<scp>microRNAs</scp> in female infertility: An overview

Bahmyari, Sedigheh; Jamali, Zeinab; Khatami, Seyyed Hossein; Vakili, Omid; Roozitalab, Mahin; Savardashtaki, Amir; Solati, Arezoo; Mousavi, Pegah; Shabaninejad, Zahra; Vakili, Sina; Behrouj, Hamid; Ghasemi, Hassan

doi:10.1002/cbf.3671

Cited by 17 publications

(8 citation statements)

References 142 publications

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“…MiRNAs are small single-stranded RNA molecules (20–24 nucleotides) primarily contributing to post-transcriptional gene modulation through binding to the target gene’s 3′-untranslated region (3′UTR) to suppress the translation ( Ruan and Ouyang, 2009 ; Sana et al, 2012 ; Bahmyari et al, 2021 ; Mafi et al, 2022 ). Subcellular localization of miRNAs, the affinity of miRNA-related interconnections, and the number of target mRNAs and miRNAs influence the miRNA–target gene interactions ( O'Brien et al, 2018 ).…”

Section: Non-coding Rnas: a Summary Of Their Structure And Subclassif...mentioning

confidence: 99%

The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms

et al. 2023

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Breast cancer (BC) is the most common malignancy among women worldwide. Like many other cancers, BC therapy is challenging and sometimes frustrating. In spite of the various therapeutic modalities applied to treat the cancer, drug resistance, also known as, chemoresistance, is very common in almost all BCs. Undesirably, a breast tumor might be resistant to different curative approaches (e.g., chemo- and immunotherapy) at the same period of time. Exosomes, as double membrane-bound extracellular vesicles 1) secreted from different cell species, can considerably transfer cell products and components through the bloodstream. In this context, non-coding RNAs (ncRNAs), including miRNAs, long ncRNAs (lncRNAs), and circular RNAs (circRNAs), are a chief group of exosomal constituents with amazing abilities to regulate the underlying pathogenic mechanisms of BC, such as cell proliferation, angiogenesis, invasion, metastasis, migration, and particularly drug resistance. Thereby, exosomal ncRNAs can be considered potential mediators of BC progression and drug resistance. Moreover, as the corresponding exosomal ncRNAs circulate in the bloodstream and are found in different body fluids, they can serve as foremost prognostic/diagnostic biomarkers. The current study aims to comprehensively review the most recent findings on BC-related molecular mechanisms and signaling pathways affected by exosomal miRNAs, lncRNAs, and circRNAs, with a focus on drug resistance. Also, the potential of the same exosomal ncRNAs in the diagnosis and prognosis of BC will be discussed in detail.

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Section: Non-coding Rnas: a Summary Of Their Structure And Subclassif...mentioning

confidence: 99%

The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms

et al. 2023

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“…In addition to their roles in fertilization and early embryonic development, miRNAs have also been implicated in various reproductive disorders, including infertility, endometriosis, and polycystic ovary syndrome (PCOS) (Abdalla et al, 2020). miR-122 has been shown to be down-regulated in the sperm of infertile men, and miR-21 has been shown to be up-regulated in the endometrium with endometriosis (Bahmyari et al, 2021). Understanding the role of miRNAs in fertilization may provide new insights into the causes of infertility and other reproductive disorders.…”

Section: Mirna In Fertilizationmentioning

confidence: 99%

Role of MicroRNAs in Mammalian Reproduction

Shavi,

Saini,

Gupta

et al. 2023

Anim. Reprod. Update

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MicroRNAs are small, endogenous, non-coding RNA molecules that are around 19-25 nucleotides long. Most miRNAs are produced via transcription of DNA sequences into primary miRNAs, precursor miRNAs, and then mature miRNAs. These miRNA molecules base-pair to mRNAs to control gene expression post-transcriptionally. Mammalian genome now has over 2000 annotated miRNAs which are thought to influence one-third of the genes in the genome since each miRNA can regulate hundreds of target genes. miRNAs are involved in morphogenesis, tissue maintenance, cell development, differentiation, apoptosis, and metabolism etc. This review aims to summarize the current understanding of the role of miRNAs in various stages of mammalian reproductive biology and their involvement in reproductive disorders. We have also summarized the recent advances about miRNA and provide an updated overview of the literature, including the most recent and relevant studies.

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“…miRNAs miRNAs are endogenous small single-stranded ncRNAs that are about 17-25 nucleotides long, involved in gene modulation, as well as epigenetic modifications. Given their prominent roles in many biological events, the potential of miRNAs as novel diagnostic, prognostic, and therapeutic targets has been constantly studied [25][26][27]. More than 50% of the genes responsible for the biogenesis of miRNAs are located at fragile chromosomal sites or cancer-associated genomic regions, suggesting key roles for miRNAs in the development of human malignancies [28].…”

Section: Humanmentioning

confidence: 99%

Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment

et al. 2022

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Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors have poor 5-year survival for patients. Gliomas are principally characterized by rapid diffusion as well as high levels of cellular heterogeneity. However, to date, the exact pathogenic mechanisms, contributing to gliomas remain ambiguous. MicroRNAs (miRNAs), as small noncoding RNAs of about 20 nucleotides in length, are known as chief modulators of different biological processes at both transcriptional and posttranscriptional levels. More recently, it has been revealed that these noncoding RNA molecules have essential roles in tumorigenesis and progression of multiple cancers, including gliomas. Interestingly, miRNAs are able to modulate diverse cancer-related processes such as cell proliferation and apoptosis, invasion and migration, differentiation and stemness, angiogenesis, and drug resistance; thus, impaired miRNAs may result in deterioration of gliomas. Additionally, miRNAs can be secreted into cerebrospinal fluid (CSF), as well as the bloodstream, and transported between normal and tumor cells freely or by exosomes, converting them into potential diagnostic and/or prognostic biomarkers for gliomas. They would also be great therapeutic agents, especially if they could cross the blood–brain barrier (BBB). Accordingly, in the current review, the contribution of miRNAs to glioma pathogenesis is first discussed, then their glioma-related diagnostic/prognostic and therapeutic potential is highlighted briefly.

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microRNAs in female infertility: An overview

Cited by 17 publications

References 142 publications

The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms

The landscape of exosomal non-coding RNAs in breast cancer drug resistance, focusing on underlying molecular mechanisms

Role of MicroRNAs in Mammalian Reproduction

Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment

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