Mirror therapy for improving motor function after stroke

Thieme, Holm; Morkisch, Nadine; Mehrholz, Jan; Pohl, Marcus; Behrens, Johann; Borgetto, Bernhard; Dohle, Christian

doi:10.1002/14651858.cd008449.pub3

Cited by 270 publications

(264 citation statements)

References 131 publications

Supporting

Mentioning

194

Contrasting

Unclassified

Order By: Relevance

“…Weakened parietal-to-M1 interactions (Grefkes and Fink, 2011, Takeuchi et al, 2012) have been previously identified in stroke, and restoring functional interactions among this network has been positively correlated with good recovery (Carter et al, 2010, van Meer et al, 2010, Wang et al, 2010, Grefkes and Fink, 2011, Rehme et al, 2011, Rehme et al, 2012, van Meer et al, 2012, De Vico Fallani et al, 2016). Mirror feedback, therefore, may be a useful clinical tool, as it has been shown to improve some outcomes in moderately to severely impaired patients (Thieme et al, 2012, Thieme et al, 2013, Pollock et al, 2014), and to activate specific networks that may favor recovery, particularly in patients who cannot otherwise engage their paretic hand in exercise. It remains unknown if similar networks could be activated in acutely impaired stroke patients; this is a focus of ongoing investigations in our lab.…”

Section: Discussionmentioning

confidence: 99%

“…These data, therefore, provide a neural basis for virtual mirror feedback, by showing that mirror feedback can activate ipsilesional motor-related hubs that are important for the recovery process. The findings about the neural underpinnings of mirror feedback are encouraging particularly in light of recent clinical studies showing that MVF may show promise in restoring function after stroke (Yavuzer et al, 2008, Dohle et al, 2009, Thieme et al, 2012, Thieme et al, 2013). The goal of this project is to fill this gap by identifying the neural network and mechanisms by which the ipsilesional motor cortex is facilitated by MVF.…”

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

Network interactions underlying mirror feedback in stroke: A dynamic causal modeling study

Saleh

Yarossi

Manuweera

et al. 2017

NeuroImage: Clinical

View full text Add to dashboard Cite

Mirror visual feedback (MVF) is potentially a powerful tool to facilitate recovery of disordered movement and stimulate activation of under-active brain areas due to stroke. The neural mechanisms underlying MVF have therefore been a focus of recent inquiry. Although it is known that sensorimotor areas can be activated via mirror feedback, the network interactions driving this effect remain unknown. The aim of the current study was to fill this gap by using dynamic causal modeling to test the interactions between regions in the frontal and parietal lobes that may be important for modulating the activation of the ipsilesional motor cortex during mirror visual feedback of unaffected hand movement in stroke patients. Our intent was to distinguish between two theoretical neural mechanisms that might mediate ipsilateral activation in response to mirror-feedback: transfer of information between bilateral motor cortices versus recruitment of regions comprising an action observation network which in turn modulate the motor cortex. In an event-related fMRI design, fourteen chronic stroke subjects performed goal-directed finger flexion movements with their unaffected hand while observing real-time visual feedback of the corresponding (veridical) or opposite (mirror) hand in virtual reality. Among 30 plausible network models that were tested, the winning model revealed significant mirror feedback-based modulation of the ipsilesional motor cortex arising from the contralesional parietal cortex, in a region along the rostral extent of the intraparietal sulcus. No winning model was identified for the veridical feedback condition. We discuss our findings in the context of supporting the latter hypothesis, that mirror feedback-based activation of motor cortex may be attributed to engagement of a contralateral (contralesional) action observation network. These findings may have important implications for identifying putative cortical areas, which may be targeted with non-invasive brain stimulation as a means of potentiating the effects of mirror training.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

Network interactions underlying mirror feedback in stroke: A dynamic causal modeling study

Saleh

Yarossi

Manuweera

et al. 2017

NeuroImage: Clinical

View full text Add to dashboard Cite

show abstract

“…This experiment is " based on Mirror therapy based non-invasive treatment of chronic stroke patients [56]. subject's forearm in the intended direction {t right } or {t lef t } (repeated every 2 s).…”

Section: !'mentioning

confidence: 99%

“…This nding $ emerged as the central element in rehabilitation of stroke patients to regain their motor functions. movement therapy [24] and mirror-based therapies [56]. They can be divided in three categories such as human assisted therapy [15], robotics ' assisted therapy [31] and the emerging Brain-Computer Interface (BCI) assisted robot therapies [34] [ 43][51].…”

mentioning

confidence: 99%

Design and evaluation of action observation and motor imagery based BCIs using Near-Infrared Spectroscopy

Abibullaev

Lee

et al. 2017

Measurement

View full text Add to dashboard Cite

“…It is proposed that MT acts to restore the correspondence between motor output (commands sent to the affected limb) and sensory input (visual feedback of the affected limb moving as commanded) [11], and thus enhances recovery of motor control in the affected limb. Motor outcomes associated with upper limb MT include motor recovery as measured by the Brunnstrom stages and Fugl-Meyer [15, 16, 17], and improved speed and accuracy of movement [10] (see Thieme et al [18], Rothgangel et al [19] and Ezendam et al [20] for reviews).…”

Section: Introductionmentioning

confidence: 99%

A novel bilateral lower extremity mirror therapy intervention for individuals with stroke

Crosby

Marrocco

Brown

et al. 2016

Heliyon

View full text Add to dashboard Cite

Despite improvements made in stroke rehabilitation, motor impairment and gait deficits persist at discharge. New interventions are needed. Mirror therapy has promise as one element of a rehabilitation program. The primary objectives were to 1) describe a bilateral, lower extremity mirror therapy (LE-MT) device and training protocol and 2) investigate the feasibility of LE-MT. A LE-MT device was constructed to train bilateral LE movements for 30 min, 3 times/week for 4 weeks, as an adjunct to physiotherapy in three individuals post-stroke. Sessions were digitally recorded and reviewed to extract feasibility measures; repetitions, rests and session duration. Pre and post measures of gait and motor impairment were taken. Two participants completed 100% of the sessions and a third completed 83% due to a recurrence of pre-existing back pain. Repetitions increased and session duration was maintained. Number of rests decreased for two participants and increased for one participant. Participants reported fatigue and mild muscle soreness but also that the intervention was tolerable. Positive gait changes included increased velocity and decreased variability. LE motor impairment also improved. A bilateral LE-MT adjunct intervention for stroke is feasible and may have positive effects. A history of low back pain should be a precaution.

show abstract

Mirror therapy for improving motor function after stroke

Cited by 270 publications

References 131 publications

Network interactions underlying mirror feedback in stroke: A dynamic causal modeling study

Network interactions underlying mirror feedback in stroke: A dynamic causal modeling study

Design and evaluation of action observation and motor imagery based BCIs using Near-Infrared Spectroscopy

A novel bilateral lower extremity mirror therapy intervention for individuals with stroke

Contact Info

Product

Resources

About