MIR196A2 rs11614913 contributes to susceptibility to colorectal cancer in Iranian population: A multi-center case-control study and meta-analysis

Haerian, Monir Sadat; Haerian, Batoul Sadat; Molanaei, Saadat; Kosari, Farid; Sabeti, Shahram; Bidari‐Zerehpoosh, Farahnaz; Abdolali, Ebrahim

doi:10.1016/j.gene.2018.05.082

Cited by 8 publications

(9 citation statements)

References 35 publications

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“…From the initial search in online databases, we identified a total of 1819 initial records for miR-196a2 rs11614913 polymorphism, from which 152 articles 13 – 41 , 48 …”

Section: Resultsmentioning

confidence: 99%

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Aziz

Akter

Islam

2022

Technol Cancer Res Treat

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Background: MiR-196a2 rs11614913 polymorphism has been studied in a wide range of cancers throughout the years. Despite a large number of epidemiological studies performed in almost all ethnic populations, the contribution of this polymorphism to cancer risk is still inconclusive. Therefore, this updated meta-analysis was performed to estimate a meticulous correlation between miR-196a2 rs11614913 variant and cancer susceptibility. Methods: A systematic study search was carried out using PubMed, ScienceDirect, CNKI, EMBASE, Scopus, and Google Scholar databases following PRISMA guidelines to find necessary literature up to December 15, 2021. Pooled odds ratios with corresponding 95% confidence intervals were estimated using RevMan 5.4 based on ethnicities, cancer types, control sources, and genotyping methods. Results: A total of 152 studies, including 120 135 subjects (53 818 patients and 66 317 controls; 140 studies, after removing studies that deviated from HWE: 51 459 cases and 62 588 controls), were included in this meta-analysis. Quantitative synthesis suggests that the miR-196a2 rs11614913 genetic variant is significantly correlated with the reduced risk of overall cancer in CDM2, CDM3, RM, and AM (odds ratio < 1 and P < .05). It is also observed from ethnicity-based subgroup analysis that rs11614913 polymorphism is significantly ( P < .05) linked with cancer in the Asian (in CDM2, CDM3, RM, AM) and the African population (in CDM1, CDM3, ODM). Stratified analysis based on the cancer types demonstrated a significantly decreased correlation for breast, hepatocellular, lung, and gynecological cancer and an increased association for oral and renal cell cancer. Again, the control population-based subgroup analysis reported a strongly reduced correlation for HB population in CDM2, RM, and AM. A substantially decreased risk was also observed for other genotyping methods in multiple genetic models. Conclusions: MiR-196a2 rs11614913 variant is significantly correlated with overall cancer susceptibility. Besides, rs11614913 is correlated with cancer in Asians and Africans. It is also correlated with breast, gynecological, hepatocellular, lung, oral, and renal cell cancer.

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“…From the initial search in online databases, we identified a total of 1819 initial records for miR-196a2 rs11614913 polymorphism, from which 152 articles 13 – 41 , 48 …”

Section: Resultsmentioning

confidence: 99%

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Aziz

Akter

Islam

2022

Technol Cancer Res Treat

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“…The localization of rs11614913 affects both the maturation of miRNA-196a-2 and its interactions [ 45 ]. Several studies link rs11614913 polymorphism with the risk of CRC [ 21 , 24 , 45 , 46 , 47 , 48 ]. On the other hand, 10 studies do not confirm this association [ 17 , 18 , 25 , 26 , 27 , 29 , 30 , 49 , 50 ].…”

Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

“…The T allele of rs11614913 in heterozygotes (CT vs. CC), homozygotes (TT vs. CC), and in an allelic model in the study by Lv et al (2013), or T allele in all genetic models in the studies by Toraih et al (2016) and Haerian et al (2018) was associated with a high risk of CRC [ 21 , 47 , 48 ]. Interestingly, in the study by Toraih et al (2016) the authors reported that the T allele was susceptible to CRC, although the carriers of the C allele had higher expression levels of mature miRNA-196a-2.…”

Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

“…The study of Haerian et al (2018) presented new data from their study on Iranian Caucasians, and in the subsequent meta-analysis, authors found a significant association of rs11614913 and CRC in Caucasians. In contrast, in Asians, and overall, the polymorphism was not relevant to CRC [ 47 ]. Moreover, Haerian et al, 2018 showed that the T allele was a risk factor for CRC, which was reported as protective against the disease in other meta-analyses.…”

Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

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Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

et al. 2022

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There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-invasive biomarkers for early detection of CRC. In the present article, we performed a thorough review of different SNPs, which were investigated for a correlation with the CRC risk, prognosis, and treatment response. We also analyzed the results from different meta-analyses and the possible reasons for reported contradictory findings, especially when different research groups investigated the same SNP in a gene for a particular miRNA. This illustrates the need for more case-control studies involving participants with different ethnic backgrounds. According to our review, three miRNAs-SNPs—miR-146a rs2910164, miR-27a rs895819 and miR-608 rs4919510—appear as promising prognostic, diagnostic and predictive biomarkers for CRC, respectively.

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“…We have read the article, "MIR196A2 rs11614913 contributes to susceptibility to colorectal cancer in Iranian population: A multi-center case-control study and meta-analysis", published in the August 2018 edition of the journal, with great interest (Haerian et al, 2018). However, we would like to suggest a few improvements to observed oversights in the article, which hamper the utility of the study.…”

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confidence: 99%

Letter to the Editor regarding, “MIR196A2 rs11614913 contributes to susceptibility to colorectal cancer in Iranian population: A multi-center case-control study and meta-analysis”

Jayaraj

Kumarasamy

Gothandam

et al. 2019

Gene

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MIR196A2 rs11614913 contributes to susceptibility to colorectal cancer in Iranian population: A multi-center case-control study and meta-analysis

Cited by 8 publications

References 35 publications

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Effect of miR-196a2 rs11614913 Polymorphism on Cancer Susceptibility: Evidence From an Updated Meta-Analysis

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

Letter to the Editor regarding, “MIR196A2 rs11614913 contributes to susceptibility to colorectal cancer in Iranian population: A multi-center case-control study and meta-analysis”

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