Miscellaneous meroterpenoids from Ganoderma applanatum

Two rare meroterpenoidal rotamers from Ganoderma applanatum

“…We have characterized several meroterpenoids as a new class of metabolites from Ganoderma. [3][4][5][6][7][8][9][10] Biological evaluation revealed their potential on oxidative stress, 2,3 inammation, 2 and T-type calcium channels. 7 To further explore the chemical and biological diversity of meroterpenoids in Ganoderma, the title fungal species was studied and structurally novel meroterpenoids were described by us.…”

Meroterpenoids from Ganoderma Species: A Review of Last Five Years

“…Compound 3 was isolated from G. lucidum and displayed weak renoprotective effect [ 31 ]. The biological assay of applanatumols S and T ( 5 , 6 ) from G. applanatum [ 32 ], and ganoleucin B ( 8 ) from G. leucocontextum didn’t show inhibitory activities against COX-1, COX-2, HMG-CoA reductase and α -glucosidase, respectively [ 33 ]. However, ganomycin J ( 9 ) from G. lucidum showed strong inhibitory activity against HMG-CoA reductase with an IC 50 value of 30.3 μM [ 34 ].…”

THE TRITERPENOID AND STEROID FROM THE FRUITING BODY OF Ganoderma applanatum (Pers.) Pat. IN VIETNAM

“…Ganoderma applanatum (Ganodermataceae) that has been widely used as a folk medicine for the treatment and prevention of various diseases [13]. Herein, we report the isolation of five compounds (ergosterol (1), 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (2); ergosta-7,22-dien-3β-ol (3); lanosta-7,9(11),24-triene-3,26-diol (4) and 3β-hydroxy-5α-lanosta-7,9,24(E)-trien-26-oic acid (5)) from fruiting body of Ganoderma applanatum (Pers.)…”

“…(Ganodermataceae). The structures of these compounds were elucidated using a combination of 1D and 2D NMR techniques ( 1 H-, 13 C-NMR, HSQC and HMBC).…”