MiRNAs profile as biomarkers of nutritional therapy for the prevention of type 2 diabetes mellitus: From the CORDIOPREV study

Jiménez-Lucena, Rosa; Alcalá‐Díaz, Juan F.; Roncero-Ramos, Irene; López-Moreno, Javier; Camargo, Antonio; Gómez-Delgado, Francisco; Quintana-Navarro, Gracia M.; Vals-Delgado, Cristina; Rodríguez-Cantalejo, Fernando; Luque, Raúl M.; Delgado-Lista, Javier; Ordovás, José M.; Pérez‐Martínez, Pablo; Rangel‐Zúñiga, Oriol A.

doi:10.1016/j.clnu.2020.06.035

Cited by 25 publications

(22 citation statements)

References 53 publications

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“…[3] Whereas these new biomarkers have improved the assessment of the T2D risk, they do not inform on how to reduce the risk, although a miRNAs profile has recently been shown to partially determine the risk associated with the consumption of a specific diet. [23] Dietary factors are of paramount importance in the management and prevention of T2D; however, there is no consensus about the best dietary pattern, given the different effects observed in the management of T2D by different authors, which suggests that population-specific factors may determine the success in preventing T2D of a given nutritional therapy. [5] Recent studies have suggested that gut microbiome composition may play a role the different responses to dietary interventions observed.…”

Section: Discussionmentioning

confidence: 99%

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A Diet‐Dependent Microbiota Profile Associated with Incident Type 2 Diabetes: From the CORDIOPREV Study

Camargo

Vals-Delgado

Alcalá‐Díaz

et al. 2020

Molecular Nutrition Food Res

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Scope: The differences between the baseline gut microbiota of patients who developed type 2 diabetes (T2D) consuming a low-fat (LF) or a Mediterranean (Med) diet are explored and risk scores are developed to predict the individual risk of developing T2D associated with the consumption of LF or Med diet. Methods and Results: All the patients from the CORDIOPREV study without T2D at baseline (n = 462) whose fecal sample are available, are included. Gut microbiota is analyzed by 16S sequencing and the risk of T2D after a median follow-up of 60 months assessed by Cox analysis. Linear discriminant analysis effect size (LEfSe) analysis shows a different baseline gut microbiota in patients who developed T2D consuming LF and Med diets. A higher abundance of Paraprevotella, and lower Gammaproteobacteria and B. uniformis are associated with T2D risk when an LF diet is consumed. In contrast, higher abundances of Saccharibacteria, Betaproteobacteria, and Prevotella are associated with T2D risk when a Med diet is consumed. Conclusion: The results suggest that different interactions between the microbiome and dietary patterns may partially determine the risk of T2D development, which may be used for selecting personalized dietary models to prevent T2D.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Diet‐Dependent Microbiota Profile Associated with Incident Type 2 Diabetes: From the CORDIOPREV Study

Camargo

Vals-Delgado

Alcalá‐Díaz

et al. 2020

Molecular Nutrition Food Res

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“…In addition to the abovementioned examples, the recent results showed that circulating miRNA may be utilized to select a personalized diet model to prevent the development of DM2. In the case of patients with cardiovascular diseases, initial high miR-150 along with low miR-29a, miR-28-3p, and miR-126 in subjects on a Mediterranean diet, and low initial level of miR-145 in subjects on low-fat high-complex carbohydrate diet, was associated with a higher risk of development DM2 (Jimenez-Lucena et al 2021). Therefore, the profile of circulating miRNAs may be also used to select a group of patients for a particular treatment in DM2 (Formichi et al 2021) and nutritional therapy to lower the risk of disease development (Jimenez-Lucena et al 2021).…”

Section: Circulating Mirna As Potential Biomarkers For Dm2mentioning

confidence: 97%

Circulating miRNA as potential biomarkers for diabetes mellitus type 2: should we focus on searching for sex differences?

et al. 2022

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microRNAs are non-coding molecules, approximately 22 nucleotides in length, that regulate various cellular processes. A growing body of evidence has suggested that their dysregulated expression is involved in the pathogenesis of diverse diseases, including diabetes mellitus type 2 (DM2). Early onset of this chronic and complex metabolic disorder is frequently undiagnosed, leading to the development of severe diabetic complications. Notably, DM2 prevalence is rising globally and an increasing number of articles demonstrate that DM2 susceptibility, development, and progression differ between males and females. Therefore, this paper discusses the role of microRNAs as a source of novel diagnostic biomarkers for DM2 and aims to underline the importance of sex disparity in biomarkers research. Taking into account an urgent need for the development of sex-specific diagnostic strategies in DM2, recent results have shown that circulating miRNAs are promising candidates for sex-biased biomarkers.

