MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke

Li, Yamei; Peng, Bo; Li, Yang; Huang, Airu; Peng, Yifei; Yu, Qian; Li, Yufeng

doi:10.1016/j.cbi.2022.109900

Cited by 19 publications

(10 citation statements)

References 34 publications

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“…This was achieved by impairing the SRC signaling trajectory, subsequently realizing gentle inhibitory effects on platelet aggregation ( 36 ). Symmetrically, SRC is seen to execute a neuroprotective role in stroke ( 37 ). In a sophisticated proteomic analysis by George PM et al., PPBP emerged as a key biomarker in transient ischemic attack (TIA) patients’ serum.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning

Geng,

Liu,

Wang

et al. 2024

Front. Immunol.

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BackgroundIschemic stroke (IS), caused by blood and oxygen deprivation due to cerebral thrombosis, has links to activated and aggregated platelets. Discovering platelet-related biomarkers, developing diagnostic models, and screening antiplatelet drugs are crucial for IS diagnosis and treatment.Methods and resultsCombining and normalizing GSE16561 and GSE22255 datasets identified 1,753 upregulated and 1,187 downregulated genes. Fifty-one genes in the platelet-related module were isolated using weighted gene co-expression network analysis (WGCNA) and other analyses, including 50 upregulated and one downregulated gene. Subsequent enrichment and network analyses resulted in 25 platelet-associated genes and six diagnostic markers for a risk assessment model. This model’s area under the ROC curve outperformed single genes, and in the peripheral blood of the high-risk group, immune infiltration indicated a higher proportion of CD4, resting CD4 memory, and activated CD4 memory T cells, along with a lower proportion of CD8 T cells in comparison to the low-risk group. Utilizing the gene expression matrix and the CMap database, we identified two potential drugs for IS. Finally, a rat MACO/R model was used to validate the diagnostic markers’ expression and the drugs’ predicted anticoagulant effects.ConclusionWe identified six IS platelet-related biomarkers (APP, THBS1, F13A1, SRC, PPBP, and VCL) for a robust diagnostic model. The drugs alpha-linolenic acid and ciprofibrate have potential antiplatelet effects in IS. This study advances early IS diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning

Geng,

Liu,

Wang

et al. 2024

Front. Immunol.

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“…See supplementary section for further details [ 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ].…”

Section: Methodsmentioning

confidence: 99%

In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation

Elebeedy

Ghanem

Saleh

et al. 2022

IJMS

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The increasing prevalence of obesity has become a demanding issue in both high-income and low-income countries. Treating obesity is challenging as the treatment options have many limitations. Recently, diet modification has been commonly applied to control or prevent obesity and its risks. In this study, we investigated novel therapeutic approaches using a combination of a potential probiotic source with prebiotics. Forty-eight adult male Sprague–Dawley rats were selected and divided into seven groups (eight rats per group). The first group was fed a high-fat diet, while the second group was a negative control. The other five groups were orally administered with a probiotic, Lactiplantibacillus plantarum (L. plantarum), and potential prebiotics sources (chia seeds, green tea, and chitosan) either individually or in combination for 45 days. We collected blood samples to analyze the biochemical parameters and dissected organs, including the liver, kidney, and pancreas, to evaluate obesity-related injuries. We observed a more significant decrease in the total body weight by combining these approaches than with individual agents. Moreover, treating the obese rats with this combination decreased serum catalase, superoxide dismutase, and liver malondialdehyde levels. A histopathological examination revealed a reduction in obesity-related injuries in the liver, kidney, and pancreas. Further docking studies indicated the potential role of chia seeds and green tea components in modulating obesity and its related problems. Therefore, we suggest that the daily administration of a pre- and probiotic combination may reduce obesity and its related problems.

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“…Most studies from various researchers have demonstrated unidirectional effectiveness regarding the neuroprotective role of miR-10b-3p [ 116 , 117 ], miR-124-3p [ 119 , 120 ], miR-141-3p [ 107 , 131 ], miR-153-3p [ 141 , 142 ], miR-182-5p [ 101 , 150 ], miR-20a-3p [ 162 , 163 ], miR-22-3p [ 171 , 172 ], miR-24-3p [ 175 , 176 ], miR-27a-3p [ 181 , 182 , 183 ], miR-342-5p [ 191 , 192 ], miR-455-3p [ 200 , 201 ], miR-488-3p [ 203 , 204 ], and miR-92b-3p [ 100 , 221 ] as well as the damaging role of miR-141-3p [ 107 , 131 ], miR-155-5p [ 111 , 112 ], and miR-182 [ 148 , 149 ]. Therefore, these specific microRNAs should be considered as priority targets for further translation into clinical practice.…”

Section: Regulation Of Signaling Pathways In Ischemia and Reperfusion...mentioning

confidence: 99%

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

Tregub,

Ibrahimli,

Averchuk

et al. 2023

IJMS

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In recent times, there has been a significant increase in researchers’ interest in the functions of microRNAs and the role of these molecules in the pathogenesis of many multifactorial diseases. This is related to the diagnostic and prognostic potential of microRNA expression levels as well as the prospects of using it in personalized targeted therapy. This review of the literature analyzes existing scientific data on the involvement of microRNAs in the molecular and cellular mechanisms underlying the development of pathologies such as Alzheimer’s disease, cerebral ischemia and reperfusion injury, and dysfunction of the blood–brain barrier.

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MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke

Cited by 19 publications

References 34 publications

Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning

Identification and validation of platelet-related diagnostic markers and potential drug screening in ischemic stroke by integrating comprehensive bioinformatics analysis and machine learning

In Vivo and In Silico Investigation of the Anti-Obesity Effects of Lactiplantibacillus plantarum Combined with Chia Seeds, Green Tea, and Chitosan in Alleviating Hyperlipidemia and Inflammation

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

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