miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR

Xu, Ning; Lian, Yanjun; Dai, Xiujuan J.; Wang, Yuanjie

doi:10.1177/1533034617717863

Cited by 24 publications

(26 citation statements)

References 25 publications

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“…In addition, it was identified that mTOR was a direct target gene of miR-7 in bladder cancer cells, and that the overexpression of mTOR abolished the miR-7-induced inhibition of bladder cancer cell proliferation, migration and invasion. In fact, this targeting relationship has also been reported in several other types of human cancer ( 29 , 30 ). For example, miR-7 increases cisplatin sensitivity of gastric cancer cells by suppressing the expression of mTOR ( 29 ).…”

Section: Discussionsupporting

confidence: 64%

“…In fact, this targeting relationship has also been reported in several other types of human cancer ( 29 , 30 ). For example, miR-7 increases cisplatin sensitivity of gastric cancer cells by suppressing the expression of mTOR ( 29 ). Glover et al ( 30 ) reported that miR-7 functioned as a tumor suppressor and novel therapeutic agent for adrenocortical carcinoma by targeting mTOR and RAF1.…”

Section: Discussionsupporting

confidence: 64%

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lncRNA TINCR facilities bladder cancer progression via regulating miR‑7 and mTOR

Yang

Liu

et al. 2020

Mol Med Rep

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Long non-coding RNAs (lncRNAs) have been implicated in various human malignancies, but the molecular mechanism of lncRNA TINCR ubiquitin domain containing (TINCR) in bladder cancer remains unclear. The present study found that the expression of TINCR was significantly increased in bladder cancer tissues and cell lines, when compared with that in adjacent normal tissues and normal urinary tract epithelial cell line SV-HUC-1, respectively. Moreover, the high expression of TINCR was associated with tumor metastasis and advanced tumor, node, metastasis stage, as well as reduced overall survival rates of patients with bladder cancer. Further investigation revealed that microRNA (miR)-7 was negatively mediated by TINCR in bladder cancer cells. Silencing of TINCR expression significantly increased miR-7 expression and reduced bladder cancer cell proliferation, migration and invasion, while knockdown of miR-7 expression reversed the inhibitory effects of TINCR downregulation on bladder cancer cells. mTOR was then identified as a target gene of miR-7 in bladder cancer, and it was demonstrated that overexpression of mTOR reversed the inhibitory effects of miR-7 on bladder cancer cells. In conclusion, this study suggests that TINCR/miR-7/mTOR signaling may be a potential therapeutic target for bladder cancer.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionsupporting

confidence: 64%

lncRNA TINCR facilities bladder cancer progression via regulating miR‑7 and mTOR

Yang

Liu

et al. 2020

Mol Med Rep

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“…A decrease in drug resistance can be achieved through miR-130a, miR-100 and miR-199a's modulation of the expression of the mTOR pathway in ovarian cancer 85 - 87 . In gastric cancer, miR-224 can promote the development of cell growth and metastasis through activation of the mTOR pathway 88 , 89 . Inversely, miR-370 could inhibit tumorgenesis by restraining the mTOR pathway of gastric cancer cells 90 , 91 .…”

Section: Mtor Signaling Pathway and Cancersmentioning

confidence: 99%

mTOR signaling-related MicroRNAs and Cancer involvement

et al. 2018

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MicroRNAs (miRNAs) are a class of single-stranded RNAs, 18-23 nucleotides in length that regulate gene expression at the post-transcriptional level. Dysregulation of miRNAs has been closely associated with the development of cancer. In the process of tumorigenesis, mammalian target of rapamycin (mTOR) plays important roles, and the mTOR signaling pathway is aberrant in various types of human cancers, including non-small cell lung cancer (NSCLC), breast cancer, prostate cancer, as well as others. However, the relationship between miRNAs and the mTOR signaling pathway is indistinct. Herein, we not only summarize the progress of miRNAs and the mTOR signaling pathway in cancers, but also highlight their role in the diagnosis and treatment in the clinic.

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“…Recently, miR-7 has been reported to play an important role in regulating the biological process of various diseases [46,47]. For instance, miR-7 is a tumor suppressor and increase cisplatin sensitivity of gastric cancer cells by targeting mTOR, indicating its potential application for the treatment of human gastric cancer in the future [48]. Moreover, miR-7 can regulate α-synuclein expression and downregulation of miR-7 results in the loss of dopaminergic neuronal in the substantia nigra [49].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation

Yue

Zhao

Chen

et al. 2020

J Neuroinflammation

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Background: Accumulating evidence has documented that microRNA-7 (miR-7) plays an important role in the pathology of various diseases. However, the potential role of miR-7 in brain tissue inflammation (BTI) remains unclear. Methods: We detected the expression of miR-7 in LPS-induced murine BTI model and observed the possible effects of miR-7 deficiency on the pathology of BTI. To elucidate the mechanism, the target gene of miR-7 was screened out by Gene chip assay and its potential roles in BTI were evaluated by Western blot, immunofluorescence, and RNAi assay, respectively.Results: MiR-7 was upregulated in brain tissue in BTI mice and its deficiency could significantly aggravate the pathology of brain tissue. Moreover, RORα, a new target molecule of miR-7, was upregulated in brain tissue from miR-7 deficiency BTI mice. Of note, downregulation of RORα could remarkably exacerbate the pathology of brain tissue and elevate the transduction of NF-κB and ERK1/2 signaling pathways in brain tissue from miR-7 deficiency BTI mice. Furthermore, RORα and miR-7 were dominantly co-expressed in neurons of BTI mice. Finally, RORα synergized with miR-7 to control the inflammatory reaction of neuronal cells in response to LPS stimulation.Conclusions: MiR-7 expression is upregulated in BTI model. Moreover, miR-7 synergizes with its target gene RORα to control the inflammation reaction of neurons, thereby orchestrating the pathology of BTI.

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miR-7 Increases Cisplatin Sensitivity of Gastric Cancer Cells Through Suppressing mTOR

Cited by 24 publications

References 25 publications

lncRNA TINCR facilities bladder cancer progression via regulating miR‑7 and mTOR

lncRNA TINCR facilities bladder cancer progression via regulating miR‑7 and mTOR

mTOR signaling-related MicroRNAs and Cancer involvement

MicroRNA-7, synergizes with RORα, negatively controls the pathology of brain tissue inflammation

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