Misdiagnosed desmoplastic small round cell tumor of the pleura: Case report and literature review

Zhang, Jian; Huang, Shaohong; Zhong, Wen‐Zhao; Lijia, Gu

doi:10.1016/j.jfma.2011.12.002

Cited by 8 publications

(12 citation statements)

References 5 publications

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“…The immunohistochemical results of the present study were mainly consistent with previous observations. However, the present case of DRSCT was negative for epithelial cell markers and fewer mitotic figures were identified, compared with that of previous reports (2,3,8,9). It was hypothesized that these two factors may be associated with the relatively good prognosis of the patient in the present case.…”

Section: Discussioncontrasting

confidence: 56%

“…A number of radiological findings in pleural DSRCT have previously been described (2,3,8,9); however, contrast-enhanced CT findings have not been well addressed. According to the literature on pleural DSRCT, radiological manifestations are variable (2,3,8,9).…”

Section: Discussionmentioning

confidence: 99%

“…According to the literature on pleural DSRCT, radiological manifestations are variable (2,3,8,9). Jian et al (9) and Parkash et al (2) reported diffuse irregular or nodular pleural thickening, as well as pleural effusion of pleural DSRCT on plain CT in adolescents and young adults. Oliveira et al (8) identified a solid mass in the superior mediastinum, multiple pulmonary nodules and a voluminous right pleural effusion, with involvement of the liver and spleen.…”

Section: Discussionmentioning

confidence: 99%

“…Review of the English literature revealed that, to date, <15 cases of primary DSRCT in the pleura (including the present case) have been reported worldwide (PubMed, http://www.ncbi.nlm.nih.gov/pubmed/) (1)(2)(3)(4)(5)(6)(7)(8)(9). Among these cases, there are few computed tomography (CT) findings of pleural DSRCT, which have been previously described in detail (2,3,8,9). The present study describes a rare case of pleural DSRCT with differential contrast CT findings in a 72-year-old female, and reviews the English literature.…”

Section: Introductionmentioning

confidence: 94%

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Desmoplastic small round cell tumor: A case report of a rare differential diagnosis of solid tumors of the pleura

et al. 2015

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Abstract. Desmoplastic small round cell tumor (DSRCT) presents as a rare separate clinical pathological entity, and pleural DSRCT is very rare. Following review of the English literatures it was revealed that, to date, <15 cases of primary DSRCT of the pleura have been reported worldwide. Among these, there are few computed tomography (CT) findings of pleural DSRCT which have previously been described in detail. The present study reports a pathologically proven case of pleural DSRCT, with varying contrast CT findings in a 72-year-old female, which appeared as a large (12.0x10.0x6.5 cm), smooth, oval mass in the left lower thorax with slight-moderate uniform enhancement on contrast-enhanced CT. To the best of our knowledge, the present report is the first to describe the large solid-tumor pattern and the patient is the eldest reported case of pleural DSRCT.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Desmoplastic small round cell tumor: A case report of a rare differential diagnosis of solid tumors of the pleura

et al. 2015

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“…Although most of the reported cases were confirmed by a surgical biopsy under general anesthesia, the procedure is considered to be invasive due to the need for general anesthesia. A previous report demonstrated the successful diagnosis of a case using LAT (13). LAT is being increasingly adopted for the investigation of suspected benign and malignant pleural diseases.…”

Section: Discussionmentioning

confidence: 96%

Desmoplastic Small Round Cell Tumor of the Pleura Successfully Treated with a Lower Dose of Pazopanib

et al. 2016

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Desmoplastic small round cell tumor (DSRCT) is an aggressive mesenchymal tumor which primarily affects the abdomen. Even a multimodal approach rarely achieves durable remission and the optimal therapy for extended disease is unknown. We herein describe a rare case of DSRCT arising from the pleura in a 32-year-old man. Initial therapy, which included chemotherapy, surgery and radiotherapy, achieved a partial response for only two months. Although salvage chemotherapies had no effect, pazopanib treatment shrank the tumors and was well-tolerated on an outpatient basis. From the viewpoint of quality of life, pazopanib may therefore be a good therapeutic option for this aggressive disease.

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Desmoplastic small round cell tumors of the pleura: a review of the clinical literature

Fois

Pirina

Arcadu

et al. 2017

Multidiscip Respir Med

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Desmoplastic small round cell tumor of the pleura is a rare malignancy, with only a few cases reported in the scientific literature. The aim of the present review is to discuss the demographic, pathological, clinical, and therapeutic features of this rare tumor. English-language articles published since 1989, when the first case of desmoplastic small round cell tumor of the pleura was described, were retrieved, and fifteen cases included in fourteen articles were revised. The mean age of the patients was 25.5 years, out of them 60% were males. Chest pain, pleural effusion, and dyspnea were the most common clinical manifestations, while chest roentgenogram and computed tomography were the imaging techniques most commonly used. Surgical biopsy was employed in 80% of the cases for diagnosis. A multidisciplinary approach consisting in a combination of surgery with chemotherapy and radiation therapy was adopted in most cases. Only two patients (13.3%) were alive at 3 years from diagnosis, reflecting the aggressiveness of the disease, and the poor outcomes of the treatments currently available. Desmoplastic small round cell tumors of the pleura are extremely aggressive and challenging to diagnose, because of their rarity and unspecific demographic, clinical, and radiological features. An in-depth knowledge of such features is necessary for the optimal management of patients with this rare malignancy.

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Misdiagnosed desmoplastic small round cell tumor of the pleura: Case report and literature review

Cited by 8 publications

References 5 publications

Desmoplastic small round cell tumor: A case report of a rare differential diagnosis of solid tumors of the pleura

Desmoplastic small round cell tumor: A case report of a rare differential diagnosis of solid tumors of the pleura

Desmoplastic Small Round Cell Tumor of the Pleura Successfully Treated with a Lower Dose of Pazopanib

Desmoplastic small round cell tumors of the pleura: a review of the clinical literature

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