MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production

Zhang, Li; Zhang, Xiaoxin; Zhang, Xintong; Lu, Yu; Li, Lei; Cui, Sheng

doi:10.1530/joe-16-0488

Cited by 42 publications

(33 citation statements)

References 38 publications

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“…Understanding the expression patterns of miRNAs during the different phases of reproductive cycle (luteal or follicular phase) of mammals such as cattle would provide a better insight about post-transcriptional gene regulation underlining follicular atresia and oocyte ovulation [31,32] or to identify miRNAs governing the production of steroid essential for the normal processes of folliculogenesis [35][36][37][38][39]. Nevertheless, aberrant expression of developmentally relevant miRNAs during critical period of the reproductive cycle could negatively affect follicular development resulting for anovulation or ovulation of infertile oocytes.…”

Section: The Role Of Cellular Mirnas In Follicular Development and Oomentioning

confidence: 99%

The Role of MicroRNAs in Mammalian Fertility: From Gametogenesis to Embryo Implantation

Salilew‐Wondim

Gebremedhn

Hoelker

et al. 2020

IJMS

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The genetic codes inscribed during two key developmental processes, namely gametogenesis and embryogenesis, are believed to determine subsequent development and survival of adult life. Once the embryo is formed, its further development mainly depends on its intrinsic characteristics, maternal environment (the endometrial receptivity), and the embryo–maternal interactions established during each phase of development. These developmental processes are under strict genetic regulation that could be manifested temporally and spatially depending on the physiological and developmental status of the cell. MicroRNAs (miRNAs), one of the small non-coding classes of RNAs, approximately 19–22 nucleotides in length, are one of the candidates for post-transcriptional developmental regulators. These tiny non-coding RNAs are expressed in ovarian tissue, granulosa cells, testis, oocytes, follicular fluid, and embryos and are implicated in diverse biological processes such as cell-to-cell communication. Moreover, accumulated evidences have also highlighted that miRNAs can be released into the extracellular environment through different mechanisms facilitating intercellular communication. Therefore, understanding miRNAs mediated regulatory mechanisms during gametogenesis and embryogenesis provides further insights about the molecular mechanisms underlying oocyte/sperm formation, early embryo development, and implantation. Thus, this review highlights the role of miRNAs in mammalian gametogenesis and embryogenesis and summarizes recent findings about miRNA-mediated post-transcriptional regulatory mechanisms occurring during early mammalian development.

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Section: The Role Of Cellular Mirnas In Follicular Development and Oomentioning

confidence: 99%

The Role of MicroRNAs in Mammalian Fertility: From Gametogenesis to Embryo Implantation

Salilew‐Wondim

Gebremedhn

Hoelker

et al. 2020

IJMS

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show abstract

“…The localization and functional impact in the ovary of the abundant miR-143 was also undertaken ( 51 ). This miRNA was highly expressed in granulosa cells where it appeared to regulate E2 production but not that of P4.…”

Section: Regulation Of Ovarian Cycling By Mirnamentioning

confidence: 99%

Endocrine Regulation in the Ovary by MicroRNA during the Estrous Cycle

Toms

Pan

2018

Front. Endocrinol.

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Hormonal control of the estrous cycle that occurs in therian mammals is essential for the production of a functional egg. Supporting somatic cell types found within the ovary, such as granulosa and theca cells, respond to endocrine signals to support oocyte maturation and ovulation. Following the release of the egg, now available for fertilization, coordinated hormonal signaling between the mother and putative embryo are required for the establishment of pregnancy. If no conception occurs, both the ovary and uterus are “reset” in preparation for another cycle. The complex molecular changes that occur within cells in response to hormone signaling include a network of non-coding microRNAs (miRNAs) that posttranscriptionally regulate gene expression. They are thus able to fine-tune cellular responses to hormones and confer robustness in gene regulation. In this review, we outline the important roles established for miRNAs in regulating female reproductive hormone signaling during estrus, with a particular focus on signaling pathways in the ovary. Understanding this miRNA network can provide important insights to improving assisted reproductive technologies and may be useful in the diagnosis of female reproductive disorders.

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“…Increasing miRNAs are considered to be clinical biomarkers for atherosclerosis (Feinberg & Moore, ). Many recent studies have indicated that miRNAs can control a lot of fundamental biological processes (Rajman & Schratt, ; Zhang et al, ). For example, miR‐100 can inhibit chronic vascular inflammation by stimulating endothelial autophagy (Pankratz et al, ).…”

Section: Introductionmentioning

confidence: 99%

MiR‐181a inhibits vascular inflammation induced by ox‐LDL via targeting TLR4 in human macrophages

Yin

2018

Journal Cellular Physiology

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Atherosclerosis is a kind of chronic inflammation disease with lipid accumulation in in blood vessel linings. Increasing evidence has reported that microRNAs can exert crucial roles in atherosclerosis. In previous study, miR-181a has been implicated to be abnormally expressed in atherosclerosis mice, however its detailed function in atherosclerosis remains uninvestigated. Hence, in our current study, we focused on the biological role of miR-181a in atherosclerosis progression. Ox-LDL has been commonly identified as an important atherosclerosis regulator. We observed that ox-LDL induced THP-1 cell apoptosis dose-dependently and time- dependently. Meanwhile, 25 µg/ml ox-LDL can promote foam cell formation and increased miR-181a expression significantly. CD36 has been involved in atherosclerosis progression and it was found that overexpression of miR-181a inhibited its protein levels. Moreover, miR-181a mimics repressed foam cell formation, TC and TG levels induced by ox-LDL dramatically. In addition, miR-181a mimics were able to reverse THP-1 cell apoptosis, increased IL-6, IL-1β, and TNF-α protein expression triggered by 25 µg/ml ox-LDL. TLR4 has been linked to various inflammation-associated diseases. In our present study, TLR4 was indicated as miR-181a target and the binding correlation between them was validated by dual-luciferase reporter assay. In conclusion, these results improves the understanding of atherosclerosis modulated by miR-181a/TLR4 and can contribute to development of new approaches for atherosclerosis.

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MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production

Cited by 42 publications

References 38 publications

The Role of MicroRNAs in Mammalian Fertility: From Gametogenesis to Embryo Implantation

The Role of MicroRNAs in Mammalian Fertility: From Gametogenesis to Embryo Implantation

Endocrine Regulation in the Ovary by MicroRNA during the Estrous Cycle

MiR‐181a inhibits vascular inflammation induced by ox‐LDL via targeting TLR4 in human macrophages

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