MiR-192-5p suppresses the growth of bladder cancer cells via targeting Yin Yang 1

Ji, Decai; Jiang, Lining; Li, Yingjie

doi:10.1007/s13577-018-0201-6

Cited by 27 publications

(27 citation statements)

References 34 publications

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“…In liver fluke‐associated cholangiocarcinoma, serum miR‐192‐5p level was also elevated and might be involved in tumor genesis, metastasis, and poor survival . For some cancers such as hepatocellular carcinoma, bladder cancer, and non‐small cell lung cancer, miR‐192‐5p could act as a promoter of tumor proliferation and metastasis by targeting semaphorin 3A, Yin Yang 1, and the PI3K/Akt pathway, respectively . Besides, the other three upregulated serum miRNAs (let‐7b‐5p, miR‐223‐3p, and miR‐25‐3p) have also been reported to be associated with various cancer types, including prostate cancer, ovarian cancer, lung cancer, multiple myeloma, and anaplastic thyroid carcinoma .…”

Section: Discussionmentioning

confidence: 99%

Identification of a six‐miRNA panel in serum benefiting pancreatic cancer diagnosis

et al. 2019

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Pancreatic cancer (PC) has posed a great health threat to a growing number of people all over the world. Detection of serum miRNAs, being sensitive, noninvasive, and easy to obtain, has a great potential of being a novel screening method for PC patients. In this study, we investigated miRNA expression levels in serum by qRT‐PCR. The study was divided into four phases: the screening, training, testing, and external validation stage. We firstly chose candidate miRNAs using Exiqon panels in the screening phase. Then, a total of 129 PC serum samples and 107 normal controls (NCs) were further analyzed in the following training and testing phases to identify differently expressed miRNAs. A cohort of 30 PC serum samples vs 30 NCs was used to confirm the diagnostic value of the identified miRNAs in the external validation phase. Moreover, miRNA expressions in additional 44 PC tumor tissue samples and the matched adjacent normal tissue samples as well as 32 pairs of serum‐derived exosomes samples were also further explored. As a result, we identified six significantly upregulated miRNAs in the serum of PC: let‐7b‐5p, miR‐192‐5p, miR‐19a‐3p, miR‐19b‐3p, miR‐223‐3p, and miR‐25‐3p. A six‐miRNA panel in serum was then established. The area under the receiver operating characteristic curves (AUC) for the panel was 0.910 for the combined training and testing phases, which showed higher diagnostic value than the individual miRNA. Prognostic value prediction using Cox's proportional hazards model and Kaplan‐Meier curves showed that increased serum miR‐19a‐3p was closely related to worse overall survival (OS). In addition, significant upregulation of miR‐192‐5p, miR‐19a‐3p, and miR‐19b‐3p was observed in both PC tissue and serum‐derived exosomes samples. In conclusion, we identified a six‐miRNA (let‐7b‐5p, miR‐192‐5p, miR‐19a‐3p, miR‐19b‐3p, miR‐223‐3p, and miR‐25‐3p) panel in the serum for PC early and noninvasive diagnosis.

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Section: Discussionmentioning

confidence: 99%

Identification of a six‐miRNA panel in serum benefiting pancreatic cancer diagnosis

et al. 2019

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“…Ectopic expression of miR-192 may be related to tumour occurrence as it exerts a significant effect on the progression of various malignancies. Recent studies have reported that miR-192 is considerably reduced in many malignant tumours and may be involved in regulating the proliferation, migration, and invasion of cancer cells in neoplasms 20,21,30,31 . For instance, Ji et al 30 suggested that miR-192-5p was significantly reduced in human bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have reported that miR-192 is considerably reduced in many malignant tumours and may be involved in regulating the proliferation, migration, and invasion of cancer cells in neoplasms 20,21,30,31 . For instance, Ji et al 30 suggested that miR-192-5p was significantly reduced in human bladder cancer. Overexpression of miR-192-5p inhibited the biological function of bladder cancer cells, while downregulation of miR-192-5p contributed to bladder cancer cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

Zou

Zhu

Lian

et al. 2019

Sci Rep

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Lung cancer is the leading cause of cancer-related deaths worldwide, with 50-70% of patients suffering from bone metastasis. Accumulating evidence has demonstrated that miRNAs are involved in cell proliferation, migration, and invasion in malignancy, such as lung cancer bone metastasis. In the present study, we demonstrated that reduced miR-192-5p and increased TRIM44 levels were associated with the proliferation, migration and invasion of lung cancer. Furthermore, the potential functions of miR-192-5p were explored in A549 and NCI-H1299 cells. We found that miR-192-5p upregulation suppressed tumour behaviours in lung cancer cells. To further investigate whether miR-192-5p is associated with TRIM44, we used TargetScan software to predict the binding site between miR-192-5p and TRIM44. Luciferase activity assays were performed to verify this prediction. In addition, the significant role of miR-192-5p in negatively regulating TRIM44 expression was manifested by our research group. our results suggest that miR-192-5p inhibited the proliferation, migration and invasion of lung cancer through TRIM44.

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“…Recently, the different effect of miR-192 has aroused our concern. It has been reported that miR-192 was downregulated in colon cancer, osteosarcoma, and bladder cancer [9][10][11]. However, upregulation of miR-192 was found in pancreatic ductal adenocarcinoma, neuroblastoma, and gastric cancer [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-192 promotes the development of nasopharyngeal carcinoma through targeting RB1 and activating PI3K/AKT pathway

Huang

Hou²,

Zhu

et al. 2020

World J Surg Onc

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Background: The dysregulation of microRNAs (miRNAs) has been found in diseases and cancers, including microRNA-192 (miR-192). This study was designed to investigate the role of miR-192 in nasopharyngeal carcinoma (NPC) progression. Methods: The expression levels of miR-192 and some genes were assessed by qRT-PCR and Western blot. The function of miR-192 was investigated through MTT, Transwell, and dual-luciferase reporter assays. Results: The expression of miR-192 was increased in NPC tissues, and high miR-192 expression predicted poor prognosis in NPC patients. Functionally, upregulation of miR-192 promoted NPC cell migration, invasion, and growth. Furthermore, miR-192 activated EMT and PI3K/AKT pathway to regulate NPC progression. In addition, miR-192 directly targeted RB1 and suppressed its expression in NPC. Moreover, overexpression of RB1 weakened the promoted effect of miR-192 in NPC. Conclusion: miR-192 promoted cell viability and metastasis in NPC through suppressing RB1 expression and activating PI3K/AKT pathway.

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MiR-192-5p suppresses the growth of bladder cancer cells via targeting Yin Yang 1

Cited by 27 publications

References 34 publications

Identification of a six‐miRNA panel in serum benefiting pancreatic cancer diagnosis

Identification of a six‐miRNA panel in serum benefiting pancreatic cancer diagnosis

miR-192-5p suppresses the progression of lung cancer bone metastasis by targeting TRIM44

MicroRNA-192 promotes the development of nasopharyngeal carcinoma through targeting RB1 and activating PI3K/AKT pathway

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