miR-154 inhibits prostate cancer cell proliferation by targeting CCND2

Zhu, Chen; Shao, Pengfei; Bao, Meiling; Li, Pu; Zhou, Hai; Cai, Hongzhou; Cao, Qiang; Liu, Tao; Meng, Xia; Ju, Xingrong; Qin, Chao; Li, Jie; Chen, Yin

doi:10.1016/j.urolonc.2012.11.013

Cited by 54 publications

(48 citation statements)

References 19 publications

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“…Xin et al (30) reported that miR-154 inhibited the proliferation, colony formation, migration and invasion of colorectal cancer cells. In prostate cancer, enforced miR-154 expression decreased the proliferation of prostate cancer cells in vitro (31). In accord with the present study, these studies suggest that miR-154 acts as a tumor suppressor and may be a suitable therapeutic target in these types of cancer.…”

Section: Discussionsupporting

confidence: 90%

MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells

et al. 2017

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Abstract. Breast cancer is the leading cause for cancer-associated mortality in women. Although great progress has been made in the earlier diagnosis and systemic therapy of patients with breast cancer in recent years, recurrence or distant metastasis continue to present major barriers to the successful treatment of breast cancer. Therefore, fully understanding the molecular mechanisms underlying the progression of breast cancer may be critical for the development of effective therapeutic strategies against breast cancer. The aim of the present study was to explore the expression, function and molecular mechanisms of microRNA-154 (miR-154) in human breast cancer. It was demonstrated that miR-154 was significantly downregulated in breast cancer tissue and cell lines. The restoration of miR-154 expression suppressed the proliferation, migration and invasion of breast cancer cells. ADAM metallopeptidase domain 9 (ADAM9) was identified as a novel direct target for miR-154 in breast cancer. It was demonstrated that miR-154 acted as a tumor suppressor in breast cancer by targeting ADAM9. The results of the present study suggest that the restoration of miR-154 expression may be an effective therapeutic strategy for the treatment of breast cancer in the future.

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Section: Discussionsupporting

confidence: 90%

MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells

et al. 2017

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“…miR-154, a recently identified miRNA, has been reported to act as a tumor suppressor in a variety of tumors by targeting several oncogenes (15,17,30,31). For example, Zhu et al (16,31) reported that miR-154 inhibited the growth of prostate cancer cells by targeting high-mobility group AT-hook 2 and cyclin D2 (CCND2).…”

Section: Discussionmentioning

confidence: 99%

“…For example, Zhu et al (16,31) reported that miR-154 inhibited the growth of prostate cancer cells by targeting high-mobility group AT-hook 2 and cyclin D2 (CCND2). Xin et al (18) reported that miR-154 remarkably suppressed cell proliferation, colony formation, migration and invasion in colorectal cancer cells by targeting Toll-like receptor 2.…”

Section: Discussionmentioning

confidence: 99%

miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2

et al. 2016

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Abstract. Emerging evidence suggests that microRNAs (miRs) play critical roles in the development and progression of non-small cell lung cancer (NSCLC). In a previous study, the present authors demonstrated that miR-154 acts as a tumor suppressor in NSCLC; however, its underlying molecular mechanism and target in NSCLC remain poorly understood. In the present study, ectopic expression of miR-154 remarkably suppressed cell migration and invasion in NSCLC cells.Zinc finger E-box binding homeobox 2 (ZEB2) was identified as a direct target of miR-154 in NSCLC cells. Furthermore, overexpression of miR-154 could decrease the expression of ZEB2 at the messenger RNA and protein levels. Ectopic expression of miR-154 also increased the levels of E-cadherin, an epithelial marker, and decreased the levels of vimentin, a mesenchymal marker, which contributed to suppress epithelial-mesenchymal transition (EMT) and to inhibit cell migration and invasion. In addition, downregulation of ZEB2 exerted similar effects to those caused by miR-154 overexpression on NSCLC cell migration and invasion, while upregulation of ZEB2 could significantly reverse the inhibitory effects on migration and invasion caused by miR-154 on NSCLC cells. These findings demonstrated that miR-154 inhibited migration and invasion of NSCLC cells by regulating EMT through targeting ZEB2, suggesting that miR-154 may be a potential anticancer therapeutic target for NSCLC.

