miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli

Shu, Zhenbo; Chen, Libo; Ding, Dayong

doi:10.1186/s12957-016-0984-4

Cited by 20 publications

(24 citation statements)

References 29 publications

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“…Interestingly, several lines of evidence have reported that miR-582-3p and miR-582-5p simultaneously act as oncogene or tumor suppressor in different types of cancer. In colorectal cancer and non-functioning pituitary adenomas, miR-582-3p and miR-582-5p expression were simultaneously upregulated and function as oncogenic miRNA 37, 39, 41. Conversely, miR-582-3p and miR-582-5p expression have been reported to be strongly decreased in bladder cancer tissues, in which they played tumor-suppressive roles 45 .…”

Section: Discussionmentioning

confidence: 99%

miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGF-β Signaling

Huang

Zou

Tang

et al. 2019

Molecular Therapy - Nucleic Acids

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A number of studies have reported that aberrant expression of microRNAs (miRNAs) closely correlates with the bone metastasis of prostate cancer (PCa). However, clinical significance and functional roles of both strands of a single miRNA in bone metastasis of PCa remain undefined. Here, we reported that miR-582-3p and miR-582-5p expression were simultaneously reduced in bone metastatic PCa tissues compared with non-bone metastatic PCa tissues. Downexpression of miR-582-3p and miR-582-5p strongly and positively correlated with advanced clinicopathological characteristics and shorter bone metastasis-free survival in PCa patients. Upregulating miR-582-3p and miR-582-5p inhibited invasion and migration abilities of PCa cells in vitro, as well as repressed bone metastasis in vivo. Our results further revealed that miR-582-3p and miR-582-5p attenuated bone metastasis of PCa via inhibiting transforming growth factor β (TGF-β) signaling by simultaneously targeting several components of TGF-β signaling, including SMAD2, SMAD4, TGF-β receptor I (TGFBRI), and TGFBRII. Moreover, deletion contributes to miR-582-3p and miR-582-5p downexpression in PCa tissues. Finally, clinical negative correlations of miR-582-3p and miR-582-5p with SMAD2, SMAD4, TGFBRI, and TGFBRII were demonstrated in PCa tissues. Thus, our findings explore a novel tumor-suppressive miRNA with its both strands implicated in bone metastasis of PCa, suggesting its potential therapeutic value in treatment of PCa bone metastasis.

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Section: Discussionmentioning

confidence: 99%

miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGF-β Signaling

Huang

Zou

Tang

et al. 2019

Molecular Therapy - Nucleic Acids

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“…Study by Maeno et al demonstrated that up-regulation of miR-582-5p facilitated cellular proliferation of prostate cancer cells under androgen-deprived conditions[11]. In colorectal cancer, miR-582-5p has showed to elevate cell growth rate by targeting adenomatous polyposis coli (APC)[26]. The exact function of miR-582-5p in NSCLC remains unknown.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-582-5p suppresses non-small cell lung cancer cells growth and invasion via downregulating NOTCH1

Liu

Deng

et al. 2019

PLoS ONE

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Non-small cell lung cancer (NSCLC) is the most common cancer worldwide. MicroRNAs have been shown to be correlated with biological processes of various tumors. In this study, we observed that the expression of miR-582-5p was lower in NSCLC tissues than that in para-carcinoma tissues. Ectopic expression of miR-582-5p significantly inhibited NCI-H358 cell proliferation and invasion. Knockdown of miR-582-5p showed the opposite results, with cell growth rate and the invasive capacity of PC-9 cells enhanced. Furthermore, we elucidated that NOTCH1 is a target of miR-582-5p and there is an inverse correlation between miR-582-5p and NOTCH1 expression in NSCLC tissues. Overexpression of NOTCH1 in miR-582-5p-overexpressing NCI-H358 cells could partially reverse the inhibition of cell proliferation and invasion by miR-582-5p. Thus, our research demonstrated that miR-582-5p suppresses NSCLC cell lines’ growth and invasion via targeting oncoprotein NOTCH1 and restoration of miR-582-5p might be feasible therapeutic strategy for NSCLC.

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“…miRNAs regulate a variety of biological processes and they exert their functions under both physiological and pathological conditions, including cell proliferation, apoptosis, development and metabolism (22). To date, many studies have reported that miRNAs are associated with colon tumors.…”

Section: Discussionmentioning

confidence: 99%

Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase�6

Song

Wang

et al. 2018

Oncol Rep

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Colorectal cancer is one of the most common types of malignancies worldwide, and as it is often diagnosed at an advanced stage, it is a serious threat to human health. MicroRNAs are important regulators of the growth and metastasis of colon cancer (CC). In the present study, the results demonstrated that kallikrein‑related peptidase 6 (KLK6) plays a critical role in suppressing colon carcinoma progression. To further investigate whether microRNAs affect the impact of KLK6, a bioinformatics approach was employed, which indicated that let‑7i‑5p may directly target KLK6. Furthermore, the expression level of let‑7i‑5p was significantly negatively correlated with the expression of KLK6 at the mRNA and protein levels in CC. Functionally, overexpression of let‑7i‑5p inhibited the proliferation and invasion of CC cells, and suppressed the growth of CC in vitro. The luciferase reporter assays revealed that let‑7i‑5p targeted the KLK6 3'‑untranslated region. Collectively, these results indicated that let‑7i‑5p inhibited the proliferation and metastasis of CC cells by targeting KLK6, thereby blocking the cell cycle and promoting apoptosis in colon cells. Therefore, the present study revealed that the let‑7i‑5p/KLK6 axis may be a potential target for new therapeutic strategies to treat colon tumors.

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miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli

Cited by 20 publications

References 29 publications

miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGF-β Signaling

miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGF-β Signaling

MicroRNA-582-5p suppresses non-small cell lung cancer cells growth and invasion via downregulating NOTCH1

Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase�6

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