Abstract:The regulatory interplay between the joint cartilage and subchondral bone (SCB) is known be important in osteoarthritis (OA) pathology. Thus, to explore the role of microRNAs in osteoarthritis, we conducted global microRNA microarray expression profiling on microdissected medial tibial cartilage and SCB in a mouse model of OA produced by medial meniscus destabilization (DMM). Compared to sham-operated mice, DMM-operated mice had characteristic cartilage degeneration, SCB sclerosis and osteophyte formation. miR… Show more
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