miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling

Cen, Wenjian; Yan, Qin; Zhou, Wenpeng; Mao, Minjie; Huang, Qitao; Lin, Yaobin; Jiang, Neng

doi:10.1007/s13402-023-00848-z

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…AXIN2 expression was downregulated by a short peptide encoded by lncRNA DLX6-AS1, which is able to activate Wnt/β-catenin pathway in NSCLC cells [ 94 ]. MicroRNAs which downregulated APC expression include miR-4326 [ 95 ], miR-3607 [ 96 ] and miR-4739 [ 97 ] (Table 2 ). At the protein level, APC can be ubiquitinated by RNF115 and undergoes proteasomal degradation [ 98 ].…”

Section: The Positive Regulators Of Wnt/β-catenin Signalingmentioning

confidence: 99%

Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer

Zhang,

Westover,

Tang

et al. 2024

J Transl Med

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Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, and circRNAs, have been found to promote or inhibit signaling by acting on Wnt proteins, receptors, signal transducers and transcriptional effectors. The identification of these regulators and their underlying molecular mechanisms provides important implications for how to target this pathway therapeutically. In this review, we summarize recent studies of Wnt regulators in the development and therapeutic response of NSCLC.

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Section: The Positive Regulators Of Wnt/β-catenin Signalingmentioning

confidence: 99%

Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer

Zhang,

Westover,

Tang

et al. 2024

J Transl Med

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Research trend of lung cancer epigenetics research: Bibliometric and visual analysis of top-100 cited documents

Lou,

2024

Heliyon

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Unraveling the Connection: Extracellular Vesicles and Non-Small Cell Lung Cancer

Wu,

Chen

2024

IJN

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Extracellular vesicles (EVs) are nanoscale lipid bilayer vesicles released during cell activation, cellular damage, or apoptosis. They carry nucleic acids, proteins, and lipids facilitating intercellular communication and activate signaling pathways in target cells. In non-small cell lung cancer (NSCLC), EVs may contribute to tumor growth and metastasis by modulating immune responses, facilitating epithelial-mesenchymal transition, and promoting angiogenesis, while potentially contributing to resistance to chemotherapy drugs. EVs in liquid biopsies serve as non-invasive biomarkers for early cancer detection and diagnosis. Due to their small size, inherent molecular transport properties, and excellent biocompatibility, EVs also act as natural drug delivery vehicles in NSCLC therapy.

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miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling

Cited by 4 publications

References 62 publications

Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer

Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer

Research trend of lung cancer epigenetics research: Bibliometric and visual analysis of top-100 cited documents

Unraveling the Connection: Extracellular Vesicles and Non-Small Cell Lung Cancer

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