MiR-153 regulates metastases of gastric cancer through Snail

Wang, Zhongli; Liu, Chao

doi:10.1007/s13277-015-3846-8

Cited by 21 publications

(19 citation statements)

References 14 publications

(14 reference statements)

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“…By contrast, miR-153 inhibited the proliferation and invasion of human laryngeal squamous cell carcinoma cells by inhibiting the expression of kruppel-like factor 5 (21). miR-153 may inhibit cell migration and invasion of gastric cancer cells by directly targeting Snail (22). A tumor suppressor function of miR-153 was revealed in glioblastoma (23).…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA‑153 inhibits cell proliferation, migration, invasion and epithelial‑mesenchymal transition in breast cancer via direct targeting of RUNX2

Zuo

Liu

et al. 2019

Exp Ther Med

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A number of microRNAs (miRNAs) are involved in the development and malignant progression of numerous types of human cancer including breast cancer. The underlying regulatory mechanism of miRNA-153 (miR-153) in breast cancer progression remains largely unknown. The present study demonstrated that miR-153 expression levels were significantly reduced in breast cancer tissue samples and cell lines, compared with adjacent healthy tissue samples and normal human breast cell line MCF-10A. In addition, low miR-153 expression was associated with advanced clinical staging and metastasis in patients with breast cancer. However, no association with age, subtype or differentiation was identified. Furthermore, patients with breast cancer with low miR-153 expression had poor prognosis, compared with patients with breast cancer with high miR-153 expression. Overexpression of miR-153 reduced proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in breast cancer SK-BR-3 and BT-549 cells. Runt-related transcription factor 2 (RUNX2), which was revealed to be significantly upregulated in breast cancer, was verified as a target gene of miR-153 in SK-BR-3 and BT-549 cells by luciferase reporter gene assay. High RUNX2 expression was associated with advanced clinical staging as well as distant and lymph node metastasis in patients with breast cancer. However, no association with age, subtype or differentiation was identified. Additionally, an inverse correlation between miR-153 and RUNX2 mRNA expression levels was observed in breast cancer tissues. RUNX2 overexpression reduced the suppressive effects of miR-153 on the proliferation, migration, invasion and EMT of SK-BR-3 and BT-549 cells. The present study indicated that miR-153 may serve a role in breast tumor growth and metastasis via direct targeting of RUNX2. The miR-153/RUNX2 axis may be used as a potential therapeutic target in breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

“…In different types of human cancer, miR-153 appears to be involved in either promoting or suppressing tumor growth and progression (20)(21)(22). Wu et al (20) revealed that miR-153 promoted prostate cancer cell proliferation by targeting PTEN.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑153 inhibits cell proliferation, migration, invasion and epithelial‑mesenchymal transition in breast cancer via direct targeting of RUNX2

Zuo

Liu

et al. 2019

Exp Ther Med

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“…Furthermore, the downregulation of miR-153 accelerates epithelial-mesenchymal transition (EMT) via the regulation of the Snail family transcriptional repressor 1 (SNAI1) expression level ( 23 ). Clinical analysis indicated that the low expression level of miR-153 in patients with gastric cancer was associated with poor prognosis and tumor metastasis ( 24 ). In addition, a previous report indicated that miR-153 expression was decreased in lung cancer tissues compared with that in adjacent noncancerous tissues ( 24 ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑153 suppresses human laryngeal squamous cell carcinoma migration and invasion by targeting the SNAI1 gene

