MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C

Liao, Ming; Peng, Lijun

doi:10.1186/s11658-020-00216-x

Cited by 44 publications

(35 citation statements)

References 32 publications

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“…The silencing also suppressed the tumor growth in vivo . As a target of several microRNAs, CORO1C promotes cell proliferation, invasion, and migration in non-small lung cancer, hepatocellular carcinoma, and triple-negative breast cancer ( Wang et al, 2014 ; Han et al, 2020 ; Liao and Peng, 2020 ). It was demonstrated that knockdown of CORO1C dramatically suppressed cell viability, colony formation, mitosis, and metastasis and promotes apoptosis of gastric cancer cells ( Cheng et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

Wang¹,

Jia

Sun

et al. 2021

Front. Mol. Biosci.

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Trophoblast cell surface protein 2 (Trop2) is one of the cancer-related proteins that plays a vital role in biological aggressiveness and poor prognosis of colorectal cancer (CRC). The study of the Trop2 related network is helpful for us to understand the mechanism of tumorigenesis. However, the effects of the related proteins interacting with Trop2 in CRC remain unclear. Here, we found that coronin-like actin-binding protein 1C (CORO1C) could interact with Trop2 and the expression of CORO1C in CRC tissues was higher than that in paracarcinoma tissues. The expression of CORO1C was associated with histological type, lymph node metastasis, distant metastasis, AJCC stage, venous invasion, and perineural invasion. The correlation between CORO1C expression and clinical characteristics was analyzed demonstrating that high CORO1C expression in CRC patients were associated with poor prognosis. Furthermore, CORO1C knockdown could decrease the cell proliferation, colony formation, migration and invasion in vitro and tumor growth in vivo. The underlying mechanisms were predicted by bioinformatics analysis and verified by Western blotting. We found that PI3K/AKT signaling pathway was significantly inhibited by CORO1C knockdown and the tuomr-promoting role of CORO1C was leastwise partly mediated by PI3K/AKT signaling pathway. Thus, CORO1C may be a valuable prognostic biomarker and drug target in CRC patients.

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Section: Discussionmentioning

confidence: 99%

CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

Wang¹,

Jia

Sun

et al. 2021

Front. Mol. Biosci.

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“…Gene symbol Description Associated diseases of host gene Associated diseases of circRNA hsa_circ_0000280 HPS5 Hermansky-Pudlak Syndrome 5 Hermansky-Pudlak type 5 syndrome [43] hsa_circ_0000437 CORO1C Coronin, Actin-binding protein, 1C Gastric cancer [44] Hepatocellular carcinoma [45] Lung cancer [46] Breast Cancer [47] Endometrial cancer [48] has_circ_0001085 GLS Glutaminase Prostate cancer [49] Cholangiocarcinoma [50] Non-small cell lung cancer [51] Colorectal cancer [52] Breast cancer [53] --hsa_circ_0002100 ARHGEF12 Rho guanine nucleotide exchange factor 12…”

Section: Circrnamentioning

confidence: 99%

Autophagy-related circRNA evaluation reveals hsa_circ_0001747 as a potential favorable prognostic factor for biochemical recurrence in patients with prostate cancer

Zhong

Wang

et al. 2021

Cell Death Dis

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Prostate cancer (PCa) is a common high-incidence malignancy in men, some of whom develop biochemical recurrence (BCR) in the advanced stage. However, there are currently no accurate prognostic indicators of BCR in PCa. The aim of our study was to identify an autophagy-related circular RNA prognostic factor of BCR for patients with PCa. In this study, immunochemistry revealed that the classic autophagy marker MAP1LC3B was positively correlated with Gleason score. Least absolute shrinkage and selector operator regression were conducted to develop a novel prognostic model with tenfold cross-validation and an L1 penalty. Five autophagy-related circRNA signatures were included in the prognostic model. Patients with PCa were ultimately divided into high- and low-risk groups, based on the median risk score. Patients with PCa, who had a high risk score, were more likely to develop BCR in a shorter period of time. Univariate and multivariate Cox regression analyses demonstrated that the risk score was an independent variable for predicting BCR in PCa. In addition, a prognostic nomogram integrated with the risk score and numerous clinicopathological parameters was developed to accurately predict 3- and 5-year BCR of patients with PCa. Finally, the hsa_circ_0001747 signature was selected for further experimental verification in vitro and in vivo, which showed that downregulated hsa_circ_0001747 might facilitate PCa via augmenting autophagy. Our findings indicate that the autophagy-related circRNA signature hsa_circ_0001747 may serve as a promising indicator for BCR prediction in patients with PCa.

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“…Liao et al found a decrease in the miR-206 levels in NSCLC. The oncosuppressive mechanism of miR-206 is that this microRNA inhibits the development of NSCLC metastases through the negative regulation of the actin-binding protein coronin 1C (CORO1C) [ 91 ]. CORO1C knockdown significantly reduced the ability of cells to grow and metastasize in gastric [ 92 ] and breast cancer [ 93 ].…”

Section: Asbestos As a Carcinogenic Factor Of The Environmentmentioning

confidence: 99%

Role of microRNAs in Lung Carcinogenesis Induced by Asbestos

Bersimbaev

Bulgakova

Aripova

et al. 2021

JPM

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MicroRNAs are a class of small noncoding endogenous RNAs 19–25 nucleotides long, which play an important role in the post-transcriptional regulation of gene expression by targeting mRNA targets with subsequent repression of translation. MicroRNAs are involved in the pathogenesis of numerous diseases, including cancer. Lung cancer is the leading cause of cancer death in the world. Lung cancer is usually associated with tobacco smoking. However, about 25% of lung cancer cases occur in people who have never smoked. According to the International Agency for Research on Cancer, asbestos has been classified as one of the cancerogenic factors for lung cancer. The mechanism of malignant transformation under the influence of asbestos is associated with the genotoxic effect of reactive oxygen species, which initiate the processes of DNA damage in the cell. However, epigenetic mechanisms such as changes in the microRNA expression profile may also be implicated in the pathogenesis of asbestos-induced lung cancer. Numerous studies have shown that microRNAs can serve as a biomarker of the effects of various adverse environmental factors on the human body. This review examines the role of microRNAs, the expression profile of which changes upon exposure to asbestos, in key processes of carcinogenesis, such as proliferation, cell survival, metastasis, neo-angiogenesis, and immune response avoidance.

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MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C

Cited by 44 publications

References 32 publications

CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

CORO1C is Associated With Poor Prognosis and Promotes Metastasis Through PI3K/AKT Pathway in Colorectal Cancer

Autophagy-related circRNA evaluation reveals hsa_circ_0001747 as a potential favorable prognostic factor for biochemical recurrence in patients with prostate cancer

Role of microRNAs in Lung Carcinogenesis Induced by Asbestos

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