2015
DOI: 10.1016/j.yexcr.2015.07.023
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miR-218 is involved in the negative regulation of osteoclastogenesis and bone resorption by partial suppression of p38MAPK-c-Fos-NFATc1 signaling: Potential role for osteopenic diseases

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Cited by 31 publications
(28 citation statements)
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“…While miR-7b was down-regulated during osteoclastogenesis in RAW264.7 cells stimulated by M-CSF and RANKL, and overexpression of miR-7b decreased TRAP-positive MNCs in number, inhibition of miR-7b promoted osteoclastogenesis [28]. Besides, Qu et al [29] manifested that miR-218-5p acted as a negative regulator of osteoclastogenesis by targeting the p38MAPK-c-Fos-NFATc1 pathway. Chen et al [30] also presented that miR-503 inhibited osteoclast differentiation by suppressing RANK, which was a target of miR-503.…”
Section: Discussionmentioning
confidence: 99%
“…While miR-7b was down-regulated during osteoclastogenesis in RAW264.7 cells stimulated by M-CSF and RANKL, and overexpression of miR-7b decreased TRAP-positive MNCs in number, inhibition of miR-7b promoted osteoclastogenesis [28]. Besides, Qu et al [29] manifested that miR-218-5p acted as a negative regulator of osteoclastogenesis by targeting the p38MAPK-c-Fos-NFATc1 pathway. Chen et al [30] also presented that miR-503 inhibited osteoclast differentiation by suppressing RANK, which was a target of miR-503.…”
Section: Discussionmentioning
confidence: 99%
“…Osteoclasts play a vital role in the periodontitis pathological bone loss and physiological bone remodelling. MiR‐218 has been reported to decrease during osteoclastogenesis induced by RANKL (Qu et al, ). We next investigated the effect of miR‐218 on osteoclastogenesis.…”
Section: Resultsmentioning
confidence: 99%
“…Kabsun Kim found that miR‐26a negatively regulates the osteoclast production induced by RANKL through repressing CTGF expression (Kim et al, ). MiR‐183 can increase RANKL‐induced osteoclastogenesis through suppressing haem oxygenase‐1 expression (Ke, Sul, Rajasekaran, & Choi, ), although miR‐218 involved in the negative regulation of osteoblast differentiation and bone resorption has been reported (Qu et al, ). This study first demonstrated that miR‐218 could attenuate the osteoclast formation by regulating Mmp9 expression.…”
Section: Discussionmentioning
confidence: 99%
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“…For example, miR-29 (Franceschetti et al, 2013), miR-31-5p (Mizoguchi et al, 2013), miR-183-5p (Ke et al, 2015), and miR-214 (Zhao et al, 2015) have been reported to be upregulated in BMMs and promote osteoclast formation. In contrast, miR-7b-5p (Dou et al, 2014), miR-34a-5p (Krzeszinski et al, 2014), miR-124-3p (Lee et al, 2013), and miR-218-5p (Qu et al, 2015) were downregulated in BMMs and inhibited osteoclast formation. However, the relationship between the expression pattern of miRNA and its role in osteoclastogenesis is complex.…”
Section: Discussionmentioning
confidence: 99%