MiR-455-5p acts as a novel tumor suppressor in gastric cancer by down-regulating RAB18

Liu, Jichao; Zhang, Jiakui; Li, Yongshuang; Wang, Lei; Sui, Baiqiang; Dai, Dong‐Qiu

doi:10.1016/j.gene.2016.07.034

Cited by 54 publications

(47 citation statements)

References 28 publications

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“…Previous studies have reported that miRNAs directly interact with their targets to regulate tumor progression (12). In gastric cancer, miR-455-5p acts as a tumor suppressor via targeting and downregulating RAB18, member RAS oncogene family RAB18 (13). The present study demonstrated that miR-455-5p targeted and negatively regulated programmed cell death (PDCD)4, which has been identified as a tumor suppressor in breast cancer, and inhibits breast cancer cell migration, invasion and growth.…”

Section: Introductionsupporting

confidence: 58%

“…Wu et al (21) suggested that in breast cancer, miR-613 negatively regulates vascular endothelial growth factor expression and restrains the cell proliferation and invasion. Notably, miR-455-5p has been identified as an oncogene or anti-oncogene in previous studies (11,13,22). In gastric cancer, miR-455-5p has been identified as a tumor suppressor, which decreases the expression of RAB18 (13).…”

Section: Discussionmentioning

confidence: 98%

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miR‑455‑5p promotes cell invasion and migration in breast cancer

2017

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MicroRNA (miR)‑455‑5p has been identified as a biomarker for various types of cancer and may therefore be involved in the regulation of cancer development and progression. However, the specific role and function of miR‑455‑5p in breast cancer remains unclear. The present study explored the expression levels and function of miR‑455‑5p in breast cancer. The results from reverse transcription‑quantitative polymerase chain reaction analysis revealed that miR‑455‑5p was significantly upregulated in breast cancer. Clinically, increased expression of miR‑455‑5p predicted a poor survival rate and miR‑455‑5p was identified as one of the independent prognostic factors for breast cancer patients. Furthermore, results from wound healing and Transwell assays revealed that miR‑455‑5p accelerated invasiveness and migration capabilities of breast cancer cells. In addition, programmed cell death 4 was identified as a downstream target of miR‑455‑5p and its expression was observed to be negatively regulated by miR‑455‑5p. Overall, miR‑455‑5p may function as an oncogene in breast cancer, and may therefore be used as a prognostic marker for breast cancer patients.

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Section: Introductionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 98%

miR‑455‑5p promotes cell invasion and migration in breast cancer

2017

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“…MiRNA-455 (miR-455) is recognized as a broadly conserved noncoding RNA that has been implicated in various cancers. The function of miR-455 has been confirmed in prostate cancer [51], gastric cancer [52], and oral squamous cancer cells [53]. However, the potential effect of miR-455-3p has rarely been explored in PDAC.…”

Section: Discussionmentioning

confidence: 99%

Identification of novel genes associated with a poor prognosis in pancreatic ductal adenocarcinoma via a bioinformatics analysis

et al. 2019

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Pancreatic ductal adenocarcinoma (PDAC) is a class of the commonest malignant carcinomas. The present study aimed to elucidate the potential biomarker and prognostic targets in PDAC. The array data of GSE41368, GSE43795, GSE55643, and GSE41369 were downloaded from Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) and differentially expressed microRNAs (DEmiRNAs) in PDAC were obtained by using GEO2R, and overlapped DEGs were acquired with Venn Diagrams. Functional enrichment analysis of overlapped DEGs and DEmiRNAs was conducted with Metascape and FunRich, respectively. The protein–protein interaction (PPI) network of overlapped DEGs was constructed by STRING and visualized with Cytoscape. Overall survival (OS) of DEmiRNAs and hub genes were investigated by Kaplan–Meier (KM) plotter (KM plotter). Transcriptional data and correlation analyses among hub genes were verified through GEPIA and Human Protein Atlas (HPA). Additionally, miRNA targets were searched using miRTarBase, then miRNA–DEG regulatory network was visualized with Cytoscape. A total of 32 DEmiRNAs and 150 overlapped DEGs were identified, and Metascape showed that DEGs were significantly enriched in cellular chemical homeostasis and pathways in cancer, while DEmiRNAs were mainly enriched in signal transduction and Glypican pathway. Moreover, seven hub genes with a high degree, namely, V-myc avian myelocytomatosis viral oncogene homolog (MYC), solute carrier family 2 member 1 (SLC2A1), PKM, plasminogen activator, urokinase (PLAU), peroxisome proliferator activated receptor γ (PPARG), MET proto-oncogene, receptor tyrosine kinase (MET), and integrin subunit α 3 (ITGA3), were identified and found to be up-regulated between PDAC and normal tissues. miR-135b, miR-221, miR-21, miR-27a, miR-199b-5p, miR-143, miR-196a, miR-655, miR-455-3p, miR-744 and hub genes predicted poor OS of PDAC. An integrative bioinformatics analysis identified several hub genes that may serve as potential biomarkers or targets for early diagnosis and precision target treatment of PDAC.

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“…This miRNA is frequently downregulated in colorectal tumors and acts predominantly as a tumor suppressor element by targeting phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) and Runt-related transcription factor 2 (RUNX2), both crucial for the development of tumors (72,130,131) (Figure 5). An equivalent tumor suppressor role has been attributed to miR-455 in gastric tumorigenesis (132,133).…”

Section: Mir-455mentioning

confidence: 99%

PVT1 Long Non-coding RNA in Gastrointestinal Cancer

2020

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Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosis, and differentiation; and their expression has been found dysregulated in human tumors. Thus, lncRNAs have emerged as new players in the initiation, maintenance and progression of tumorigenesis. PVT1 (plasmacytoma variant translocation 1) lncRNA is located on chromosomal 8q24.21, a large locus frequently amplified in human cancers and predictive of increased cancer risk in genome-wide association studies (GWAS). Combined, colorectal and gastric adenocarcinomas are the most frequent tumor malignancies and also the leading cause of cancer-related deaths worldwide. PVT1 expression is elevated in gastrointestinal tumors and correlates with poor patient prognosis. In this review, we discuss the mechanisms of action underlying PVT1 oncogenic role in colorectal and gastric cancer such as MYC upregulation, miRNA production, competitive endogenous RNA (ceRNA) function, protein stabilization, and epigenetic regulation. We also illustrate the potential role of PVT1 as prognostic biomarker and its relationship with resistance to current chemotherapeutic treatments.

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MiR-455-5p acts as a novel tumor suppressor in gastric cancer by down-regulating RAB18

Cited by 54 publications

References 28 publications

miR‑455‑5p promotes cell invasion and migration in breast cancer

miR‑455‑5p promotes cell invasion and migration in breast cancer

Identification of novel genes associated with a poor prognosis in pancreatic ductal adenocarcinoma via a bioinformatics analysis

PVT1 Long Non-coding RNA in Gastrointestinal Cancer

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