miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis

Fulci, Valerio; Scappucci, Gina; Giannitti, Chiara; Franceschini, Debora; Meloni, Francesca; Colombo, Teresa; Citarella, Franca; Barnaba, Vincenzo; Minisola, Giovanni; Gargiulo, Mauro; Macino, Giuseppe

doi:10.1016/j.humimm.2009.11.008

Cited by 206 publications

(144 citation statements)

References 26 publications

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“…miR-223 is involved in many types of cancer, inflammatory diseases, autoimmune diseases, and in pathological processes such as leukemia, RA, and cardiovascular disease (19)(20)(21)(22)(23). miR-223 is overexpressed in the T-lymphocytes of persons with RA, is involved in obesity-associated adipose tissue inflammation, and is a key factor in osteoclast differentiation (19,21,23). Platelet-secreted miR-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting of the insulin-like growth factor 1 receptor (24).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients

et al. 2014

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Periodontitis is a chronic inflammatory disease caused by specific bacteria and viruses. Local, systemic, and environmental factors affect the rate of disease progression. Immune responses to bacterial products, and the subsequent production of inflammatory cytokines, are crucial in the destruction of periodontal tissue. MicroRNAs (miRNAs) are a class of small RNAs that control various cell processes by negatively regulating protein-coding genes. In this study, we compared miRNA expression in inflamed and noninflamed gingival tissues from Japanese dental patients. Total RNAs were isolated from inflamed and noninflamed gingival tissues. miRNA expression profiles were examined by an miRNA microarray, and the data were analyzed by GeneSpring GX, Ingenuity Pathways Analysis, and the TargetScan databases. Observed miRNA expression levels in inflamed gingiva were confirmed by real-time PCR. The three most overexpressed (by >2.72-fold) miRNAs were hsa-miR-150, hsa-miR-223, and hsa-miR-200b, and the three most underexpressed (by <0.39-fold) miRNAs were hsa-miR-379, hsa-miR-199a-5p, and hsa-miR-214. In IPA analysis, hsa-miR-150, hsa-miR-223, and hsa-miR-200b were associated with inflammatory disease, organismal injury, abnormalities, urological disease, and cancer.

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Section: Discussionmentioning

confidence: 99%

MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients

et al. 2014

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“…Two miRNAs: miR-146 and miR-203 are associated with psoriasis and have specific pattern of expression in patients (Sonkoly et al, 2007;Nestle et al, 2009). Rheumatoid arthritis (RA) characterized by chronic inflammation of synovial tissue was also reported by various studies to be associated with miR-155, miR-146, miR-132, miR16, miR-346 and miR-223 expression change compared with healthy people (Alsaleh et al, 2009;Pauley et al, 2009;Fulci et al, 2010). Sixteen differently expressed miRNAs also were reported to be implicated in another autoimmune disorder, lupus erythematosus (SLE).…”

Section: Mirnas and Autoimmune Diseasesmentioning

confidence: 99%

MiRNA Molecular Profiles in Human Medical Conditions: Connecting Lung Cancer and Lung Development Phenomena

Aghanoori¹,

Mirzaei²,

Tavallaei³

2014

Asian Pacific Journal of Cancer Prevention

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MiRNAs are endogenous, single stranded ~22-nucleotide non-coding RNAs (ncRNAs) which are transcribed by RNA polymerase II and mediate negative post-transcriptional gene regulation through binding to 3'untranslated regions (UTR), possibly open reading frames (ORFs) or 5'UTRs of target mRNAs. MiRNAs are involved in the normal physiology of eukaryotic cells, so dysregulation may be associated with diseases like cancer, and neurodegenerative, heart and other disorders. Among all cancers, lung cancer, with high incidence and mortality worldwide, is classified into two main groups: non-small cell lung cancer and small cell lung cancer. Recent promising studies suggest that gene expression profiles and miRNA signatures could be a useful step in a noninvasive, low-cost and repeatable screening process of lung cancer. Similarly, every stage of lung development during fetal life is associated with specific miRNAs. Since lung development and lung cancer phenomena share the same physiological, biological and molecular processes like cell proliferation, development and shared mRNA or expression regulation pathways, and according to data adopted from various studies, they may have partially shared miRNA signature. Thus, focusing on lung cancer in relation to lung development in miRNA studies might provide clues for lung cancer diagnosis and prognosis.

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“…In culture, RA fibroblast like synoviocytes (FLS) proliferate and secrete a variety of cytokines/ chemokines/angiogenic factors, including fibroblast growth factor, granulocytemacrophage colony stimulating factor, interleukin 6 (IL-6), IL-8, monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory proteins 1 , and they present various adhesion molecules on their surfaces. Since the first report by Stanczyk et al in 2008, several reports have described the altered miRNAs in the joint and/or peripheral blood leucocytes of patients with RA, including miR-155, miR-146 and others (Table 1) ( Stanczyk, et al, 2008;Nakasa, et al, 2008;Pauley, et al, 2008;Murata, et al, 2010;Li, et al, 2010;Fulci, et al, 2010;Nakamachi, et al, 2009. Niimoto, et al, 2010.…”

Section: Mirna and Rheumatoid Arthritismentioning

confidence: 99%

The Role of miRNA in Rheumatoid Arthritis

Nakamachi¹

2012

Rheumatoid Arthritis - Etiology, Consequences and Co-Morbidities

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miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis

Cited by 206 publications

References 26 publications

MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients

MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients

MiRNA Molecular Profiles in Human Medical Conditions: Connecting Lung Cancer and Lung Development Phenomena

The Role of miRNA in Rheumatoid Arthritis

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