miR-324-3p and miR-508-5p expression levels could serve as potential diagnostic and multidrug-resistant biomarkers in childhood acute lymphoblastic leukemia

Zamani, Atefeh; Dolatabadi, Nasrin Fattahi; Houshmand, Massoud; Nabavizadeh, Nasrinsadat

doi:10.1016/j.leukres.2021.106643

Cited by 14 publications

(8 citation statements)

References 41 publications

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“…For instance, miRNA-328 and miRNA-200 are suggested as two novel biomarkers for diagnosis and prognosis, as well as miRNA-324-3p, miRNA-508-5p and miRNA-128 as potential diagnostic biomarkers of childhood ALL. [ 21 , 22 , 23 ]. Among other biomarkers related to leukemia, human leukemic lymphoblasts (CCRF-CEM) are cellular biomarkers that can be detected in the peripheral blood of children with acute leukemia [ 24 ].…”

Section: Potential Biomarkers For Childhood Cancersmentioning

confidence: 99%

Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics

Gharehzadehshirazi

Zarejousheghani

Falahi

et al. 2023

Sensors

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Although tremendous progress has been made in treating childhood cancer, it is still one of the leading causes of death in children worldwide. Because cancer symptoms overlap with those of other diseases, it is difficult to predict a tumor early enough, which causes cancers in children to be more aggressive and progress more rapidly than in adults. Therefore, early and accurate detection methods are urgently needed to effectively treat children with cancer therapy. Identification and detection of cancer biomarkers serve as non-invasive tools for early cancer screening, prevention, and treatment. Biosensors have emerged as a potential technology for rapid, sensitive, and cost-effective biomarker detection and monitoring. In this review, we provide an overview of important biomarkers for several common childhood cancers. Accordingly, we have enumerated the developed biosensors for early detection of pediatric cancer or related biomarkers. This review offers a restructured platform for ongoing research in pediatric cancer diagnostics that can contribute to the development of rapid biosensing techniques for early-stage diagnosis, monitoring, and treatment of children with cancer and reduce the mortality rate.

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Section: Potential Biomarkers For Childhood Cancersmentioning

confidence: 99%

Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics

Gharehzadehshirazi

Zarejousheghani

Falahi

et al. 2023

Sensors

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“…Down-regulation of miR-326 was introduced as a biomarker for drug resistance in childhood ALL, showing inverse correlation with the expression level of ABCA2 transporter [ 101 ]. A negative correlation was also identified between the expression of two miRNAs (miR-324-3p and miR-508-5p) and ABCA3 transporter, that is associated directly with chemoresistance [ 157 ].…”

Section: Clinical Applications Of Mirnas Focusing On Hematological Ma...mentioning

confidence: 99%

Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation

Gaál

2022

IJMS

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MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs, that are involved in the multistep process of carcinogenesis, contributing to all established hallmarks of cancer. In this review, implications of miRNAs in hematological malignancies and their clinical utilization fields are discussed. As components of the complex regulatory network of gene expression, influenced by the tissue microenvironment and epigenetic modifiers, miRNAs are “micromanagers” of all physiological processes including the regulation of hematopoiesis and metabolic pathways. Dysregulated miRNA expression levels contribute to both the initiation and progression of acute leukemias, the metabolic reprogramming of malignantly transformed hematopoietic precursors, and to the development of chemoresistance. Since they are highly stable and can be easily quantified in body fluids and tissue specimens, miRNAs are promising biomarkers for the early detection of hematological malignancies. Besides novel opportunities for differential diagnosis, miRNAs can contribute to advanced chemoresistance prediction and prognostic stratification of acute leukemias. Synthetic oligonucleotides and delivery vehicles aim the therapeutic modulation of miRNA expression levels. However, major challenges such as efficient delivery to specific locations, differences of miRNA expression patterns between pediatric and adult hematological malignancies, and potential side effects of miRNA-based therapies should be considered.

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“…However, in adults there is a recurrence rate of more than 50% and an overall survival rate of 20-40%. Resistance to chemotherapy is a major obstacle for the treatment of relapsing ALL, and there is, therefore, an urgent need to develop new therapeutic modalities [31,32].…”

Section: Acute Lymphoblastic Leukemiamentioning

confidence: 99%

“…Resistance mechanisms in ALL involve miR-324-3p and miR-508-5p which regulate ABCA3 gene expression. This gene encodes the ABC transporter, resulting in drug efflux from the tumor cells of pediatric ALL patients [32].…”

Section: Reduction Of the Concentration Of Anticancer Drugsmentioning

confidence: 99%

Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

et al. 2022

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Extracellular vesicles (EVs), including exosomes, have an important role thanks to their ability to communicate and exchange information between tumor cells and the tumor microenvironment (TME), and have also been associated with communicating anti-cancer drug resistance (DR). The increase in proliferation of cancer cells alters oxygen levels, which causes hypoxia and results in a release of exosomes by the cancer cells. In this review, the results of studies examining the role of exosomal miRNA in DR, and their mechanism, are discussed in detail in hematological tumors: leukemia, lymphoma, and multiple myeloma. In conclusion, we underline the exosome’s function as a possible drug delivery vehicle by understanding its cargo. Engineered exosomes can be used to be more specific for personalized therapy.

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miR-324-3p and miR-508-5p expression levels could serve as potential diagnostic and multidrug-resistant biomarkers in childhood acute lymphoblastic leukemia

Cited by 14 publications

References 41 publications

Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics

Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics

Implication of microRNAs in Carcinogenesis with Emphasis on Hematological Malignancies and Clinical Translation

Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

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