miR-195 down-regulation is a distinctive biomarker of HER2 positive state in breast cancer

Balmeh, Negar; Tabatabaeian, Hossein; Asgari, Mostafa; Mokhtarian, Roya; Abharian, Parastoo Hassani; Azadeh, Mansoureh; Ghaedi, Kamran

doi:10.1016/j.genrep.2020.100703

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…In addition, the down-regulation of miR-195, which is shown in different cancers (66)(67)(68)(69)(70), was reported to cause thyroid tumorigenesis in vitro and in vivo via activating Wnt pathway. Through direct targeting cyclin D1 and Fibroblast Growth Factor 2 (FGF2) genes, miR-195 was shown to inhibit cell proliferation, migration, and invasion via down-regulating β-catenin, c-Myc, cyclin D1 and Matrix Metallopeptidase-13 (MMP-13) (71).…”

Section: Wnt-mediated Tumorigenic Effects Of Dysregulated Mirnasmentioning

confidence: 99%

Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

Tabatabaeian¹,

Yang²,

Tay³

2020

Preprint

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Thyroid cancer is the most prevalent malignancy of the endocrine system and the ninth most common cancer globally. Despite the advances in the management of thyroid cancer, there are critical issues with the diagnosis and treatment of thyroid cancer that result in the poor overall survival of undifferentiated and metastatic thyroid cancer patients. Recent studies have revealed the role of different non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) that are dysregulated during thyroid cancer development or the acquisition of resistance to therapeutics, and may play key roles in treatment failure and poor prognosis of the thyroid cancer patients. Here, we systematically review the emerging roles and molecular mechanisms of ncRNAs that regulate thyroid tumorigenesis and drug response. We then propose the potential clinical implications of ncRNAs as novel diagnostic and prognostic biomarkers for thyroid cancer.

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Section: Wnt-mediated Tumorigenic Effects Of Dysregulated Mirnasmentioning

confidence: 99%

Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

Tabatabaeian¹,

Yang²,

Tay³

2020

Preprint

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“…Hereditary genetic factors cause breast cancer in 25% of cases (3). Due to a plethora of knowledge on cancer etiology, several breast cancers start and progression factors have been found in the domains of somatic mutations and single nucleotide polymorphisms, as well as coding and non-coding gene expression alterations (4).…”

Section: Introductionmentioning

confidence: 99%

Up-regulation of LINC01010 and lncRNA CASC15 can regulate the p53 signaling pathway and apoptosis process by regulation of PERP expression level as a breast cancer biomarker: Integrated systems biology and experimental approach

Karimi

Khorasgani

Naghieh³

et al. 2022

Preprint

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Objectives The transmembrane protein PERP is present in numerous epithelial and epithelium-derived cells in tessellating junctions and other junctional and non-junctional plasma membrane regions. Previous research has focused on the involvement of the PERP gene and associated non-coding RNA regulators in developing several cancer types. In this study, we performed a high-throughput microarray data analysis and related interaction and pathway analysis to find novel genes in breast cancer and perform a qRT-PCR experiment to measure the accurate expression level of genes. Materials and method Microarray data analysis and gene set enrichment analysis (GSEA) were performed to find novel dysregulated genes in the breast cancer (BC) samples. Protein-protein interaction, pathway enrichment, gene ontology (GO), and RNA interaction analyses were performed to find an integrated regulation network. The qRT-PCR experiment was performed to evaluate the expression of found genes. Results According to the bioinformatics analyses, PERP, lncRNA CASC15, and LINC01010 were selected as the hub dysregulated genes in the BC samples, regulating the p53 signaling pathway. These genes were selected from a ceRNA network. PERP (logFC: 2.631, p-value: 0.006), lncRNA CASC15 (logFC: 2.627, p-value: 0.0018), and LINC01010 (logFC: 1.838, p-value: 0.0049) have up-regulation significantly in the BC samples. Also, CASC15 can be considered as a novel diagnostic biomarker of Isfahan BC (AUC: 0.7008, p-value: 0.0149). There were significant correlations between the expression of PERP and LINC01010 and age, menopausal and HER2 receptor statuses of Isfahan patients. Conclusion LINC01010 and CASC15 can regulate the expression level of PERP in the BC patients and change the normal regulation of the p53 signaling pathway and affect the apoptosis process of normal cells. CASC15 as a potential diagnostic biomarker and LINC01010 as a potential prognostic biomarker could regulate the BC development in the different ages, menopausal statuses, and HER2 receptor negative patients.

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