Mis-splicing yields circular RNA molecules.

Cocquerelle, Claude; Mascrez, Bénédicte; Hétuin, Dominique; Bailleul, Bernard

doi:10.1096/fasebj.7.1.7678559

Cited by 1,004 publications

(747 citation statements)

References 17 publications

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“…Both Group I introns (found in eukaryotes and bacteria) and bulge-helixbulge-derived introns (found in archaea) can be circularized after excision from precursor tRNA and rRNA (18,21,22,35,36). In addition, in rare cases aberrant mRNA processing in eukaryotes can generate circular mRNA fragments (37)(38)(39)(40). The previously described circular RNAs are not known to function directly in cellular processes, making the possibility that circular box C͞D RNAs guide RNA modification in archaea even more provocative.…”

Section: Resultsmentioning

confidence: 99%

Circular box C/D RNAs in Pyrococcus furiosus

Starostina

Marshburn

Johnson

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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In eukaryotes, box C͞D modification guide RNAs are made by two primary pathways (2, 5, 10, 11). Some are found in the introns of host genes, and the linear box C͞D RNAs are processed from debranched lariats. In other cases, linear box C͞D RNAs are processed from mono-or polycistronic transcripts synthesized from independent promoters. Box C͞D RNAs were found only recently in archaea (12, 13). The pathway by which archaeal box C͞D RNAs are made is unknown. The archaeal box C͞D RNAs are located primarily in intergenic regions of the genome, sometimes overlapping the 3Ј or 5Ј end of flanking ORFs (1, 4, 12, 13). Independent promoters have not been identified.In the course of analyzing a cDNA library of small RNAs from P. furiosus, we observed an interesting incongruence between the linear sequence of some box C͞D RNA clones

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Section: Resultsmentioning

confidence: 99%

Circular box C/D RNAs in Pyrococcus furiosus

Starostina

Marshburn

Johnson

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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“…Only a small number of circRNAs in different organisms have been identified, and they were generally disregarded as the results of mis-splicing and as by-products of pre-mRNA processing. [3][4][5][6] However, recent advances using biochemical enrichment strategies and novel bioinformatics approaches coupled with deep sequencing have allowed comprehensive investigation of circRNAs. [7][8][9][10] Specifically, a large number of circRNAs have been successfully identified in various cell lines and across different species.…”

Section: Introductionmentioning

confidence: 99%

The emerging role and clinical implication of human exonic circular RNA

Lyu

Huang

2016

RNA Biology

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Circular RNA from backspliced exons (or exonic circular RNA, circRNA) is a type of covalently closed noncolinear RNA that was recently rediscovered in eukaryotes. Although circRNAs are often expressed at low levels, emerging evidence indicates that many circRNAs are linked to physiological development and various diseases. Notably, circRNAs have been shown to serve as oncogenic stimuli or tumor suppressors in cancer. circRNAs may regulate gene expression through different mechanisms. In addition, circRNAs have been shown to be useful as biomarkers of diseases due to their stability, specific expression and relation to diseases both in cells and in extracellular fluid. This review summarizes current knowledge of human circRNAs and discusses the emerging role and clinical implication of these multifarious transcripts.

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“…1 Additional studies reported further new examples of circRNAs over the years, [2][3][4][5][6][7][8][9] yet the extent of the prevalence of the circularization phenomenon was not clear, as the available examples remained limited. The advent of high-throughput sequencing revealed that circRNAs are a large class of abundant RNAs with complex developmental-and cellspecific expression patterns.…”

Section: Introductionmentioning

confidence: 99%

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

et al. 2016

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Circular RNAs (circRNAs) constitute a large class of RNA species formed by the back-splicing of co-linear exons, often within protein-coding transcripts. Despite much progress in the field, it remains elusive whether the majority of circRNAs are merely aberrant splicing by-products with unknown functions, or their production is spatially and temporally regulated to carry out specific biological functions. To date, the majority of circRNAs have been cataloged in resting cells. Here, we identify an LPS-inducible circRNA: mcircRasGEF1B, which is predominantly localized in cytoplasm, shows cell-type specific expression, and has a human homolog with similar properties, hcircRasGEF1B. We show that knockdown of the expression of mcircRasGEF1B reduces LPS-induced ICAM-1 expression. Additionally, we demonstrate that mcircRasGEF1B regulates the stability of mature ICAM-1 mRNAs. These findings expand the inventory of functionally characterized circRNAs with a novel RNA species that may play a critical role in fine-tuning immune responses and protecting cells against microbial infection.

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Mis-splicing yields circular RNA molecules.

Cited by 1,004 publications

References 17 publications

Circular box C/D RNAs in Pyrococcus furiosus

Circular box C/D RNAs in Pyrococcus furiosus

The emerging role and clinical implication of human exonic circular RNA

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

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