The emerging role and clinical implication of human exonic circular RNA

Lyu, Dongbin; Huang, Shenglin

doi:10.1080/15476286.2016.1227904

Cited by 94 publications

(69 citation statements)

References 58 publications

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“…Functions of circRNAs remain largely unclear. CircRNAs may be generated from exonic or intronic sequence and function as modifiers of parental gene expression . In the current study, we sequenced four circRNAs of interest following a microarray screening.…”

Section: Discussionmentioning

confidence: 99%

Dysregulated circRNAs in plasma from active tuberculosis patients

Gao

et al. 2018

J Cellular Molecular Medi

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Endogenous circular RNAs (circRNAs) have been reported in various diseases. However, their role in active TB remains unknown. The study was aimed to determine plasma circRNA expression profile to characterize potential biomarker and improve our understanding of active TB pathogenesis. CircRNA expression profiles were screened by circRNA microarrays in active TB plasma samples. Dysregulated circRNAs were then verified by qRT‐PCR. CircRNA targets were predicted based on analysis of circRNA‐miRNA‐mRNA interaction. GO and KEGG pathway analyses were used to predict the function of circRNA. ROC curve was calculated to evaluate diagnostic value for active TB. A total of 75 circRNAs were significantly dysregulated in active TB plasma. By further validation, hsa_circRNA_103571 exhibited significant decrease in active TB patients and showed potential interaction with active TB‐related miRNAs such as miR‐29a and miR‐16. Bioinformatics analysis revealed that hsa_circRNA_103571 was primarily involved in ras signalling pathway, regulation of actin cytoskeleton, T‐ and B‐cell receptor signalling pathway. ROC curve analysis suggested that hsa_circRNA_103571 had significant value for active TB diagnosis. Circulating circRNA dysregulation may play a role in active TB pathogenesis. Hsa_circRNA_103571 may be served as a potential biomarker for active TB diagnosis, and hsa_circRNA_103571‐miRNA‐mRNA interaction may provide some novel mechanism for active TB.

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Section: Discussionmentioning

confidence: 99%

Dysregulated circRNAs in plasma from active tuberculosis patients

Gao

et al. 2018

J Cellular Molecular Medi

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“…However, the peculiarities of circular RNAs (circRNAs), an enigmatic member of the RNA family, are not well characterized. CircRNAs were first observed nearly 40 years ago, but are recently recognized as regulatory molecules that are pervasive in the cytoplasm of eukaryocytes [13]. Initially, circRNAs were mistakenly interpreted as a fraction of splicing errors or functionless transcriptional byproducts during pre-mRNA splicing [14].…”

Section: Introductionmentioning

confidence: 99%

Profiles and Bioinformatics Analysis of Differentially Expressed Circrnas in Taxol-Resistant Non-Small Cell Lung Cancer Cells

Chen

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: Circular RNAs (circRNAs) act as microRNA (miRNA) sponges that regulate gene expression and are involved in physiological and pathological processes. In this study, we evaluated the roles of circRNAs in the chemoresistance of non-small cell lung cancer (NSCLC) to taxol. Methods: High-throughput circRNA microarrays were employed to investigate the circRNA profiles of parental A549 and taxol-resistant A549/Taxol cells. We predicted the miRNA targets of differentially expressed circRNAs via miRNA prediction software and then constructed a circRNA/miRNA network using Cytoscape. Bioinformatics analyses were performed to annotate dysregulated circRNAs in detail. Results: We detected 2909 significantly upregulated and 8372 downregulated circRNAs in A549/Taxol cells compared with A549 cells. The circRNA/miRNA network displayed their interactions, suggesting that circRNAs exert biological effects by absorbing and sequestering miRNA molecules. Computational Gene Ontology and pathway analyses were used to determine the biological function and signaling pathways of host genes of dysregulated circRNAs and to identify potential molecular mechanisms prompting the resistance of NSCLC to taxol. Conclusion: This study focusing on circRNAs related to taxol resistance provides a basis for clarifying the development and progression of drug resistance and for identifying therapeutic targets in NSCLC.

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“…circRNAs are single‐stranded covalently closed transcripts. Microarray or RNA sequencing analysis showed that circRNAs are widely dysregulated in cancers and potentially play suppressive or oncogenic roles in multiple cancers . circRNAs could be enriched and stable in exosomes.…”

Section: Oncogenic Roles Of Exosomes In Cancermentioning

confidence: 99%

“…Microarray or RNA sequencing analysis showed that cir-cRNAs are widely dysregulated in cancers and potentially play suppressive or oncogenic roles in multiple cancers. 112 circRNAs could be enriched and stable in exosomes. Exosomes containing tumor-specific circRNAs are released by tumor cells.…”

Section: Exosomal Mirnas Circrnas and Lncrnas In Cancersmentioning

confidence: 99%

Exosomes and cancer: From oncogenic roles to therapeutic applications

et al. 2019

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Exosomes belong to extracellular vehicles that were produced and secreted from most eukaryotic cells and are involved in cell‐to‐cell communications. They are an effective delivery system for biological compounds such as mRNAs, microRNAs (miRNAs), proteins, lipids, saccharides, and other physiological compounds to target cells. In this way, they could influence on cellular pathways and mediate their physiological behaviors including cell proliferation, tumorigenesis, differentiation, and so on. Many research studies focused on their role in cancers and also on potentially therapeutic and biomarker applications. In the current study, we reviewed the exosomes' effects on cancer progression based on their cargoes including miRNAs, long noncoding RNAs, circular RNAs, DNAs, mRNAs, proteins, and lipids. Moreover, their therapeutic roles in cancer were considered. In this regard, we have given a brief overview of challenges and obstacles in using exosomes as therapeutic agents.

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The emerging role and clinical implication of human exonic circular RNA

Cited by 94 publications

References 58 publications

Dysregulated circRNAs in plasma from active tuberculosis patients

Dysregulated circRNAs in plasma from active tuberculosis patients

Profiles and Bioinformatics Analysis of Differentially Expressed Circrnas in Taxol-Resistant Non-Small Cell Lung Cancer Cells

Exosomes and cancer: From oncogenic roles to therapeutic applications

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