miR-425-5p improves inflammation and septic liver damage through negatively regulating the RIP1-mediated necroptosis

Gu, Chao; Hou, Chongzhi; Zhang, Sheng

doi:10.1007/s00011-020-01321-5

Cited by 23 publications

(23 citation statements)

References 35 publications

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“… miR-425-5p RIPK1 miR-425-5p was reported to negatively regulate the RIP1-mediated necroptosis by direct targeting the 3′UTR of RIP1 mRNA to decrease the expression of RIP1. Thus, miR-425-5p improved inflammation response and septic liver damage by inhibiting necroptosis [ 41 ]. miR-200a-5p cRIPK3 Overexpression of miR-200a-5p induced RIP3-dependent necroptosis in vivo and in vitro [ 45 ].…”

Section: Necroptosis and Cancer Metastasismentioning

confidence: 99%

“…miR-425-5p was reported to negatively regulate the RIP1-mediated necroptosis by direct targeting the 3′UTR of RIP1 mRNA to decrease the expression of RIP1. Thus, miR-425-5p improved inflammation response and septic liver injury by down-regulating the occurrence of necroptosis [ 41 ]. Moreover, the cellular mechanism Parkinson’s disease was related to necroptosis promotion by miR-425 deficiency, for miR-425 targeted RIPK1 transcripts and promoted the MLKL phosphorylation [ 42 ].…”

Section: Necroptosis and Cancer Metastasismentioning

confidence: 99%

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Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis

et al. 2021

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Distant metastasis is the main cause of death for cancer patients. Recently, the newly discovered programmed cell death includes necroptosis, pyroptosis, and ferroptosis, which possesses an important role in the process of tumor metastasis. At the same time, it is widely reported that non-coding RNA precisely regulates programmed death and tumor metastasis. In the present review, we summarize the function and role of necroptosis, pyrolysis, and ferroptosis involving in cancer metastasis, as well as the regulatory factors, including non-coding RNAs, of necroptosis, pyroptosis, and ferroptosis in the process of tumor metastasis.

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Section: Necroptosis and Cancer Metastasismentioning

confidence: 99%

Section: Necroptosis and Cancer Metastasismentioning

confidence: 99%

Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis

et al. 2021

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“…Thus, AN may produce some special inducing enzymes under the induction of the gossypol. Given that the premise of the basic physiological metabolism of the cell is guaranteed, when exogenous stimuli interfere with the normal metabolism of cells or cause cell damage, certain proteins (such as cytokines and inducible enzymes) are secreted abundantly by the cells, which are under the exogenous stimulus stress against exogenous substances and protect cells [22,23]. Therefore, when screening for a toxindegrading strain by using a medium with the toxin as the sole carbon (or nitrogen) and energy sources, the function of inducing enzymes may be overlooked by usual screening methods of the predecessors.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the toxin-degrading strain screening strategy: Deficiency and improvement in screening the gossypol-degrading microorganism Aspergillus niger

Zhang

Shu

Wang

et al. 2021

Preprint

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Background The gossypol, as an antinutritional factor or natural plant toxin, has antifertility effects on humans and animals, exists in cottonseed oil and meal, and is a typical food or feed contaminant. It is the classic screening method to using acetate gossypol as the sole carbon sources to prepare selective medium and screening gossypol-degrading microorganisms. By the classic screening strategy, many researchers have discovered that some microorganisms, and Aspergillus niger is the most reported microorganism. A strain of A. niger which can grow in an agar solid medium with gossypol as the sole carbon source is isolated from cattle rumen liquid was obtained by classic screening strategy. The effectiveness of the classic screening strategy was verified, by duplicating and verifying the degradation of gossypol by the A. niger. Results the A. niger can reduce the free gossypol (FG) content through biosorption but has no effect on the total gossypol (TG) content. And it can secrete agarase, utilise agar as carbon source. Conclusions The A. niger can secrete agarase, but cannot effectively degrade gossypol, In this case, it will mislead researchers and lead them to make wrong judgments. The usual methods of previous screening strategies are not rigorous enough, the classic screening method has defect in screening toxin-degrading strain, so agar control group should be added.

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“…[350] In a separate study, reducing necroptosis using the upstream effector miR-425-5p mitigated serum levels of pro-inflammatory cytokines (i.e., IL-1 and TNF-) as well as significantly alleviated liver injury in an LPS-induced murine sepsis model. [351] Additionally, the functions that EVs are able to provoke within their target cells generally depends on their cell of origin, [352,353] emphasizing the potential importance of differentiating iPSCs prior to use as an EV source. Compared with their tissue derived equivalents, EVs from differentiated iPSCs can display augmented therapeutic effects.…”

Section: Pluripotent Stem Cellsmentioning

confidence: 99%

“…[ 350 ] In a separate study, reducing necroptosis using the upstream effector miR‐425‐5p mitigated serum levels of pro‐inflammatory cytokines (i.e., IL‐1β and TNF‐α) as well as significantly alleviated liver injury in an LPS‐induced murine sepsis model. [ 351 ]…”

Section: Lessons Learned and Future Opportunitiesmentioning

confidence: 99%

Therapeutic Potential of Extracellular Vesicles for Sepsis Treatment

Kronstadt

Pottash

Levy

et al. 2021

Advanced Therapeutics

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Sepsis is a deadly condition lacking a specific treatment despite decades of research. This has prompted the exploration of new approaches, with extracellular vesicles (EVs) emerging as a focal area. EVs are nanosized, cell-derived particles that transport bioactive components (i.e., proteins, DNA, and RNA) between cells, enabling both normal physiological functions and disease progression depending on context. In particular, EVs have been identified as critical mediators of sepsis pathophysiology. However, EVs are also thought to constitute the biologically active component of cell-based therapies and have demonstrated anti-inflammatory, anti-apoptotic, and immunomodulatory effects in sepsis models. The dual nature of EVs in sepsis is explored here, discussing their endogenous roles and highlighting their therapeutic properties and potential. Related to the latter component, prior studies involving EVs from mesenchymal stem/stromal cells (MSCs) and other sources are discussed and emerging producer cells that could play important roles in future EV-based sepsis therapies are identified. Further, how methodologies could impact therapeutic development toward sepsis treatment to enhance and control EV potency is described.

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miR-425-5p improves inflammation and septic liver damage through negatively regulating the RIP1-mediated necroptosis

Cited by 23 publications

References 35 publications

Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis

Non-coding RNAs in necroptosis, pyroptosis and ferroptosis in cancer metastasis

Effectiveness of the toxin-degrading strain screening strategy: Deficiency and improvement in screening the gossypol-degrading microorganism Aspergillus niger

Therapeutic Potential of Extracellular Vesicles for Sepsis Treatment

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