Zhang

2018

Oncol Lett

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Human laryngeal squamous cell carcinoma (LSCC) is a malignant cancer type. Epithelial-mesenchymal transition marker Snail family transcriptional repressor 1 (SNAI1) is associated with the occurrence, development, invasion and metastasis of numerous tumor types, such as lung, liver and ovarian cancer. Previous studies have indicated that microRNA-153 (miR-153) may serve as a novel tumor suppressor, which is involved in tumor metastasis; however, the role and clinical significance of miR-153 in LSCC are not fully understood. The aim of the present study was to determine the role of miR-153 in the growth and aggressiveness of LSCC cells. Bioinformatics prediction method, western blot analysis, Matrigel invasion assay and immunofluorescence were used to analyze whether SNAI1 can be regulated and controlled by miR-153 in LSCC cells. An inverse association between miR-153 and SNAI1 was observed in LSCC tissues. It was demonstrated that SNAI1 is a direct target of miR-153 in LSCC. In addition, the results indicated that miR-153 knockdown inhibited PCI-13 cell migration and invasion by targeting SNAI1, which may be a potential marker that can reflect the degree of malignancy in patients with LSCC. Furthermore, miR-153 knockdown decreased Twist family BHLH transcription factor 1 and metastasis-associated 1 family member 3 expression in LSCC cells. In conclusion, these data indicated that miR-153 regulates LSCC migration via the targeting of SNAI1 gene, which may be a potential predictor for patients with LSCC.

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“…Another example of miRNA that is described as a direct regulator of SNAIL expression in plenty tumor types is miR-153. The downregulation of SNAIL by miR-153 suppresses human laryngeal squamous cell carcinoma migration and invasion [75], melanoma cells proliferation and invasion [76], esophageal squamous cell carcinoma progression [77], and gastric cancer metastasis [78]; regulates EMT in hepatocellular carcinoma [79]; and diminishes pancreatic ductal adenocarcinoma migration and invasion with miR-153 serving as a prognostic marker [80].…”

Section: Micrornas Directly Targeting Snailmentioning

confidence: 99%

“…laryngeal squamous cell carcinoma [75] melanoma [76] esophageal squamous cell carcinoma [77] gastric cancer [78] hepatocellular carcinoma [79] pancreatic ductal adenocarcinoma [80] miR-182 breast cancer [88] miR-199a lung cancer [91] papillary thyroid carcinoma [93] miR-203 breast cancer [86] miR-204 gastric cancer [90] miR-211-5p renal cancer [98] miR-363 ovarian cancer [94] miR-410-3p breast cancer [87] miR-486-5p prostate cancer [97] miR-491-5p gastric cancer [89] miR-502-5p hepatocellular carcinoma [96] miR-940 lung cancer [92]…”

Section: Micrornas Directly Targeting Snailmentioning

confidence: 99%

Interplay among SNAIL Transcription Factor, MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Regulation of Tumor Growth and Metastasis

Skrzypek

Majka

2020

Cancers

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SNAIL (SNAI1) is a zinc finger transcription factor that binds to E-box sequences and regulates the expression of genes. It usually acts as a gene repressor, but it may also activate the expression of genes. SNAIL plays a key role in the regulation of epithelial to mesenchymal transition, which is the main mechanism responsible for the progression and metastasis of epithelial tumors. Nevertheless, it also regulates different processes that are responsible for tumor growth, such as the activity of cancer stem cells, the control of cell metabolism, and the regulation of differentiation. Different proteins and microRNAs may regulate the SNAIL level, and SNAIL may be an important regulator of microRNA expression as well. The interplay among SNAIL, microRNAs, long non-coding RNAs, and circular RNAs is a key event in the regulation of tumor growth and metastasis. This review for the first time discusses different types of regulation between SNAIL and non-coding RNAs with a focus on feedback loops and the role of competitive RNA. Understanding these mechanisms may help develop novel therapeutic strategies against cancer based on microRNAs.

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MiR-153 regulates metastases of gastric cancer through Snail

Cited by 21 publications

References 14 publications

MicroRNA‑153 inhibits cell proliferation, migration, invasion and epithelial‑mesenchymal transition in breast cancer via direct targeting of RUNX2

MicroRNA‑153 inhibits cell proliferation, migration, invasion and epithelial‑mesenchymal transition in breast cancer via direct targeting of RUNX2

MicroRNA‑153 suppresses human laryngeal squamous cell carcinoma migration and invasion by targeting the SNAI1 gene

Interplay among SNAIL Transcription Factor, MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Regulation of Tumor Growth and Metastasis

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