miR-1908 Dysregulation in Human Cancers

Shen, Jinze; Wu, Yuchen; Ruan, Wenjie; Zhu, Feng; Duan, Shiwei

doi:10.3389/fonc.2022.857743

Cited by 12 publications

(12 citation statements)

References 77 publications

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“…Previous studies have shown that miR-1294 is downregulated in 15 cancers, suggesting that elevated expression of miR-1294 may have anticancer potential. CeRNAs can compete with miRNAs to regulate the expression of protein-coding genes at the post-transcriptional level [5,6]. The ceRNAs of miR-1294 are highly expressed in 11 tumors, and by inhibiting the expression of miR-1294, they promote the occurrence and development of cancer (Tables 1 and 2).…”

Section: Dysregulated Mir-1294 In Cancermentioning

confidence: 99%

The tumor suppressor role and ceRNA network of miR-1294 in cancer

Mao¹,

Shen²,

FANG³

et al. 2023

Oncology Research

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miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation, migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR, RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC, PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and provides a basis for the clinical significance of the tumor suppressor miR-1294 in cancer.

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Section: Dysregulated Mir-1294 In Cancermentioning

confidence: 99%

The tumor suppressor role and ceRNA network of miR-1294 in cancer

Mao¹,

Shen²,

FANG³

et al. 2023

Oncology Research

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“…Repression of protein-coding genes by miRNAs can also modulate various cancer cell behaviors [43]. As shown in Fig.…”

Section: The Effect Of Mir-637 On Cell Behaviorsmentioning

confidence: 99%

“…Oncogenic signaling pathways can enhance the metabolic level of cancer cells to meet the energy requirements for cancer cell growth [44]. miRNAs can affect the metabolism of cancer cells by inhibiting the AMPK signaling pathway [43]. For example, miR-3619-5p can inhibit fatty acid oxidation in cancer cells for energy [45].…”

Section: The Inhibitory Effect Of Mir-637 On Cancer Cell Growthmentioning

confidence: 99%

Dysfunction and ceRNA network of the tumor suppressor miR-637 in cancer development and prognosis

Shen

Liang

et al. 2022

Biomark Res

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MicroRNAs (miRNAs) are a class of small non-coding RNAs ranging from 17 to 25 nt in length. miR-637 is down-regulated in most cancers and up-regulated only in clear cell renal cell carcinoma (ccRCC). miR-637 can target 21 protein-coding genes, which are involved in the regulation of cell growth, cell cycle, cell proliferation, epithelial-mesenchymal transition (EMT), cancer cell invasion and metastasis, etc. In glioma, the transcription factor ZEB2 can bind to the miR-637 promoter region and inhibit miR-637 expression. Besides, miR-637 could be negatively regulated by competing endogenous RNA (ceRNAs) comprising 13 circular RNA (circRNAs) and 9 long non-coding RNA (lncRNAs). miR-637 is involved in regulating five signaling pathways, including the Jak/STAT3, Wnt/β-catenin, PI3K/AKT, and ERK signaling pathways. Low miR-637 expression was significantly associated with larger tumors and later tumor node metastasis (TNM) staging in cancer patients. Low miR-637 expression was also associated with poorer overall survival (OS) in cancer patients such as glioblastoma and low-grade gliomas (GBM/LGG), non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), and ovarian cancer (OV). Low expression of miR-637 increases the resistance of colorectal cancer (CRC) and human cholangiocarcinoma (CHOL) cancer cells to three anticancer chemotherapeutics (gemcitabine (dFdC), cisplatin (DDP), and oxaliplatin (OXA)). Our work summarizes the abnormal expression of miR-637 in various cancers, expounds on the ceRNA regulatory network and signaling pathway involved in miR-637, and summarizes the effect of its abnormal expression on the biological behavior of tumor cells. At the same time, the relationship between the expression levels of miR-637 and its related molecules and the prognosis and pathological characteristics of patients was further summarized. Finally, our work points out the insufficiency of miR-637 in current studies and is expected to provide potential clues for future miR-637-related studies.

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“…Long non-coding RNA (lncRNA) is a non-coding RNA with a length of more than 200 nt that can regulate transcription, epigenetic modification, and translation [ 53 ]. CircRNAs, lncRNAs, and miRNAs constitute a ceRNA regulatory network to regulate downstream protein-coding gene expression [ 54 ]. As shown in Table 4 and Figure 4 , miR-944 can constitute 11 ceRNA regulatory axes, involving six circRNAs (CircFUT8, CircHAS2, CircCSPP1, CircSERPINA3, CircBACH2, and CircZFR) and five lncRNAs (JPX, SNHG6, LINC00899, PRNCR1, and FGD5-AS1).…”

Section: The Cerna Network Of Mir-944 In Cancermentioning

confidence: 99%

Novel Insights into miR-944 in Cancer

Shen

Wang

Liang

et al. 2022

Cancers

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miRNA is a class of endogenous short-chain non-coding RNAs consisting of about 22 nucleotides. miR-944 is located in the fourth intron of the TP63 gene in the 3q28 region. miR-944 is abnormally expressed in cancers in multiple systems including neural, endocrine, respiratory, reproductive, and digestive systems. miR-944 can target at least 27 protein-coding genes. miR-944 can regulate a series of cell behaviors, such as cell cycle, proliferation, invasion and migration, EMT, apoptosis, etc. miR-944 participates in the networks of 11 ceRNAs, including six circRNAs and five lncRNAs. miR-944 is involved in three signaling pathways. The abnormal expression of miR-944 is closely related to the clinicopathological conditions of various cancer patients. Deregulated expression of miR-944 is significantly associated with clinicopathology and prognosis in cancer patients. In addition, miR-944 is also associated with the development of DDP, RAPA, DOX, and PTX resistance in cancer cells. miR-944 is involved in the anticancer molecular mechanisms of matrine and Rhenium-liposome drugs. In conclusion, this work systematically summarizes the related findings of miR-944, which will provide potential hints for follow-up research on miR-944.

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miR-1908 Dysregulation in Human Cancers

Cited by 12 publications

References 77 publications

The tumor suppressor role and ceRNA network of miR-1294 in cancer

The tumor suppressor role and ceRNA network of miR-1294 in cancer

Dysfunction and ceRNA network of the tumor suppressor miR-637 in cancer development and prognosis

Novel Insights into miR-944 in Cancer

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