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“…An interesting recent article highlighted that circulating levels of specific miRNAs could predict the most successful dietary model for preventing the development of type 2 diabetes mellitus in coronary heart disease patients. In detail, low baseline plasma levels of miR-145 were associated with a higher risk of developing type 2 diabetes mellitus in those subjects consuming a low-fat high-complex carbohydrate diet ( Jimenez-Lucena et al, 2020 ). Polyphenols of extra-virgin olive oil may control in vitro adipocytes inflammation through the modulation of miR-155, let-7c and miR-34a ( Carpi et al, 2019 ; Scoditti et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Intake of Natural Compounds and Circulating microRNA Expression Levels: Their Relationship Investigated in Healthy Subjects With Different Dietary Habits

et al. 2021

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Diet has a strong influence on many physiological processes, which in turn have important implications on a variety of pathological conditions. In this respect, microRNAs (miRNAs), a class of small non-coding RNAs playing a relevant epigenetic role in controlling gene expression, may represent mediators between the dietary intake and the healthy status. Despite great advances in the field of nutri-epigenomics, it remains unclear how miRNA expression is modulated by the diet and, specifically, the intake of specific nutrients. We investigated the whole circulating miRNome by small RNA-sequencing performed on plasma samples of 120 healthy volunteers with different dietary habits (vegans, vegetarians, and omnivores). Dietary intakes of specific nutrients were estimated for each subject from the information reported in the food-frequency questionnaire previously validated in the EPIC study. We focused hereby on the intake of 23 natural compounds (NCs) of the classes of lipids, micro-elements, and vitamins. We identified 78 significant correlations (rho > 0.300, p-value < 0.05) among the estimated daily intake of 13 NCs and the expression levels of 58 plasma miRNAs. Overall, vitamin D, sodium, and vitamin E correlated with the largest number of miRNAs. All the identified correlations were consistent among the three dietary groups and 22 of them were confirmed as significant (p-value < 0.05) by age-, gender-, and body-mass index-adjusted Generalized Linear regression Model analysis. miR-23a-3p expression levels were related with different NCs including a significant positive correlation with sodium (rho = 0.377) and significant negative correlations with lipid-related NCs and vitamin E. Conversely, the estimated intake of vitamin D was negatively correlated with the expression of the highest number of circulating miRNAs, particularly miR-1277-5p (rho = −0.393) and miR-144-3p (rho = −0.393). Functional analysis of the targets of sodium intake-correlated miRNAs highlighted terms related to cardiac development. A similar approach on targets of those miRNAs correlated with vitamin D intake showed an enrichment in genes involved in hormone metabolisms, while the response to chronic inflammation was among the top enriched processes involving targets of miRNAs negatively related with vitamin E intake. Our findings show that nutrients through the habitual diet influence circulating miRNA profiles and highlight that this aspect must be considered in the nutri-epigenomic research.

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MiRNAs profile as biomarkers of nutritional therapy for the prevention of type 2 diabetes mellitus: From the CORDIOPREV study

Cited by 25 publications

References 53 publications

A Diet‐Dependent Microbiota Profile Associated with Incident Type 2 Diabetes: From the CORDIOPREV Study

A Diet‐Dependent Microbiota Profile Associated with Incident Type 2 Diabetes: From the CORDIOPREV Study

Circulating miRNA as potential biomarkers for diabetes mellitus type 2: should we focus on searching for sex differences?

Intake of Natural Compounds and Circulating microRNA Expression Levels: Their Relationship Investigated in Healthy Subjects With Different Dietary Habits

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