miR‐210: The Master Hypoxamir

Abstract

MicroRNAs (miRs) are small non-coding RNAs implicated mainly in post-transcriptional gene silencing by interacting with the unstranslated region of the transcript. miR-210 represents a major hypoxia-inducible miRs, also known as hypoxamirs, which is ubiquitously expressed in a wide range of cells, serving versatile functions. This review article summarizes the current progress on biogenesis of miR-210 and its physiological roles including arrest of cell proliferation, repression of mitochondrial respiration, arrest of DNA repair, vascular biology, and angiogenesis. Given the fact that miR-210 is aberrantly expressed in a number of diseases such as tumor progression, myocardial infarction and cutaneous ischemic wounds, miR-210 could serve as an excellent candidate for prognostic purposes and therapeutic intervention. With the advancement of computational prediction, high-throughput target validation methodology, sequencing, proteomic analysis and microarray, it is anticipated that more down-stream targets of miR-210 and its-associated biological consequences under hypoxia will be unveiled establishing miR-210 as a major hub in the biology of hypoxia-response.

MicroRNA Expression Profiling of Sputum for the Detection of Early and Locally Advanced Non-Small-Cell Lung Cancer: A Prospective Case–Control Study

“…Overexpression of mir-210 has also been demonstrated in lung, esophageal, and pancreatic cancer 34,35 , and this mirna is often referred to as the "master" hypoxia mirna 36 . The response to hypoxia has been well demonstrated to result in upregulation of mir-210 37,38 .…”

Neurogenetic Aspects of Perinatal Hypoxic-Ischemic Affections of the Central Nervous System

“…В 2014 г. стало известно, что гипоксия индуцирует и плацентарный фактор роста из семейства VEGF [74]. Установлены эпигенетические механизмы регуляции ангиогенеза -модификации гистона и микроРНК [74,75]. В связи с этим представ-ляет интерес эксперимент со стереотаксической инъек-цией микроРНК-210 в одно полушарие головного мозга мышей [71].…”

L’hypoxie tumorale

“…L'hypoxie est capable de réguler l'expression de plusieurs miR [17]. Elle diminue, par exemple, l'expression de miR anti-oncogéniques, tels que miR-101, et augmente l'expression de miR pro-oncogéniques, tels que miR-21 et miR-210 [15,16]. Plusieurs arguments soulignent que miR-210 est l'un des principaux miR induits par hypoxie [16].…”

“…Elle diminue, par exemple, l'expression de miR anti-oncogéniques, tels que miR-101, et augmente l'expression de miR pro-oncogéniques, tels que miR-21 et miR-210 [15,16]. Plusieurs arguments soulignent que miR-210 est l'un des principaux miR induits par hypoxie [16]. Ce miR a été récemment impliqué dans la résistance tumorale à la lyse par les lymphocytes T cytotoxiques, via une régulation de l'expression des gènes PTPN1 (protein tyrosine phosphatase, non-receptor type 1), HOXA1 (homeobox A1), et TP53I11 [3,4].…”