2016
DOI: 10.5507/bp.2016.021
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Abstract: Background. MicroRNAs are small non-coding one-stranded RNA molecules that play an important role in the posttranscriptional regulation of genes. Bioinformatic predictions indicate that each miRNA can regulate hundreds of target genes. MicroRNA expression can be associated with various cellular processes leading to the metastasis of malignant tumours including non-small cell lung carcinoma. This review summarizes current knowledge on the role of microRNAs in NSCLC metastasis to the brain and lymph nodes. Metho… Show more

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Cited by 27 publications
(20 citation statements)
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References 185 publications
(175 reference statements)
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“…In recent years, ample evidences have revealed that the epigenetic regulation of miRNA alters the pathological progression and prognosis of lung cancer202122. Our latest studies indicated that altered eIF3a expression correlates with the prognosis of non-small lung cancer23 and that eIF3a expression was associated with the response of lung cancer patients to platinum-based chemotherapy through the regulation of DNA repair pathways24.…”
mentioning
confidence: 99%
“…In recent years, ample evidences have revealed that the epigenetic regulation of miRNA alters the pathological progression and prognosis of lung cancer202122. Our latest studies indicated that altered eIF3a expression correlates with the prognosis of non-small lung cancer23 and that eIF3a expression was associated with the response of lung cancer patients to platinum-based chemotherapy through the regulation of DNA repair pathways24.…”
mentioning
confidence: 99%
“…It can specifically bind with 3′-untranslated region (3′-UTR) in target mRNA, induce its degradation or inhibit its translation, so as to effectively silence the target gene protein expression at the post-transcriptional level [15, 16]. Studies have shown that miRNAs play an important role in the physiological and pathological processes, and are involved in all tumor related processes, such as tumorigenesis, differentiation, proliferation, apoptosis, invasion and metastasis [17, 18]. …”
Section: Introductionmentioning
confidence: 99%
“…2 Recent literatures showed that exosomes are closely related to tumor development and metastasis and even influence the therapeutic effect in cancer patients. 6,7 The stable presence of miRNAs in body fluids is partly because they are packed into microvesicles or exosomes. 8 Besides, miRNAs and mRNAs in exosomes are functional.…”
Section: Introductionmentioning
confidence: 99%