MiR-BART2-3p targets Unc-51-like kinase 1 and inhibits cell autophagy and migration in Epstein-Barr virus-associated gastric cancer

Shi, Duo; Zhang, Yan; Mao, Tao; Liu, Dandan; Li, Wen; Luo, Bing

doi:10.1016/j.virusres.2021.198567

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Furthermore, miR-133a-3p is found to target GABARAPL1 to block autophagy-mediated glutaminolysis, thereby repressing GC cell growth and metastasis (77). Similar effects are observed in Epstein-Barr virus-associated GC where miR-BART2-3p is elevated to attenuate autophagy and further reduce epithelialmesenchymal transition (EMT) and cell migration by targeting ULK1 (78). These findings indicate that tumor-suppressive miRNAs inhibit GC progression by suppressing cytoprotective autophagy via targeting autophagy-related components.…”

Section: Tumor Suppressormentioning

confidence: 68%

Regulation of autophagy by non-coding RNAs in gastric cancer

Wang

Liu²,

Xie³

et al. 2022

Front. Oncol.

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Autophagy is a conserved cellular self-digesting process that degrades obsoleting proteins and cellular components and plays a crucial role in the tumorigenesis, metastasis, and drug resistance of various tumors such as gastric cancer (GC). As a hotspot in molecular biology, non-coding RNAs (ncRNAs) are involved in the regulation of multiple biological processes, such as autophagy. Increasing evidence indicate that various ncRNAs exert double roles in the initiation and progression of GC, either serve as oncogenes or tumor suppressors. Recent studies have shown that some ncRNAs could modulate autophagy activity in GC cells, which would affect the malignant transformation and drug resistance. Whether the function of ncRNAs in GC is dependent on autophagy is undefined. Therefore, identifying the underlying moleculr targets of ncRNAs in autophagy pathways and the role of ncRNA-regulated autophagy in GC could develop new treatment interventions for this disease. This review summarizes the autophagy process and its role in GC, and the regulatory mechanisms of ncRNAs, as well as focuses on the dual role of ncRNAs-mediated autophagy in GC, for the development of potential therapeutic strategies in GC patients.

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Section: Tumor Suppressormentioning

confidence: 68%

Regulation of autophagy by non-coding RNAs in gastric cancer

Wang

Liu²,

Xie³

et al. 2022

Front. Oncol.

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“…Recent investigations have demonstrated that EBV-miR-BART2-3p targets Unc-51-like kinase 1 (ULK1), resulting in a decline in protein markers associated with epithelial-mesenchymal transformation (EMT) as well as a diminishment of EMT and migration [ 53 ]. In this regard, EBV-miR-BART2-3p may be participating in the inhibition of autophagy.…”

Section: Discussionmentioning

confidence: 99%

Novel plasma microRNA expression features in diagnostic use for Epstein-Barr virus-associated febrile diseases

Xu,

Chen,

Yang

et al. 2024

Heliyon

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“…MiR-BART12 targeted and accelerated the degradation of Zinc finger protein SNAI 1 (Snail), one of the EMT inducers, consequently repressing cell proliferation and migration (35). Similarly, MiR-BART2-3p was demonstrated to reduce cell migration through inhibition of Unc-51-like kinases 1 (ULK1) which may reduce the expression of bcatenin, N-cadherin, and ZEB1 (36). Moreover, Baoyu He et al indicated that miR-BART6-3p downregulated long non-coding RNA (lncRNA) LOC553103, reversing the EMT process and suppressing the migration and invasion of cancer cells (37).…”

Section: Migrationmentioning

confidence: 99%

“…EBV-encoded miRNAs have been implicated in the promotion of malignant transformation of cells, potentially via their involvement in autophagy. Unc-51-like kinase 1 (ULK1) is a serine/threonine protein kinase that plays an important role in autophagy initiation ( 36 ). According to Duo Shi et al., luciferase reporter assay revealed that miR-BART2-3p directly targets ULK1, leading to decreased expression of autophagy-related proteins.…”

Section: The Role Of Ebv-encoded Mirna In Ebvagcmentioning

confidence: 99%

The role of EBV-encoded miRNA in EBV-associated gastric cancer

et al. 2023

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Epstein-Barr virus (human herpesvirus 4, EBV) is a linear double-stranded DNA virus that infects over 90% of the population worldwide. However, our understanding of EBV’s contribution to tumorigenesis of EBV-associated GC (EBVaGC) remains incomplete. Recent advancements in EBVaGC research have highlighted that EBV-encoded microRNAs (miRNAs) play prominent roles in critical cellular processes such as migration, cell cycle, apoptosis, cell proliferation, immune response, and autophagy. Notably, the largest group of EBV-encoded miRNAs, known as BamHI-A rightward transcripts (BARTs), exhibit bidirectional effects in EBVaGC. For instance, they present both anti-apoptotic and pro-apoptotic functions and enhance chemosensitivity while also conferring resistance to 5-fluorouracil. Despite these findings, the comprehensive mechanisms through which miRNAs contribute to EBVaGC are yet to be fully elucidated. In this work, we summarize the current evidence of the roles of miRNA in EBVaGC, particularly with the application of multi-omic techniques. Additionally, we discuss the application of miRNA in EBVaGC in retrospective analyses and provide novel perspectives on the use of miRNA in EBVaGC in translational medicine.

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MiR-BART2-3p targets Unc-51-like kinase 1 and inhibits cell autophagy and migration in Epstein-Barr virus-associated gastric cancer

Cited by 5 publications

References 33 publications

Regulation of autophagy by non-coding RNAs in gastric cancer

Regulation of autophagy by non-coding RNAs in gastric cancer

Novel plasma microRNA expression features in diagnostic use for Epstein-Barr virus-associated febrile diseases

The role of EBV-encoded miRNA in EBV-associated gastric cancer

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