The Role of miRNA in Rheumatoid Arthritis

Nakamachi, Yuji

doi:10.5772/27061

Cited by 1 publication

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two studies have reported associations between suppression of microRNAs and RA pathogenesis: miR-363 and miR-498 were downregulated in CD4 + T-cells [ 44 ], and miR-124a in synovial fibroblasts [ 43 ]. Other miRNAs ( Table 3 ) that play significant roles in RA pathogenesis [ 45 ] include miR-223, miR-203, miR-363, and miR-498. The major epigenetic forces that are operative in RA are DNA hypomethylation and histone hyperacetylation.…”

Section: Micrornas In Rheumatoid Arthritismentioning

confidence: 99%

Rheumatoid Arthritis: The Stride from Research to Clinical Practice

Chung

Ketharnathan

Thiruvengadam

et al. 2016

IJMS

View full text Add to dashboard Cite

Over 70 different genetic variants with a significant association with rheumatoid arthritis (RA) have been discovered. Anti-citrullination protein antibodies (ACPA)-positive RA variants are more well-defined than their ACPA-negative counterparts. The human leukocyte antigen, HLA-DRB1 locus remains the prime suspect in anti-citrullination protein antibodies (ACPA)—positive RA. Different HLA-DRB1 alleles are linked to RA susceptibility across different ethnicities. With evolving techniques, like genome-wide association studies (GWAS) and single nucleotide polymorphism (SNP) arrays, more non-HLA susceptibility loci have been identified for both types of RA. However, the functional significance of only a handful of these variants is known. Their roles include increasing susceptibility to RA or in determining the speed at which the disease progresses. Additionally, a couple of variations are associated with protection from RA. Defining such clear-cut biological functions can aid in the clinical diagnosis and treatment of RA. Recent research has focused on the implication of microRNAs, with miR-146a widely studied. In addition to disease susceptibility, genetic variations that influence the efficacy and toxicity of anti-RA agents have also been identified. Polymorphisms in the MTHFR gene influence the effectiveness of methotrexate, the first line of therapy in RA. Larger studies are, however, needed to identify potential biomarkers for early disease identification and monitoring disease progression.

show abstract

Section: Micrornas In Rheumatoid Arthritismentioning

confidence: 99%