miR-146b level and variants is associated with endometriosis related macrophages phenotype and plays a pivotal role in the endometriotic pain symptom

Zhang, Zengzhen; Li, Huiqing; Zhao, Zirun; Gao, Baofeng; Li, Meng; Feng, Xianguang

doi:10.1016/j.tjog.2018.12.003

Cited by 24 publications

(17 citation statements)

References 31 publications

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“…Zhang et al have shown association between the CT/CC genotypes of miR-146b rs1536309 and the risk of pain symptom of endometriosis. Moreover, they detected lower levels of the miR-146b and higher pro-inflammatory functions in macrophages from CT/CC genotype carriers (12). Nimi-Hoveidi et al have genotyped miR-143 rs41291957 and rs4705342 SNPs in infertile women with endometriosis and matched healthy subjects.…”

Section: Mirnas and Endometriosismentioning

confidence: 99%

“…rs1536309 CT/CC frequency is involved in increased pain susceptibility. miR-146b rs1536309 C > T polymorphism by regulating miR-146b expression was associated with the M1 polarization of macrophages (12) Infertile women (n = 77) with endometriosis and healthy controls (n = 226)…”

Section: Mirnas and Endometriosismentioning

confidence: 99%

“…They reported up-regulation of miR-146b peritoneal fluid supernatant and CD14 + monocytes/Macrophages of peritoneal fluid in endometriosis patients. This miRNA could inhibit the M1 polarization of endometrial stromal cells co-cultured macrophages ( 12 ). Table 1 shows the list of up-regulated miRNAs in samples obtained from patients with endometriosis.…”

Section: Mirnas and Endometriosismentioning

confidence: 99%

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Role of Non-coding RNAs in the Pathogenesis of Endometriosis

2020

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Endometriosis is a disorder characterized by the presence of endometrial glands and stroma like lesions outside of the uterus. Although several hypothesis have tried to explain the underlying cause of endometriosis, yet the main cause remained obscure. Recent studies have shown contribution of non-coding RNAs in the pathogenesis of endometriosis. Two classes of these transcripts namely long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have mostly attracted attention of researchers. Several studies have reported aberrant expression of these transcripts in affected tissues from patients as well as animal models. Modulation of important signaling pathways such as PI3K/AKT, P38-MAPK, ERK1/2-MAPK and Wnt-β catenin by miRNAs and lncRNAs have potentiated these molecules as biomarkers or therapeutic agents in endometriosis. Single nucleotide polymorphisms with miR-126, miR-143 and miR-146b have been associated with risk of endometriosis. Moreover, miRNAs and lncRNAs control inflammatory responses, cell proliferation, angiogenesis and tissue remodeling, thus understanding the role of these transcripts in endometriosis is a possible way to develop novel diagnostic tests and therapeutic targets for this disorder.

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Section: Mirnas and Endometriosismentioning

confidence: 99%

Section: Mirnas and Endometriosismentioning

confidence: 99%

Section: Mirnas and Endometriosismentioning

confidence: 99%

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Role of Non-coding RNAs in the Pathogenesis of Endometriosis

2020

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“…Importantly, the levels of secreted inflammatory cytokines of macrophages has been found to correlate with changes in miR-125b-5p and let-7b-5p in the serum of patients with endometriosis [89]. Other miR-146 targets, such as IRAK1, TRAF6, STAT1 and IRF5, play a key role in mediating M1 polarization; hence their regulation in endometrial tissue may be important in the etiopathogenesis of endometriosis [87].…”

Section: Role Of Mirnas In the Pathophysiology Of Endometriosismentioning

confidence: 99%

“…In addition, elevated levels of CD14 + monocytes/macrophages and miRNAs have been reported in peritoneal fluid supernatant from endometriosis patients. For example, miR-146b can inhibit M1 polarization of endometrial stromal cells co-cultured with macrophages [87], which are reported to be the main source of pro-inflammatory chemotactic cytokines and the main source of neuroangiogenesis [88]. The evolution of endometriosis has been linked to a range of M1 macrophage polarization markers, including tumor necrosis factor α (TNF-α)-a marker with a strong inflammatory, cytotoxic and angiogenic potential, and IL-1β, IL-12, IL-8, IL-10 and IL-6, which promote the growth of endometrial cells.…”

Section: Role Of Mirnas In the Pathophysiology Of Endometriosismentioning

confidence: 99%

Circulating miRNAs Related to Epithelial–Mesenchymal Transitions (EMT) as the New Molecular Markers in Endometriosis

Zubrzycka

Migdalska-Sęk

Jędrzejczyk³

et al. 2021

CIMB

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Endometriosis is a chronic gynecological disease defined by the presence of endometrial-like tissue found outside the uterus, most commonly in the peritoneal cavity. Endometriosis lesions are heterogenous but usually contain endometrial stromal cells and epithelial glands, immune cell infiltrates and are vascularized and innervated by nerves. The complex etiopathogenesis and heterogenity of the clinical symptoms, as well as the lack of a specific non-invasive diagnostic biomarkers, underline the need for more advanced diagnostic tools. Unfortunately, the contribution of environmental, hormonal and immunological factors in the disease etiology is insufficient, and the contribution of genetic/epigenetic factors is still fragmentary. Therefore, there is a need for more focused study on the molecular mechanisms of endometriosis and non-invasive diagnostic monitoring systems. MicroRNAs (miRNAs) demonstrate high stability and tissue specificity and play a significant role in modulating a range of molecular pathways, and hence may be suitable diagnostic biomarkers for the origin and development of endometriosis. Of these, the most frequently studied are those related to endometriosis, including those involved in epithelial–mesenchymal transition (EMT), whose expression is altered in plasma or endometriotic lesion biopsies; however, the results are ambiguous. Specific miRNAs expressed in endometriosis may serve as diagnostics markers with prognostic value, and they have been proposed as molecular targets for treatment. The aim of this review is to present selected miRNAs associated with EMT known to have experimentally confirmed significance, and discuss their utility as biomarkers in endometriosis.

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microRNAs in female infertility: An overview

Bahmyari

Jamali

Khatami

et al. 2021

Cell Biochemistry & Function

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Infertility impacts a considerable number of women worldwide, and it affects different aspects of family life and society. Although female infertility is known as a multifactorial disorder, there are strong genetic and epigenetic bases. Studies revealed that miRNAs play critical roles in initiation and development of female infertility related disorders. Early diagnosis and control of these diseases is an essential key for improving disease prognosis and reducing the possibility of infertility and other side effects. Investigating the possible use of miRNAs as biomarkers and therapeutic options is valuable, and it merits attention. Thus, in this article, we reviewed research associated with female diseases and highlighted microRNAs that are related to the polycystic ovary syndrome (up to 30 miRNAs), premature ovarian failure (10 miRNAs), endometriosis (up to 15 miRNAs), uterine fibroids (up to 15 miRNAs), endometrial polyp (3 miRNAs), and pelvic inflammatory (6 miRNAs), which are involved in one or more ovarian or uterine disease‐causing processes.

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miR-146b level and variants is associated with endometriosis related macrophages phenotype and plays a pivotal role in the endometriotic pain symptom

Cited by 24 publications

References 31 publications

Role of Non-coding RNAs in the Pathogenesis of Endometriosis

Role of Non-coding RNAs in the Pathogenesis of Endometriosis

Circulating miRNAs Related to Epithelial–Mesenchymal Transitions (EMT) as the New Molecular Markers in Endometriosis

microRNAs in female infertility: An overview

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