MiR-150-5p regulates the functions of type 2 innate lymphoid cells via the ICAM-1/p38 MAPK axis in allergic rhinitis

Zhang, Lifeng; Meng, Wei; Chen, Xiangjing; Ning, Yunhong; Sun, Meng; Ren-zhong, Wang

doi:10.1007/s11010-021-04346-4

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…As the expression of miR-17-3p is itself induced by TNF-α via NF-κB, the study provided an elegant demonstration of ICAM-1 post-transcriptional regulation by miRNA-mediated negative feedback. Additional studies have implicated numerous regulatory RNAs in the post-transcriptional regulation of ICAM-1 expression in various contexts, including miR-126-3p in the context of IL-6 stimulation [49]; miR-150-5p in acute respiratory distress syndrome [50] and allergic rhinitis [51], miR-223 in Kawasaki disease [52,53] and sepsis [54], miR148b-3p in coronary artery disease [55], and ICAM-1 related long non-coding RNA (ICR) in atherosclerosis [56], retinal vasculopathy [57], and hepatocellular carcinoma [58].…”

Section: Post-transcriptional Regulationmentioning

confidence: 99%

Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule

Haydinger

Ashander

Tan

et al. 2023

Biology

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Intercellular adhesion molecule 1 (ICAM-1) is a transmembrane protein in the immunoglobulin superfamily expressed on the surface of multiple cell populations and upregulated by inflammatory stimuli. It mediates cellular adhesive interactions by binding to the β2 integrins macrophage antigen 1 and leukocyte function-associated antigen 1, as well as other ligands. It has important roles in the immune system, including in leukocyte adhesion to the endothelium and transendothelial migration, and at the immunological synapse formed between lymphocytes and antigen-presenting cells. ICAM-1 has also been implicated in the pathophysiology of diverse diseases from cardiovascular diseases to autoimmune disorders, certain infections, and cancer. In this review, we summarize the current understanding of the structure and regulation of the ICAM1 gene and the ICAM-1 protein. We discuss the roles of ICAM-1 in the normal immune system and a selection of diseases to highlight the breadth and often double-edged nature of its functions. Finally, we discuss current therapeutics and opportunities for advancements.

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Section: Post-transcriptional Regulationmentioning

confidence: 99%

Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule

Haydinger

Ashander

Tan

et al. 2023

Biology

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“…VCAM-1-VLA-4-dependent leukocyte attraction is generally observed with monocytes and monocyte-like cell lines ( 56 ). Previous research has indicated that miR-150-5p regulates the function of lymphoid cells via the ICAM-1/p38/MAPK signaling pathway in allergic rhinitis ( 57 ). Until now, no studies have examined whether miR-150-5p regulates CAM-dependent leukocyte adherence in OASFs.…”

Section: Discussionmentioning

confidence: 99%

miR-150-5p and XIST interaction controls monocyte adherence: Implications for osteoarthritis therapy

et al. 2022

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Recent literature highlights the importance of microRNAs (miRNAs) functioning as diagnostic biomarkers and therapeutic agents in osteoarthritis (OA) and regulators of gene expression. In OA pathogenesis, cell adhesion molecules (CAMs), especially vascular cell adhesion protein 1 (VCAM-1), recruit monocyte infiltration to inflamed synovial tissues and thus accelerate OA progression. Up until now, little has been known about the regulatory mechanisms between miRNAs, long non-coding RNAs (lncRNAs) and VCAM-1 during OA progression. The evidence in this article emphasizes that the functional feature of miR-150-5p is an interaction with the lncRNA X-inactive specific transcript (XIST), which regulates VCAM-1-dependent monocyte adherence in OA synovial fibroblasts (OASFs). Levels of VCAM-1, CD11b (a monocyte marker) and XIST expression were higher in human synovial tissue samples and OASFs, while levels of miR-150-5p were lower in human OA synovial tissue compared with non-OA specimens. XIST enhanced VCAM-1-dependent monocyte adherence to OASFs. Upregulation of miR-150-5p inhibited the effects of XIST upon monocyte adherence. Administration of miR-150-5p effectively ameliorated OA severity in anterior cruciate ligament transection (ACLT) rats. The interaction of miR-150-5p and XIST regulated VCAM-1-dependent monocyte adherence and attenuated OA progression. Our findings suggest that miR-150-5p is a promising small-molecule therapeutic strategy for OA.

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“…Their miRNA profiling shows that miR103a-3p is markedly up-regulated and enhances IL-5 production by ILC2s after coculture with human ILC2s [61] through methylation of GATA3 arginine residues. While ICAM-1 appears to be essential for ILC2 development and function, it has been found in AR patients and animal models that overexpression of miR-150-5p can decrease ICAM-1 expression, whereas a decrease in ICAM-1 can led to a downregulation of GATA3 levels, which can, in turn, inhibit the function of ILC2s from alleviating allergic symptoms [62]. The results of an in vivo study in a mouse model of AR showed that miR-375 enhanced the function of ILC2s by regulating TSLP [63], providing a potential therapeutic target for AR.…”

Section: Other Ilc2smentioning

confidence: 99%

The Relationship between microRNAs, ILC2s and Th2 Cells

Li¹,

Wang²,

Zhao³

et al. 2023

New Perspectives on Asthma

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Asthma is a common and chronic inflammatory disease. The pathogenic mechanism underlying asthma is complex. Many inflammatory cells have been recognized as involved in asthma, containing lymphocytes (T, B cells), ILC2s, eosinophils, and other types of immune and inflammatory cells. It is well-established that allergen-specific Th2 cells play a central role in developing allergic asthma. In addition, in recent years, increasing studies have found that ILC2s can contribute to the pathogenesis of asthma by promoting the immune response of Th2 and secreting Th2 cytokines. MicroRNAs (MiRNAs and MiRs) is involved in immune inflammation and can induce excessive secretion of Th2 cytokines. The regulation of miRNAs to their targeting genes plays an important role in the development of asthma. This chapter has discussed altered expression and functions of miRNAs in Th2 and ILC2s in asthma, in order to better understand the mechanics of pathogenesis of asthma, and provide potential miRNA diagnostic indicators and therapeutic targets.

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MiR-150-5p regulates the functions of type 2 innate lymphoid cells via the ICAM-1/p38 MAPK axis in allergic rhinitis

Cited by 9 publications

References 43 publications

Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule

Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule

miR-150-5p and XIST interaction controls monocyte adherence: Implications for osteoarthritis therapy

The Relationship between microRNAs, ILC2s and Th2 Cells

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