miRNA-24 and miRNA-466i-5p controls inflammation in rat hepatocytes

Saravanan, S.; Thirugnanasambantham, Krishnaraj; Hanieh, Hamza; Karikalan, Kulandaivelu; Sekar, Durairaj; Rajagopalan, Rukkumani; Ibrahim, Hairul-Islam Mohamed

doi:10.1038/cmi.2014.67

Cited by 20 publications

(11 citation statements)

References 10 publications

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“…microRNAs (miRNAs) are short non-coding RNA molecules consisting of 21-25 nucleotides (nt) in length. miRNAs silence their cognate target genes by inhibiting mRNA translation or degrading the mRNA molecules by binding to their 3 -untranslated (UTR) region [4][5][6]. This step plays a vital role in the regulation of mRNA expression.…”

Section: Introductionmentioning

confidence: 99%

Significance of microRNA 21 in gastric cancer

Sekar

Ravindran

Thirugnanasambantham

et al. 2016

Clinics and Research in Hepatology and Gastroenterology

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Section: Introductionmentioning

confidence: 99%

Significance of microRNA 21 in gastric cancer

Sekar

Ravindran

Thirugnanasambantham

et al. 2016

Clinics and Research in Hepatology and Gastroenterology

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“…Of the group of miRNAs lacking human counterparts but most significantly up-regulated in DMM cartilage, miR-6931-5p and miR-3082-5p have not been associated with OA previously and their roles are not well known. miR-466i-5p on the other hand has been suggested to have a role in controlling inflammation, through targeting the expression of inflammatory markers such as Cox-2/Ptgs2 and iNOS in liver inflammation (57). The roles of these miRNAs specifically in OA also remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Cartilage microRNA dysregulation in mouse osteoarthritis overlaps with patient disease candidates

Kung

Ravi

Rowley

et al. 2017

Preprint

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The regulatory interplay between the joint cartilage and subchondral bone (SCB) is known be important in osteoarthritis (OA) pathology. Thus, to explore the role of microRNAs in osteoarthritis, we conducted global microRNA microarray expression profiling on microdissected medial tibial cartilage and SCB in a mouse model of OA produced by medial meniscus destabilization (DMM). Compared to sham-operated mice, DMM-operated mice had characteristic cartilage degeneration, SCB sclerosis and osteophyte formation. miRNA expression profiling revealed no statistically significant dysregulation of SCB miRNAs between DMM and sham-operated mice. In contrast, 139 miRNAs were found to be differentially expressed in DMM cartilage at 1 or 6 weeks post-surgery. To prioritize OAcandidates, dysregulated miRNAs were filtered against miRNAs identified in human OA and then using paired miRNA:mRNA expression analysis we identified a cohort of down-regulated microRNAs 26b, 30c, 98, 149, 210, 342, 140, with corresponding changes in predicted target transcripts. Comparisons with microRNA dysregulation in DMM mouse cartilage where aggrecan cleavage was genetically ablated demonstrated that all, except Let-7e, were independent of aggrecan breakdown, earmarking this cohort of microRNAs of relevance to the critical early stages of OA initiation.

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“…In mammals, miRNAs are generally considered to be negative regulators of gene expression, acting either through translational repression of target mRNAs or by decreasing mRNA stability (18). However, in select cases, miRNAs are also involved in the upregulation of certain mRNAs (19, 20). Currently, upwards of 1800–2000 known human miRNAs have been identified, and it is estimated that miRNAs regulate ~60% of protein-coding genes (21).…”

Section: Differentially Expressed Mirnas In Type 1 Diabetesmentioning

confidence: 99%

Nucleic acid biomarkers of β cell stress and death in type 1 diabetes

Syed

Evans‐Molina²

2016

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of the review The purpose of this review is to summarize recent advances in the development of nucleic acid-based biomarkers in type 1 diabetes (T1D). Recent findings Recent rodent and human studies have identified new roles for stress pathways intrinsic to the β cell during the development of T1D. As such, methods to identify an authentic nucleic acid signature of β cell stress and/or death may improve our ability to predict T1D at earlier timepoints, allowing for optimal timing of immunomodulatory interventions. To this end, both targeted and unbiased approaches have begun to identify changes in microRNA expression patterns in T1D. Moreover, a number of groups have developed distinct assays that quantitatively detect circulating unmethylated insulin DNA, which is thought to primarily emanate from dying β cells. Summary Here we highlight unique blood and urine miRNA signatures identified in T1D cohorts, compare differences between first, second, and third generation assays that detect circulating unmethylated insulin DNA, and review recent technological advances that have the capacity to improve T1D biomarker development.

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miRNA-24 and miRNA-466i-5p controls inflammation in rat hepatocytes

Cited by 20 publications

References 10 publications

Significance of microRNA 21 in gastric cancer

Significance of microRNA 21 in gastric cancer

Cartilage microRNA dysregulation in mouse osteoarthritis overlaps with patient disease candidates

Nucleic acid biomarkers of β cell stress and death in type 1 diabetes

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