MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapies

Panda, Mamta; Kalita, Elora; Singh, Satyendra; Kumar, Ketan; Rao, Abhishek; Prajapati, Vijay Kumar

doi:10.1016/j.lfs.2022.120761

Cited by 31 publications

(21 citation statements)

References 207 publications

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“…Some research aims to inhibit 5”UTR function by noncoding RNAs. For instance, Baldassarre et al described the potential use of noncoding RNAs and innovative therapeutic strategies to target the 5”UTR of SARS-CoV-2 [ 14 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2

Yang

Wang

et al. 2022

Virulence

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Section: Discussionmentioning

confidence: 99%

Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2

Yang

Wang

et al. 2022

Virulence

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“…The eukaryotic transcription regulators would be the most important targets of 18 SARS-CoV-2-derived mature miRNAs; these targets are all involved in transcription process [ 69 ]. Mostly viral miRNAs have shown their role in overall pathogenesis by regulating host genes [ 125 ]. The findings of an in silico study have shown an analogy between the SARS CoV2 genome and regulatory host miRNA such as miR8066, miR5197, miR3611, miR3934-3p, miR1307-3p, miR3691-3p, and miR1468-5p [ 59 ].…”

Section: Ability Of Sars-cov-2 Escaping the Host Immune System Throug...mentioning

confidence: 99%

“…Along the same line, miR-146a, miR-21, and miR-142 were found in COVID-19 patients triggering the inflammatory machinery through activating MAPK and NF-Ƙb signaling [ 140 ]. It was identified that restricting miR-21 or miR-142 would promote multiple cascading reactions and activation of the JAK-STAT cell signaling circuit, resulting in proinflammatory status advancements [ 125 ]. Trobaugh and Klimstra [ 46 ] suggested that viral protein-mediated changes in miRNA expression may occur through an indirect mechanism governed by viral inhibition of the innate immune response rather than a direct interaction between the viral protein and the transcription factors that regulate miRNA expression.…”

Section: Ability Of Sars-cov-2 Escaping the Host Immune System Throug...mentioning

confidence: 99%

miRNAs: The Key Regulator of COVID-19 Disease

Hardin

Xiao

2022

International Journal of Cell Biology

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As many parts of the world continue to fight the innumerable waves of COVID-19 infection, SARS-CoV-2 continues to sculpt its antigenic determinants to enhance its virulence and evolvability. Several vaccines were developed and used around the world, and oral antiviral medications are being developed against SARS-CoV-2. However, studies showed that the virus is mutating in line with the antibody’s neutralization escape; thus, new therapeutic alternatives are solicited. We hereby review the key role that miRNAs can play as epigenetic mediators of the cross-talk between SARS-CoV-2 and the host cells. The limitations resulting from the “virus intelligence” to escape and antagonize the host miRNAs as well as the possible mechanisms that could be used in the viral evasion strategies are discussed. Lastly, we suggest new therapeutic approaches based on viral miRNAs.

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“…In SARS-CoV-2 infection, expression of more than 70 miRNAs were deregulated in peripheral blood [ 161 ], suggesting the importance of these noncoding RNAs in the infectious process. They have also been proposed as potential biomarkers of the severity of COVID-19 [ 162 , 163 ], as well as for therapeutic approaches to SARS-CoV-2 infection [ 164 , 165 ].…”

Section: The Landscape Of Nucleic Acid-based Therapies In Sars-cov-2mentioning

confidence: 99%

Transcriptomics and RNA-Based Therapeutics as Potential Approaches to Manage SARS-CoV-2 Infection

Arriaga-Canon

Contreras-Espinosa

Rebollar-Vega

et al. 2022

IJMS

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SARS-CoV-2 is a coronavirus family member that appeared in China in December 2019 and caused the disease called COVID-19, which was declared a pandemic in 2020 by the World Health Organization. In recent months, great efforts have been made in the field of basic and clinical research to understand the biology and infection processes of SARS-CoV-2. In particular, transcriptome analysis has contributed to generating new knowledge of the viral sequences and intracellular signaling pathways that regulate the infection and pathogenesis of SARS-CoV-2, generating new information about its biology. Furthermore, transcriptomics approaches including spatial transcriptomics, single-cell transcriptomics and direct RNA sequencing have been used for clinical applications in monitoring, detection, diagnosis, and treatment to generate new clinical predictive models for SARS-CoV-2. Consequently, RNA-based therapeutics and their relationship with SARS-CoV-2 have emerged as promising strategies to battle the SARS-CoV-2 pandemic with the assistance of novel approaches such as CRISPR-CAS, ASOs, and siRNA systems. Lastly, we discuss the importance of precision public health in the management of patients infected with SARS-CoV-2 and establish that the fusion of transcriptomics, RNA-based therapeutics, and precision public health will allow a linkage for developing health systems that facilitate the acquisition of relevant clinical strategies for rapid decision making to assist in the management and treatment of the SARS-CoV-2-infected population to combat this global public health problem.

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MiRNA-SARS-CoV-2 dialogue and prospective anti-COVID-19 therapies

Cited by 31 publications

References 207 publications

Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2

Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2

miRNAs: The Key Regulator of COVID-19 Disease

Transcriptomics and RNA-Based Therapeutics as Potential Approaches to Manage SARS-CoV-2 Infection

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