MiR-34a/Sirt1/p53 signaling pathway contributes to cadmium-induced nephrotoxicity: A preclinical study in mice

Hao, Rili; Song, Xubin; Sun‐Waterhouse, Dongxiao; Tan, Xiao Di; Li, Feng

doi:10.1016/j.envpol.2021.117029

Cited by 22 publications

(19 citation statements)

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“…Prolonged exposure to Cd will produce adverse health effects due to its accumulation [ 3 ]. Cd accumulation in the body can lead to multiple organ damages and health diseases, including cancers [ 4 , 5 ]. Most accumulated Cd is initially absorbed in the gut before being transported to other organs [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Oleic Acid Facilitates Cd Excretion by Increasing the Abundance of Burkholderia in Cd-Exposed Mice

Fang

Chen

et al. 2022

IJMS

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As a global pollutant, cadmium (Cd) can easily enter the body through food chains, threatening human health. Most Cd is initially absorbed in the gut, with the gut microbiota playing a pivotal role in reducing Cd absorption and accumulation. This study assessed the effects of three fatty acids on Cd accumulation and toxicity in Cd-exposed mice. The results showed that oleic acid (OA) was the most effective in facilitating Cd excretion in mice among these fatty acids. The use of OA led to reduced Cd accumulation in the organs and increased Cd content in the feces. The metagenomic analysis of the gut microbiota showed that the genus Burkholderia was the most significantly restored by OA in Cd-exposed mice. Burkholderia cepacia, as the type species for the genus Burkholderia, also exhibited strong Cd tolerance after treatment with OA. Furthermore, the electron microscopy analysis showed that most of the Cd was adsorbed on the surface of B. cepacia, where the extracellular polymeric substances (EPSs) secreted by B. cepacia play a key role, displaying a strong capacity for Cd adsorption. The peak at 2355 cm−1 and the total sulfhydryl group content of EPSs showed significant increases following co-treatment with Cd and OA. The results demonstrated the potential roles that gut Burkholderia may play in OA-mediated Cd excretion in mice.

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Section: Introductionmentioning

confidence: 99%

Oleic Acid Facilitates Cd Excretion by Increasing the Abundance of Burkholderia in Cd-Exposed Mice

Fang

Chen

et al. 2022

IJMS

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“…Cadmium (Cd) is an environmental and industrial pollutant that has adverse effects in humans. 1 With industrial development, Cd is used in the manufacturing of batteries, electroplating, pigments and alloys. 2 The presence of Cd has been associated with cancer, diabetes, intestinal disease, cardiovascular disease and neurologic disease.…”

Section: Introductionmentioning

confidence: 99%

Rice hull insoluble dietary fiber alleviated experimental colitis induced by low dose of dextran sulfate sodium in cadmium-exposed mice

et al. 2022

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“…Indeed, cadmium exposure has been tightly associated with renal dysfunction and kidney damage, causing polyuria and proteinuria [ 23 , 24 ]. The proximal tubule is the major site of cadmium deposition, accumulation, and damage because of the development of proximal tubular epithelial cell hypertrophy with occurrence of polyuria and proteinuria [ 44 , 45 , 46 ]. Therefore, it is important to counteract cadmium-induced kidney injury to safeguard kidney function.…”

Section: Introductionmentioning

confidence: 99%

Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism

Allen

2021

Biomolecules

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Cadmium is a nonessential metal that has heavily polluted the environment due to human activities. It can be absorbed into the human body via the gastrointestinal tract, respiratory tract, and the skin, and can cause chronic damage to the kidneys. The main site where cadmium accumulates and causes damage within the nephrons is the proximal tubule. This accumulation can induce dysfunction of the mitochondrial electron transport chain, leading to electron leakage and production of reactive oxygen species (ROS). Cadmium may also impair the function of NADPH oxidase, resulting in another source of ROS. These ROS together can cause oxidative damage to DNA, proteins, and lipids, triggering epithelial cell death and a decline in kidney function. In this article, we also reviewed evidence that the antioxidant power of plant extracts, herbal medicines, and pharmacological agents could ameliorate cadmium-induced kidney injury. Finally, a model of cadmium-induced kidney injury, centering on the notion that oxidative damage is a unifying mechanism of cadmium renal toxicity, is also presented. Given that cadmium exposure is inevitable, further studies using animal models are warranted for a detailed understanding of the mechanism underlying cadmium induced ROS production, and for the identification of more therapeutic targets.

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MiR-34a/Sirt1/p53 signaling pathway contributes to cadmium-induced nephrotoxicity: A preclinical study in mice

Cited by 22 publications

References 50 publications

Oleic Acid Facilitates Cd Excretion by Increasing the Abundance of Burkholderia in Cd-Exposed Mice

Oleic Acid Facilitates Cd Excretion by Increasing the Abundance of Burkholderia in Cd-Exposed Mice

Rice hull insoluble dietary fiber alleviated experimental colitis induced by low dose of dextran sulfate sodium in cadmium-exposed mice

Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism

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