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“…Furthermore, miR-154 was noted to serve an essential role in regulating the growth, colony formation, migration and invasion of colorectal cancer cells (25). In prostate cancer, ectopic miR-154 expression inhibited proliferation, migration and invasion (24,26). These findings indicated that miR-154 could be investigated as a therapeutic target for these human cancer types.…”

Section: Discussionmentioning

confidence: 97%

“…With regard to miR-154, several targets have been determined in previous studies, including Wnt5a in osteosarcoma (22), Zinc finger E-box-binding homeobox 2 in hepatocellular carcinoma (23), toll-like receptor 2 in colorectal cancer (25), and high-mobility group AT-hook 2 (24) and cyclin D2 (26) in prostate cancer. In the present study, a novel direct target gene of miR-154, BMI-1, was identified.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑154 functions as a tumor suppressor in non‑small cell lung cancer through directly targeting B‑cell‑specific Moloney murine leukemia virus insertion site 1

et al. 2018

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Abstract. Lung cancer remains the leading cause of cancer-associated mortality in China and worldwide. Increasing numbers of studies have demonstrated that microRNAs (miRNAs/miRs) have vital functions in numerous developmental processes and tumorigenesis. The aim of the present study was to investigate miR-154 expression in non-small cell lung cancer (NSCLC), and to explore the roles of miR-154 in the carcinogenesis and progression of this cancer. Reverse transcription-polymerase chain reaction (RT-qPCR) was performed to detect miR-154 expression in NSCLC tissues and cell lines. In addition, cell proliferation assay, migration and invasion assays were adopted to investigate the functional roles of miR-154 in NSCLC. Bioinformatics analysis, luciferase reporter assay, RT-qPCR and western blot analysis were used to explore the potential targets of miR-154 in NSCLC. According to the results, miR-154 was significantly downregulated in NSCLC tissues and cell lines. Restoration of miR-154 expression inhibited proliferation, migration and invasion of NSCLC cells. In addition, B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI-1) was identified as a direct target gene of miR-154 in NSCLC. In conclusion, miR-154 may function as a tumor suppressor in NSCLC, partly by regulating BMI-1, and the modulation of miR-154 expression represents a potential strategy for the treatment of NSCLC patients. IntroductionLung cancer, a highly malignant tumor, is the leading cause of cancer-associated mortality in males and females worldwide (1). The incidence and mortality rates of non-small cell lung cancer are increasing in developing countries, including China, due to the increase in the use of tobacco as well as air pollution (2). According to its pathological pattern, lung cancer may be divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) (3). NSCLC, which includes adenocarcinoma, squamous cell carcinoma, adenosquamous cell carcinoma and large cell carcinoma, accounts for ~80-85% of all lung cancer cases (4). Despite advances in traditional treatments, including surgery, supplemented with radiotherapy and chemotherapy, the prognosis remains poor and the five-year overall survival rate is extremely low (17.1%) (5). These facts indicate an urgent requirement to fully understand the molecular mechanisms underlying the carcinogenesis and progression of NSCLC, and to investigate novel therapeutic targets to control this malignant disease.Increasing studies have demonstrated that microRNAs (miRNAs/miRs) have vital functions in numerous developmental processes and tumorigenesis, including the progression of NSCLC (6-8). miRNAs represent a group of small (~19-25 nucleotides), non-protein-coding, and endogenous single RNAs, which negatively regulate gene expression by binding to the 3' untranslated regions (3'UTRs) of target genes in an imperfect base pairing manner, causing mRNA cleavage or translational repression (9,10). To date, miRNAs have been demonstrated to regulate >30% of all cellular pro...

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miR-154 inhibits prostate cancer cell proliferation by targeting CCND2

Cited by 54 publications

References 19 publications

MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells

MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells

miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2

MicroRNA‑154 functions as a tumor suppressor in non‑small cell lung cancer through directly targeting B‑cell‑specific Moloney murine leukemia virus insertion site 1

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