miR-218 tissue expression level is associated with aggressive progression of gastric cancer

Wang, X X; Ge, Shen; Wang, X L; Jiang, Lingyan; Sheng, Miaomiao; J, J

doi:10.4238/gmr.15027521

Cited by 8 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated that miRNAs serve important roles in human cancer biological processes, including initiation, development, migration and metastasis (22)(23)(24)(25)(26). miR-218 can act as a tumor suppressor and is downregulated in various types of human cancer (27)(28)(29)(30)(31). miR-218 can inhibit cancer cell proliferation, invasion, migration, EMT, lymph node metastasis and self-renewal in glioma, cervical cancer, gastric cancer and bladder cancer, among others (32)(33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells

Guan

Zhang

et al. 2018

Oncol Lett

View full text Add to dashboard Cite

MicroRNA (miRNA) is a class of non-coding single-stranded RNA, able to regulate tumor-associated genes via binding the 3'-UTR of the target gene mRNA. Previous publications have demonstrated that miRNA-218 (miR-218) acts as a tumor-suppressive miRNA in various types of human cancer, including prostate cancer (PCa). However, the role of miR-218 in regulating PCa cell stemness and epithelial-mesenchymal transition remains unknown and requires further research. In the present study, it is demonstrated that miR-218 was downregulated in 2 PCa cell lines and could suppress cell migration, EMT and the exhibition of cancer stem cell-like properties. The expression of GLI family zinc finger 1 (Gli1) was inhibited by miR-218 overexpression, suggesting miR-218-suppression of Gli1 as a potential mechanism for the tumor-suppressive effect of miR-218. Overall, the results indicate that miR-218 served a critical role in the inhibition of PCa development. This may provide new insight for elucidating the mechanisms of PCa oncogenesis and suggests that miR-218 may be a novel therapeutic target for PCa.

show abstract

Section: Discussionmentioning

confidence: 99%

MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells

Guan

Zhang

et al. 2018

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…In addition to this, we evaluated the expression levels of miR-218 among 359 GC patients in the TCGA dataset and observed that higher miR-218 expression level was associated with a better survival of GC ( P = 0.002). Recent research also confirmed that lower miR-218 tissue expression level was associated with aggressive progression of gastric cancer [30]. Meanwhile, miR-218 could inhibit invasion and metastasis of gastric cancer by targeting the Robo1 receptor [31].…”

Section: Discussionmentioning

confidence: 98%

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Jia

Cao

et al. 2017

Disease Markers

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93, P = 0.009) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95, P = 0.016). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.

show abstract

“…[43] MIR-331 and MIR-218 have been found to regulate the development and progression of various types of cancer cells. [44][45][46][47] Interestingly, the role of the transcription factor target IRF family in the regulation of cell cycle and apoptosis as well as its important function in immune response, immune cell development, and the regulation of tumorigenesis has been emphasized,. [48,49] Thus, TLR1/2/7/8 may regulate cell cycle, apoptosis and immune response in LUAD via these transcription factor targets, kinase targets and miRNA targets.…”

Section: Discussionmentioning

confidence: 99%

Identification of TLRs as potential prognostic biomarkers for lung adenocarcinoma

Ying,

Hong,

et al. 2023

Medicine

View full text Add to dashboard Cite

Lung adenocarcinoma (LUAD) is one of the most common tumors with the highest cancer-related death rate worldwide. Early diagnosis of LUAD can improve survival. Abnormal expression of the Toll-like receptors (TLRs) is related to tumorigenesis and development, inflammation and immune infiltration. However, the role of TLRs as an immunotherapy target and prognostic marker in lung adenocarcinoma is not well understood and needs to be analyzed. Relevant data obtained from databases such as ONCOMINE, UALCAN, GEPIA, and the Kaplan–Meier plotter, GSCALite, GeneMANIA, DAVID 6.8, Metascape, LinkedOmics and TIMER, to compare transcriptional TLRs and survival data of patients with LUAD. The expression levels of TLR1/2/3/4/5/7/8 in LUAD tissues were significantly reduced while the expression levels of TLR6/9/10 were significantly elevated. LUAD patients having low expression of TLR1/2/3/5/8 and high expression of TLR9 had a poor overall survival while patients with low expression of TLR2/3/7 presented with worse first progress. TLR4, TLR7 and TLR8 are the 3 most frequently mutated genes in the TLR family. Correlation suggested a low to moderate correlation among TLR family. TLR family was also involved in the activation or inhibition of the famous cancer related pathways. Analysis of immune infiltrates analysis suggested that TLR1/2/7/8 levels significantly correlated with immune infiltration level. Enrichment analysis revealed that TLRs were involved in TLR signaling pathway, immune response, inflammatory response, primary immunodeficiency, regulation of IL-8 production and PI3K-Akt signaling pathway. Our results provided information on TLRs expression and potential regulatory networks in LUAD. Moreover, our results suggested TLR2/7/8 as a potential prognostic biomarker for lung adenocarcinoma.

show abstract

miR-218 tissue expression level is associated with aggressive progression of gastric cancer

Cited by 8 publications

References 18 publications

MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells

MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells

Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

Identification of TLRs as potential prognostic biomarkers for lung adenocarcinoma

Contact Info

Product

Resources

About