“…13 In addition, recent studies also showed that miR-802 acted as a tumor suppressor in gastric cancer, non-small cell lung cancer, epithelial ovarian cancer, laryngeal cancer, tongue squamous cell carcinoma and glioblastoma via, respectively, suppressing down-stream multiple oncogenes expression, including RAB23, FGFR1, YWHAZ, ARPP19, MAP2K4 or SIX4. 12,[15][16][17]20,24 Herein, our clinical results showed that miR-802 was significantly down-regulated in CRC tissues, and lower miR-802 expression was apparently associated with poorer tumor grade, later T stage, later N stage and advanced TNM stage and worse patient's OS. Furthermore, elevated expression of miR-802 suppressed CRC cells proliferation, migration and invasion while enhanced the apoptosis of CRC cells by directly targeting UBN2 both in vitro and in vivo.…”