumatic load, higher levels of disability, greater symptom severity and greater risk of attempting suicide. iv The findings from the NSMHWB suggested that those whose chronic depression is treated in tertiary care settings may be less responsive to treatment, thus indicating likely TRD. In order to assess the degree of TRD in patients seen in tertiary care settings a sample of depressed inpatients (N = 70) was recruited. The majority of these depressed inpatients had a chronic illness trajectory (N = 64; 91.4%) and had a moderate to high level of TRD as determined by the five existing staging models of TRD. Each of the five staging models of TRD was highly correlated with the other four models, suggesting a substantial degree of agreement between models on their ratings of TRD. An omnibus measure of TRD (M = 0; SD = 4.5) was created by combining the five TRD models into one composite index. Using this composite index as the outcome variable, the following covariates were found to be associated with higher levels of TRD: higher prevalence of suicide attempts (β = 1.71, t(11) = 3.62, p < .001), older current age (β = 14, t(11) = 2.92, p < .005), earlier a...

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Mismatch negativity in treatment-resistant depression and borderline personality disorder

Cited by 32 publications

References 62 publications

Abnormality of Auditory Mismatch Negativity in Depression and Its Dependence on Stimulus Intensity

Abnormality of Auditory Mismatch Negativity in Depression and Its Dependence on Stimulus Intensity

Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder

Chronic and treatment-resistant depression

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