miR-142-3p as a novel biomarker for predicting poor prognosis in renal cell carcinoma patients after surgery

Peng, Xiqi; Pan, Xiang; Liu, Kaihao; Zhang, Chunduo; Zhao, Liwen; Li, Hang; Guan, Xin; Xu, Weijie; Xu, Jinling; Zhang, Fangting; Lai, Yongqing

doi:10.1177/1724600819866456

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…In RCC, a number of miRNAs have identified associated with the prognosis of patients and functioned as prognostic biomarkers,23 such as miR-30a24 and miR-660-5p 25. A recent study demonstrated that the upregulation of miR-142-3p is correlated with poor prognosis of RCC patients and may be a prognostic biomarker 26. Therefore, investigation of cancer-associated miRNAs that are crucial for the progression of RCC may provide more therapeutic targets and prognosis improvement for RCC patients.…”

Section: Discussionmentioning

confidence: 99%

<p>Aberrant Expression of miR-592 Is Associated with Prognosis and Progression of Renal Cell Carcinoma</p>

Lv¹,

Shen²,

et al. 2019

OTT

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PurposeMicroRNAs have recently reported playing a vital role in the development of cancers. However, the role of miR-592 in renal cell carcinoma (RCC) has not been explored. In this study, the potential role of miR-592 was investigated in RCC.Patients and methodsThe expression of miR-592 was evaluated in RCC tissues and cell lines using qRT-PCR assays. The Kaplan-Meier analysis and Cox proportional hazards model analysis was used to analyze the prognostic value of miR-592 in RCC. The effects of miR-592 on cell proliferation, migration, and invasion were determined by cell counting kit-8 (CCK-8) and Transwell assays in vitro.ResultsThe results showed that miR-592 was significantly increased both in RCC tissues and cell lines. Overexpression of miR-592 was significantly associated with lymph node metastasis, TNM stage, and poor overall survival. And functional studies in two RCC cell lines (786-O and Caki-1) have shown that overexpression of miR-592 promoted cell proliferation, migration, and invasion, while silence of miR-592 inhibited cell proliferation, migration, and invasion. SPRY2 was a direct target of miR-592.ConclusionOverall, overexpression of miR-592 may be a prognostic biomarker and therapeutic strategy for patients with RCC, which is correlated with the progression of RCC.

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Section: Discussionmentioning

confidence: 99%

<p>Aberrant Expression of miR-592 Is Associated with Prognosis and Progression of Renal Cell Carcinoma</p>

Lv¹,

Shen²,

et al. 2019

OTT

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show abstract

“…Chen et al reported that miR-30a-3p could inhibit the invasion of RCC and serve as a new prognostic marker (21). miR-142-3p has also proved to be involved with tumorigenesis and the development of RCC (22). In addition to miRNAs, mRNAs including HHLA2 and syntaxin 6 were associated with decreased survival, and corresponding inhibitors held promise as a novel therapy against RCC (23,24).…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic and Immunotherapeutic Value of CD248 in Renal Cell Carcinoma

Zhang

et al. 2021

Front. Oncol.

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Background: Renal cell carcinoma (RCC) is the most common malignancy in the urinary system. Despite substantial improvements in available treatment options, the survival outcome of advanced RCC is unsatisfactory. Identifying novel biomarkers to assist in early diagnosis and to screen patients who are sensitive to immunotherapy would be beneficial. CD248 is a promising candidate that deserves to be investigated.Methods: The Cancer Genome Atlas (TCGA) data set and clinical specimens were adopted to analyze the expression of CD248 between normal and tumor tissues. Univariate and multivariate Cox regression analyses were employed to identify independent prognostic factors and construct a CD248-based prognostic signature. The correlation among the present signature, tumor-infiltrating immune cells (TIICs), the tumor mutation burden (TMB), and immunomodulatory molecules was evaluated. The weighted gene co-expression network analysis (WGCNA), the enrichment analysis, and the miRNA correlation analysis were performed to explore the underlying mechanism of CD248 in the progression of RCC.Results: The overexpression of CD248 in RCC was related to a poor prognosis, and a CD248-based prognostic signature could precisely stratify patients with RCC with different survival outcomes regardless of the training or testing cohort. The present signature could reflect the immunosuppressive landscape of RCC (i.e., increased infiltration of regulatory T cells and upregulated immune checkpoints), accompanied by deteriorated clinicopathologic indexes. The TMB and immunostimulatory molecules expression also increased with the risk score generated from the present signature. CD248 co-expressed gene sets were identified through the WGCNA algorithm, and several immunosuppressive Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were significantly enriched. The result of CD248-correlated miRNA further emphasized the importance of CD248 in RCC.Conclusion: CD248 is a valuable biomarker to improve the diagnostic and therapeutic efficiency of RCC. The immunosuppressive effect of CD248 co-expressed genes may provide insight for the present study, and miRNA would help to reveal the mechanism of the expressive regulation of CD248.

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“…miR-1181 was considered to be able to predict the prognosis of NSCLC, as its upregulation was associated with a poorer survival rate of patients with NSCLC. Accumulating evidence has demonstrated the prognostic value of miRNAs in several cancer types (26)(27)(28), and a variety of miRNAs, such as miR-519a, miR-378 and miR-1246, have been considered as prognostic biomarkers for NSCLC (29)(30)(31). In the present study, the results of the Cox regression analysis indicated that miR-1181 and the TNM stage were independent prognostic indicators for NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression

Liu

Wang

et al. 2021

Exp Ther Med

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Non-small cell lung cancer (NSCLC) is one of the most important causes of cancer-related death. miR-1181 has been reported to have roles in various cancer types and its function in the progression of NSCLC was investigated in the present study. A total of 118 patients with NSCLC were recruited and their tumor tissues were collected. The expression of miR-1181 in NSCLC tissues and cells was detected by reverse transcription-quantitative PCR. The prognostic value of miR-1181 was evaluated by Kaplan-Meier and Cox regression analysis and the roles of miR-1181 in cell proliferation, migration and invasion of NSCLC were analyzed by Cell Counting Kit-8 and Transwell assays. miR-1181 was indicated to be upregulated in NSCLC tissues and cell lines, and to be associated with lymph node metastasis and the TNM stage of patients. Patients with high miR-1181 expression had a poorer prognosis than those with low miR-1181 expression. miR-1181 levels and TNM stage were determined to be two independent prognostic factors for NSCLC. In addition, overexpression of miR-1181 exerted enhancing effects on cell proliferation, migration and invasion of NSCLC, while its knockdown inhibited these cellular processes. In conclusion, upregulation of miR-1181 in NSCLC was associated with lymph node metastasis and TNM stage of patients and was indicative of poor prognosis. miR-1181 was indicated to exert promoting effects on cell proliferation, migration and invasion of NSCLC cells and to be involved in tumor progression, providing novel insight for the development of biomarkers and therapies for NSCLC.

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miR-142-3p as a novel biomarker for predicting poor prognosis in renal cell carcinoma patients after surgery

Cited by 13 publications

References 33 publications

<p>Aberrant Expression of miR-592 Is Associated with Prognosis and Progression of Renal Cell Carcinoma</p>

<p>Aberrant Expression of miR-592 Is Associated with Prognosis and Progression of Renal Cell Carcinoma</p>

The Diagnostic and Immunotherapeutic Value of CD248 in Renal Cell Carcinoma

Prognostic value of miR‑1181 in non‑small cell lung cancer and its regulatory effect on tumor progression

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