mircoRNA-3162-3p is a potential biomarker to identify new infections in HIV-1-infected patients

Huang, Jiegang; Lai, Jingzhen; Liang, Bingyu; Jiang, Junjun; Ning, Chuanyi; Liao, Yulin; Zang, Ning; Wang, Minlian; Qin, Fengxiang; Yu, Jun; Wei, Wudi; Li, Ye; Liang, Hao

doi:10.1016/j.gene.2018.04.002

Cited by 12 publications

(9 citation statements)

References 32 publications

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“…In some cases, miRNA expression in PBMC appears dependent on viral load; of the 191 differentially expressed miRNAs identified by Duskova et al (2013), four were consistently different between clinical groups based on viral load, with miR-1262 independent of viral load but miR-1275, miR-483-5p, and miR-650 showing particular upregulation during high viremia (20). In plasma, differential expression of circulating miR-3162-3p was able to distinguish acute HIV infection from chronic infection and healthy controls; other molecules differentially expressed between these clinical groups were not discussed further (31).…”

Section: Results: the Gene Expression Of Hiv-driven Immunological Damage Hiv Impact On Gene Expression Of Mixed Cell Populationsmentioning

confidence: 97%

“…This stage is characterized by a rapid increase in HIV viral load, an early decline in CD4 ϩ T cells, acute inflammation, and often a transient flu-like illness. In practical terms, definitions of acute (27)(28)(29), early (18,(30)(31)(32), and primary (33) HIV are not absolute and vary greatly in the literature. Overall, there is a paucity of information regarding transcriptomic dysregulation during the earliest stages of HIV infection, including acute HIV infection; this is reflective of the nonspecific presentation of the earliest stages of HIV and the diagnostic and recruitment dilemmas this poses.…”

Section: Results: the Gene Expression Of Hiv-driven Immunological Damage Hiv Impact On Gene Expression Of Mixed Cell Populationsmentioning

confidence: 99%

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Gene Expression: the Key to Understanding HIV-1 Infection?

Judge

Parker

Naniche

et al. 2020

Microbiol Mol Biol Rev

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SUMMARY Gene expression profiling of the host response to HIV infection has promised to fill the gaps in our knowledge and provide new insights toward vaccine and cure. However, despite 20 years of research, the biggest questions remained unanswered. A literature review identified 62 studies examining gene expression dysregulation in samples from individuals living with HIV. Changes in gene expression were dependent on cell/tissue type, stage of infection, viremia, and treatment status. Some cell types, notably CD4+ T cells, exhibit upregulation of cell cycle, interferon-related, and apoptosis genes consistent with depletion. Others, including CD8+ T cells and natural killer cells, exhibit perturbed function in the absence of direct infection with HIV. Dysregulation is greatest during acute infection. Differences in study design and data reporting limit comparability of existing research and do not as yet provide a coherent overview of gene expression in HIV. This review outlines the extraordinarily complex host response to HIV and offers recommendations to realize the full potential of HIV host transcriptomics.

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Section: Results: the Gene Expression Of Hiv-driven Immunological Damage Hiv Impact On Gene Expression Of Mixed Cell Populationsmentioning

confidence: 97%

Section: Results: the Gene Expression Of Hiv-driven Immunological Damage Hiv Impact On Gene Expression Of Mixed Cell Populationsmentioning

confidence: 99%

Gene Expression: the Key to Understanding HIV-1 Infection?

Judge

Parker

Naniche

et al. 2020

Microbiol Mol Biol Rev

View full text Add to dashboard Cite

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“…For an in-depth review of ROC curves in evaluating diagnostic test accuracy, please see Hajian-Tilaki (2013). MicroRNA-3162-3p abundance in plasma from HIV patients was shown to differentiate new (<1 year post-infection) from old (>1 year) infections (Huang et al, 2018). Interestingly, a study by Yahyaei et al (2016) found that miR-223 and -29a were elevated in individuals that were repeatedly exposed to HIV but did not contract a productive infection.…”

Section: Advantages Of Mirna Biomarkers I: Early Detectionmentioning

confidence: 99%

MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing

et al. 2020

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In the pursuit of improved diagnostic tests for infectious diseases, several classes of molecules have been scrutinized as prospective biomarkers. Small (18-22 nucleotide), non-coding RNA transcripts called microRNAs (miRNAs) have emerged as promising candidates with extensive diagnostic potential, due to their role in numerous diseases, previously established methods for quantitation and their stability within biofluids. Despite efforts to identify, characterize and apply miRNA signatures as diagnostic markers in a range of non-infectious diseases, their application in infectious disease has advanced relatively slowly. Here, we outline the benefits that miRNA biomarkers offer to the diagnosis, management, and treatment of infectious diseases. Investigation of these novel biomarkers could advance the use of personalized medicine in infectious disease treatment, which raises important considerations for validating their use as diagnostic or prognostic markers. Finally, we discuss new and emerging miRNA detection platforms, with a focus on rapid, point-of-care testing, to evaluate the benefits and obstacles of miRNA biomarkers for infectious disease.

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“…They found that this particular miRNA was differentially expressed among these groups (Munshi et al, 2014). Similarly, in a very recent study, Huang et al (2018) collected plasma from healthy donors, patients infected for less than 1 year and patients infected for more than 1 year. Differential expression of miR-3162-3p was observed between these groups.…”

Section: The Relationship Between Mirnas and Disease Progression In Hmentioning

confidence: 99%

“…Differential expression of miR-3162-3p was observed between these groups. The clinical significance of this discovery was validated by successfully predicting disease progression based on the expression of the miRNA and in an in vitro model (Huang et al, 2018).…”

Section: The Relationship Between Mirnas and Disease Progression In Hmentioning

confidence: 99%

Potential Application of MicroRNA Profiling to the Diagnosis and Prognosis of HIV-1 Infection

Liu

et al. 2018

Front. Microbiol.

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MicroRNAs (miRNAs) were first identified in Caenorhabditis briggsae and later recognized as playing pivotal roles in a vast range of cellular activities. It has been shown that miRNAs are an important mechanism not only for host defense against virus but also for the establishment of viral infection. During human immunodeficiency virus type 1 (HIV-1) infection, host miRNA profiles are altered either as a host response against the virus or alternatively as a mechanism for the virus to facilitate viral replication and infection or to maintain latency. The altered miRNA profiles can be detected and quantified by various advanced assays, and potentially serve as more sensitive, accurate and cost-efficient biomarkers for HIV-1 diagnosis and disease progression than those detected by currently available standard clinical assays. Such new biomarkers are critical for optimizing treatment regimens. In this review, we focus on the potential application of miRNA profiling to the diagnosis of HIV-1 infection and the monitoring of disease progression.

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mircoRNA-3162-3p is a potential biomarker to identify new infections in HIV-1-infected patients

Cited by 12 publications

References 32 publications

Gene Expression: the Key to Understanding HIV-1 Infection?

Gene Expression: the Key to Understanding HIV-1 Infection?

MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing

Potential Application of MicroRNA Profiling to the Diagnosis and Prognosis of HIV-1 Infection

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