miRNA-197 and miRNA-184 are associated with brain metastasis in EGFR-mutant lung cancers

Remón, Jordi; Álvarez-Berdugo, Daniel; Majem, Margarita; Morán, Teresa; Reguart, Noemı́; Lianes, P.

doi:10.1007/s12094-015-1347-2

Cited by 25 publications

(19 citation statements)

References 50 publications

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“…Furthermore, several tumor suppressor genes such as CTNNAI, IKZFI, or EBF3 (Bennett et al, 2008;Ye et al, 2009;Javierre et al, 2011), might become novel targets of miR-197 during EMT induction, of which much work is warranted. Recently, in a retrospective study, J. Remon et al suggested that high-miR-197 might predict the risk of brain metastases information in EGFR-mutant-NSCLC (Remon et al, 2015) and EGFR mutational status represented a better overall survival in NSCLC with brain metastasis (Eichler et al, 2010). As for, the direct nexus of miR-197 and EGFR remains elucidated.…”

Section: Mir-197 In Invasion and Metastasismentioning

confidence: 99%

“…Thus, it was of great concern to investigate the roles and potential mechanisms of key miRNAs in tumorigenic driver pathways. Among them, miR-197, transcribed from the genomic region of chromosome 1p13.3, was found to be significantly dysregulated in a wide range of diseases, such as lung cancer (Remon et al, 2015), breast cancer (Shaker et al, 2015), ovarian cancer (Zou et al, 2015), hepatocellular carcinoma (HCC) , colorectal cancer , thyroid cancer (Weber et al, 2006), head and neck carcinoma (Dai et al, 2011), prostate cancer , follicular thyroid carcinoma (FTC) (Weber et al, 2006), non-alcoholic fatty liver disease (Celikbilek et al, 2014), primary biliary cirrhosis (Ninomiya et al, 2013). Furthermore, increasing evidences had confirmed that miR-197 played a vital role in cell proliferation, apoptosis, differentiation, metastasis and drug resistance, as well as other cellular processes through interacting with particular RNA species (Huang et al, 2014) (Table 1).…”

Section: Introductionmentioning

confidence: 99%

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miR-197: A novel biomarker for cancers

Wang

Chen

et al. 2016

Gene

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Section: Mir-197 In Invasion and Metastasismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

miR-197: A novel biomarker for cancers

Wang

Chen

et al. 2016

Gene

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“…Multivariate Cox proportional hazard regression analysis of each parameter suggested that high miR-423-5p expression resulted in significantly adverse prognostic factors that were independent of BM. The altered expression of a series of NSCLC-associated miRNAs was identified in previous studies (e.g., miR-675-5p, miR-200, and miR-1253) 22 – 25 . However, miRNAs associated with the risk of developing BM in NSCLC have not been extensively researched.…”

Section: Discussionmentioning

confidence: 54%

MiR-423-5p in brain metastasis: potential role in diagnostics and molecular biology

Sun

Ding

et al. 2018

Cell Death Dis

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During the last several years, a growing number of studies have shown that microRNAs (miRNAs) participate in cancer metastasis. Brain metastasis (BM) is a frequent complication of lung adenocarcinoma (LAD), and the incidence of locally advanced LAD with BM can be as high as 30–50%. This study was performed to identify the miRNA expression patterns of LAD with BM and to determine the biological role that miRNAs play in tumorigenesis. To this end, we conducted microarray and quantitative PCR analyses to evaluate BM-related miRNAs independently validated from a total of 155 patients with LAD. A series of in vivo and in vitro assays were also conducted to verify the impact of miRNAs on BM. We found significantly increased expression of miR-423-5p, and BM was predicted in non-small cell lung cancer when compared to LAD without BM. We next examined the function of miR-423-5p and discovered that it significantly promoted colony formation, cell motility, migration, and invasion in vitro. We computationally and experimentally confirmed that metastasis suppressor 1 (MTSS1) was a direct miR-423-5p target. Through a combination of image, histological, and molecular analyses, we found that miR-423-5p overexpression significantly increased tumor burden, local invasion, and distant BM. The level of MTSS1 expression was inversely correlated with miR-423-5p upregulation in the LAD specimens and was associated with survival of patients with BM. MiR-423-5p promoted BM in LAD and inhibited MTSS1 expression. Together, these results show that MiR-423-5p has the potential to be a marker of BM and/or a therapeutic target in LAD.

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“…The results of the experiments of remon et al revealed three microrNas involved in Nsclc brain metastasis. These are mir-197, mir-184 and mir-423-5p over-expressed in Nsclc Bm+ patients compared to a control group of Nsclc Bm-patients 33 . mirNa-197 overexpression is a potential biomarker for early detection of lung cancers and also correlates with metastasis 34 .…”

Section: The Role Of Mirnas In Brain Metastasismentioning

confidence: 87%

The role of microRNA in metastatic processes of non-small cell lung carcinoma

Pastorkova¹,

Škarda²,

Andel³

2016

BIOMED PAP

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Background. MicroRNAs are small non-coding one-stranded RNA molecules that play an important role in the posttranscriptional regulation of genes. Bioinformatic predictions indicate that each miRNA can regulate hundreds of target genes. MicroRNA expression can be associated with various cellular processes leading to the metastasis of malignant tumours including non-small cell lung carcinoma. This review summarizes current knowledge on the role of microRNAs in NSCLC metastasis to the brain and lymph nodes. Methods. A search of the NCBI/PubMed database for publications on expression levels and the mechanisms of microRNA action in NSCLC metastasis. Results and Conclusion. Dysregulation of microRNAs in NSCLC can be associated with brain and lymph node metastasis. There are differences in microRNA expression profiling between NSCLC with and without metastases but it is currently not possible to reliably predict the site of metastasis in NSCLC. Based on data from RNAmicroarrays, bioinformatics analysis is able to predict the target genes of highlighted microRNAs, providing us with complex information about cancer cell features such as enhanced proliferation, migration and invasion. Such microRNAs may then be knocked-down using siRNAs or substituted with miRNA mimics. RNA microarray profiling may thus be a useful tool to select up-or down-regulated microRNAs. A number of authors suggest that microRNAs could serve as biomarkers and therapeutic targets in the treatment of NSCLC metastasis.

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miRNA-197 and miRNA-184 are associated with brain metastasis in EGFR-mutant lung cancers

Abstract: miRNA-197 and miRNA-184 are overexpressed in EGFR-mutant patients with BM and they might be a new biomarker for stratifying the risk of BM in this subpopulation.

Cited by 25 publications

References 50 publications

miR-197: A novel biomarker for cancers

miR-197: A novel biomarker for cancers

MiR-423-5p in brain metastasis: potential role in diagnostics and molecular biology

The role of microRNA in metastatic processes of non-small cell lung carcinoma

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