Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer
Zixu Zhang,
David Westover,
Zhantong Tang
et al.
Abstract:Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators, including proteins, miRNAs, lncRNAs, and circRNAs, have been found to promote or inhibit signaling by acting on Wnt proteins, receptors, signal transducers and transcriptional effectors. The identification of these regulators and their underlying molecular mechanisms provides important implications for how to target this pathway therapeu… Show more
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