MiR-548-3p functions as an anti-oncogenic regulator in breast cancer

Shi, Yafei; Qiu, Min; Wu, Yanyan; Lü, Hai

doi:10.1016/j.biopha.2015.07.027

Cited by 66 publications

(65 citation statements)

References 15 publications

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“…Downstream targets of the miRNA 548 family have been shown to be involved in breast cancer, inflammatory responses and potential oestrogen receptor sensitivity 19, 23, 31 and therefore, all have a potential biological role in the setting of preterm birth. Furthermore, miR548 associated target genes have previously been implicated in having a role in breast cancer and immune response 19, 23, 31, 32 . Studies have shown that down-regulation mir548 target genes that have been previously observed to be related to colorectal cancer aetiology.…”

Section: Discussionmentioning

confidence: 99%

Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study

Gray

McCowan

Patel

et al. 2017

Sci Rep

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More than 10% of babies are born too early resulting in over 15 million preterm births and more than one million new-born deaths globally. Although women with a previous spontaneous preterm birth (SPTB) are considered at high risk for recurrence, the majority occur in women without prior history. Prediction of SPTB risk allows for improved care and potential for targeting novel and existing therapeutics to prevent SPTB, which may result in improved outcomes for infant and mother. In this pilot study, a miRNA array was used to analyse plasma from healthy women in their first pregnancy at 20 weeks of gestation who then went on to deliver either at term or experience SPTB at 28–32 weeks. We identified specific miRNA expression profiles that differentiated between those mothers who delivered at term or delivered following SPTB. miR302b, miR1253 and a clustering of miR548 miRNAs were underexpressed in SPTB cases compared to term controls. Conversely, miR223 was elevated in mothers that later experienced a SPTB. The circulating miRNAs identified in the present study may therefore be attractive candidates as non-invasive biomarkers for the early prediction of SPTB. Further larger studies are now warranted to investigate the potential clinical utility of these markers.

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Section: Discussionmentioning

confidence: 99%

Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study

Gray

McCowan

Patel

et al. 2017

Sci Rep

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“…Inhibition of hsa‐miR‐362‐5p (cfa‐miR‐362 homologue) has been shown to decrease the proliferation, migration and invasion of MCF7 breast cancer cells, and the growth and metastasis of hepatocellular carcinoma cells in vivo . Conversely, down‐regulation of hsa‐miR‐124‐3p (homologue of cfa‐miR‐124) in numerous cancers and hsa‐miR‐548c‐3p (mml‐miR‐548c homologue) in breast cancer implies a metastasis suppressor role.…”

Section: Discussionmentioning

confidence: 99%

Metastasis‐associated microRNA expression in canine uveal melanoma

Starkey

Compston‐Garnett

Malho

et al. 2017

Vet Comparative Oncology

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“…It has been observed that miR-548-3p was downregulated in clinical specimens and in breast cancer cell lines. Moreover, overexpression of miR-548-3p inhibited the proliferation and promoted the apoptosis of breast cancer cells (Shi et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients' Smoking Status

Bruzgielewicz

Osuch-WojcikiewiczEwa

NiemczykKazimierz

et al. 2017

DNA and Cell Biology

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It has been reported that microRNAs (miRNAs) are responsible for acquiring all the hallmarks of cancer cells, as well as have a significant impact on the clinical management of cancers at every stage, including prognosis, remission, relapse, and metastasis. In this study, we investigated the association of miR-29a-3p, miR-202-3p, miR-3713, miR-4768-3p, and miR-548aa expression with clinicopathologic features in patients suffering from laryngeal cancer (LC) and determined the potential role of studied miRNAs in the progression of LC. The study group consisted of 48 patients with untreated primary tumors of head and neck cancer localized in the larynx. Expression of the selected miRNAs was verified by the qRT-PCR technique. We showed that the expression of miR-29a as well as miR-548aa was positively correlated with tumor stage and lymph node metastasis, whereas the expression of miR-4768-3p was negatively correlated with lymph node metastasis. Furthermore, we investigated that exposure to cigarette smoke altered miRNA expression profile in LC. The expression level of miR-202-3p was significantly increased in smoking patients compared with nonsmokers, whereas the miR-4768-3p, miR-548aa, and miR-3713 were markedly decreased. Our research contributed toward better elucidating the mechanisms underlying the progression of LC as well as the use of miRNAs inhibitors as novel agents against progression and metastasis of LC.

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MiR-548-3p functions as an anti-oncogenic regulator in breast cancer

Cited by 66 publications

References 15 publications

Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study

Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study

Metastasis‐associated microRNA expression in canine uveal melanoma

Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients' Smoking Status

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